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If a protein meets these conditions... i

Common conditions

... then these annotations are applied i

Protein namei

  • Recommended name:
    Cellular tumor antigen p53

Subunit structurei

  • Binds DNA as a homotetramer.

Subcellular locationi

Functioni

  • Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Cofactori

  • Zn2+Note: Binds 1 zinc ion per subunit.

Keywordsi