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Protein
Submitted name:

ELKS/Rab6-interacting/CAST family member 1

Gene

ERC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
ELKS/Rab6-interacting/CAST family member 1Imported
Gene namesi
Name:ERC1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:17072. ERC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiX6RM00.
PaxDbiX6RM00.

Expressioni

Gene expression databases

ExpressionAtlasiX6RM00. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354158.

Structurei

3D structure databases

ProteinModelPortaliX6RM00.
SMRiX6RM00. Positions 144-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili151 – 17828Sequence analysisAdd
BLAST
Coiled coili215 – 24935Sequence analysisAdd
BLAST
Coiled coili336 – 36631Sequence analysisAdd
BLAST
Coiled coili384 – 41835Sequence analysisAdd
BLAST
Coiled coili426 – 49570Sequence analysisAdd
BLAST
Coiled coili503 – 55149Sequence analysisAdd
BLAST
Coiled coili559 – 60749Sequence analysisAdd
BLAST
Coiled coili615 – 67460Sequence analysisAdd
BLAST
Coiled coili696 – 72328Sequence analysisAdd
BLAST
Coiled coili730 – 78859Sequence analysisAdd
BLAST
Coiled coili808 – 88982Sequence analysisAdd
BLAST
Coiled coili904 – 94542Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4809. Eukaryota.
ENOG410Y4GU. LUCA.
GeneTreeiENSGT00650000093320.

Family and domain databases

InterProiIPR019323. ELKS/CAST.
[Graphical view]
PANTHERiPTHR18861. PTHR18861. 2 hits.
PfamiPF10174. Cast. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

X6RM00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGSSVGGGS
60 70 80 90 100
GKTLSMENIQ SLNAAYATSG PMYLSDHENV GSETPKSTMT LGRSGGRLPY
110 120 130 140 150
GVRMTAMGSS PNIASSGVAS DTIAFGEHHL PPVSMASTVP HSLRQARDNT
160 170 180 190 200
IMDLQTQLKE VLRENDLLRK DVEVKESKLS SSMNSIKTFW SPELKKERAL
210 220 230 240 250
RKDEASKITI WKEQYRVVQE ENQHMQMTIQ ALQDELRIQR DLNQLFQQDS
260 270 280 290 300
SSRTGEPCVA ELTEENFQRL HAEHERQAKE LFLLRKTLEE MELRIETQKQ
310 320 330 340 350
TLNARDESIK KLLEMLQSKG LSAKATEEDH ERTRRLAEAE MHVHHLESLL
360 370 380 390 400
EQKEKENSML REEMHRRFEN APDSAKTKAL QTVIEMKDSK ISSMERGLRD
410 420 430 440 450
LEEEIQMLKS NGALSTEERE EEMKQMEVYR SHSKFMKNKV EQLKEELSSK
460 470 480 490 500
EAQWEELKKK AAGLQAEIGQ VKQELSRKDT ELLALQTKLE TLTNQFSDSK
510 520 530 540 550
QHIEVLKESL TAKEQRAAIL QTEVDALRLR LEEKETMLNK KTKQIQDMAE
560 570 580 590 600
EKGTQAGEIH DLKDMLDVKE RKVNVLQKKI ENLQEQLRDK EKQMSSLKER
610 620 630 640 650
VKSLQADTTN TDTALTTLEE ALAEKERTIE RLKEQRDRDE REKQEEIDNY
660 670 680 690 700
KKDLKDLKEK VSLLQGDLSE KEASLLDLKE HASSLASSGL KKDSRLKTLE
710 720 730 740 750
IALEQKKEEC LKMESQLKKA HEAALEARAS PEMSDRIQHL EREITRYKDE
760 770 780 790 800
SSKAQAEVDR LLEILKEVEN EKNDKDKKIA ELESLTSRQV KDQNKKVANL
810 820 830 840 850
KHKEQVEKKK SAQMLEEARR REDNLNDSSQ QLQVEELLMA MEKVKQELES
860 870 880 890 900
MKAKLSSTQQ SLAEKETHLT NLRAERRKHL EEVLEMKQEA LLAAISEKDA
910 920 930 940 950
NIALLELSSS KKKTQEEVAA LKREKDRLVQ QLKQQTQNRM KLMADNYEDD
960 970
HFKSSHSNQT NHKPSPDQDE EEGIWA
Length:976
Mass (Da):111,975
Last modified:June 11, 2014 - v1
Checksum:iEE926DACD351A86E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004671 Genomic DNA. No translation available.
AC004672 Genomic DNA. No translation available.
AC004802 Genomic DNA. No translation available.
AC004803 Genomic DNA. No translation available.
AC004804 Genomic DNA. No translation available.
AC006561 Genomic DNA. No translation available.
AC092469 Genomic DNA. No translation available.
AC234852 Genomic DNA. No translation available.
KC877502 Genomic DNA. No translation available.
KF455581 Genomic DNA. No translation available.
RefSeqiXP_011519246.1. XM_011520944.1.
UniGeneiHs.601216.

Genome annotation databases

EnsembliENST00000542302; ENSP00000445336; ENSG00000082805.
ENST00000634904; ENSP00000489414; ENSG00000283017.
GeneIDi23085.
UCSCiuc058jrb.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004671 Genomic DNA. No translation available.
AC004672 Genomic DNA. No translation available.
AC004802 Genomic DNA. No translation available.
AC004803 Genomic DNA. No translation available.
AC004804 Genomic DNA. No translation available.
AC006561 Genomic DNA. No translation available.
AC092469 Genomic DNA. No translation available.
AC234852 Genomic DNA. No translation available.
KC877502 Genomic DNA. No translation available.
KF455581 Genomic DNA. No translation available.
RefSeqiXP_011519246.1. XM_011520944.1.
UniGeneiHs.601216.

3D structure databases

ProteinModelPortaliX6RM00.
SMRiX6RM00. Positions 144-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354158.

Proteomic databases

EPDiX6RM00.
PaxDbiX6RM00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000542302; ENSP00000445336; ENSG00000082805.
ENST00000634904; ENSP00000489414; ENSG00000283017.
GeneIDi23085.
UCSCiuc058jrb.1. human.

Organism-specific databases

CTDi23085.
HGNCiHGNC:17072. ERC1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4809. Eukaryota.
ENOG410Y4GU. LUCA.
GeneTreeiENSGT00650000093320.

Miscellaneous databases

ChiTaRSiERC1. human.
GenomeRNAii23085.

Gene expression databases

ExpressionAtlasiX6RM00. baseline and differential.

Family and domain databases

InterProiIPR019323. ELKS/CAST.
[Graphical view]
PANTHERiPTHR18861. PTHR18861. 2 hits.
PfamiPF10174. Cast. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A., null.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Ensembl
    Submitted (APR-2014) to UniProtKB
    Cited for: IDENTIFICATION.
  10. Ensembl
    Submitted (DEC-2015) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiX6RM00_HUMAN
AccessioniPrimary (citable) accession number: X6RM00
Entry historyi
Integrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: June 8, 2016
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.