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Protein
Submitted name:

Hypermethylated in cancer 1 protein

Gene

Hic1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-3232118 SUMOylation of transcription factors

Names & Taxonomyi

Protein namesi
Submitted name:
Hypermethylated in cancer 1 proteinImported
Gene namesi
Name:Hic1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1338010 Hic1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiZ4YJP0

PTM databases

iPTMnetiZ4YJP0

Expressioni

Gene expression databases

BgeeiENSMUSG00000043099

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliZ4YJP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 270BTBInterPro annotationAdd BLAST64
Domaini597 – 624C2H2-typeInterPro annotationAdd BLAST28
Domaini667 – 694C2H2-typeInterPro annotationAdd BLAST28
Domaini695 – 722C2H2-typeInterPro annotationAdd BLAST28
Domaini723 – 750C2H2-typeInterPro annotationAdd BLAST28
Domaini751 – 774C2H2-typeInterPro annotationAdd BLAST24

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00880000138005
OMAiVIQACYS
OrthoDBiEOG091G051O
PhylomeDBiZ4YJP0

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR028424 HIC1
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44802 PTHR44802, 1 hit
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

Z4YJP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITRMRHHPW LKSSSFEDRT FPSPPPNWRD ITYKYVLGST QHKTPRFMGL
60 70 80 90 100
PGPISESPGG HIWKRANLQD LLSSASASLL AQVCARGRSP AAHSPRVAAR
110 120 130 140 150
WRHGRGSVCR FGPLQIRVCG KRGGAETRPG RGEDGPARQT DRGPGGRRAA
160 170 180 190 200
HCSHVPPWIR RQPGPGLPTC PPGECAGQTM LDTMEAPGHS RQLLLQLNNQ
210 220 230 240 250
RTKGFLCDVI IVVQNALFRA HKNVLAASSA YLKSLVVHDN LLNLDHDMVS
260 270 280 290 300
PAVFRLVLDF IYTGRLTDSV EAAAAAAVAP GAEPSLGAVL AAASYLQIPD
310 320 330 340 350
LVALCKKRLK RHGKYCHLRG GGSGGGGYAP YGRPGRGLRA ATPVIQACYS
360 370 380 390 400
SPAGPPPPPA AEPPSGPDAA VNTHCAELYA SGPGPAASLC APERRCSPLC
410 420 430 440 450
GLDLSKKSPP GSSVPERPLS ERELPPRPDS PPGAGPAVYK EPSLALPPLP
460 470 480 490 500
PLPFQKLEEA VPTPDPFRGS GGSPGPEPPG RPDGSSLLYR WMKHEPGLGS
510 520 530 540 550
YGDELVRDRG SPGERLEERG GDPAASPGGP PLGLVPPPRY PGSLDGPGTG
560 570 580 590 600
ADGDDYKSSS EETGSSEDPS PPGGHLEGYP CPHLAYGEPE SFGDNLYVCI
610 620 630 640 650
PCGKGFPSSE QLNAHVEAHV EEEEALYGRA EAAEVAAGAA GLGPPFGGGG
660 670 680 690 700
DKVTGAPGGL GELLRPYRCA SCDKSYKDPA TLRQHEKTHW LTRPYPCTIC
710 720 730 740 750
GKKFTQRGTM TRHMRSHLGL KPFACDACGM RFTRQYRLTE HMRIHSGEKP
760 770 780 790 800
YECQVCGGKF AQQRNLISHM KMHAVGGAAG AAGALAGLGG LPGVPGPDGK
810 820 830 840 850
GKLDFPEGVF AVARLTAEQL SLKQQDKAAA AELLAQTTHF LHDPKVALES
860 870 880 890
LYPLAKFTAE LGLSPDKAAE VLSQGAHLAA GPDSRTIDRF SPT
Length:893
Mass (Da):94,378
Last modified:June 11, 2014 - v1
Checksum:i311DD32D5A1E5DF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL603905 Genomic DNA No translation available.
RefSeqiNP_034560.2, NM_010430.2
UniGeneiMm.57250

Genome annotation databases

EnsembliENSMUST00000055619; ENSMUSP00000053483; ENSMUSG00000043099
GeneIDi15248
UCSCiuc007kdd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiZ4YJP0_MOUSE
AccessioniPrimary (citable) accession number: Z4YJP0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: May 23, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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