trpS

Functionⁱ

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityⁱ

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotationSAAS annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	166	L-tryptophanUniRule annotation		1
Binding siteⁱ	221	ATP; via amide nitrogen and carbonyl oxygenUniRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	41 – 43	ATPUniRule annotation	3
Nucleotide bindingⁱ	49 – 50	ATPUniRule annotation	2
Nucleotide bindingⁱ	178 – 180	ATPUniRule annotation	3
Nucleotide bindingⁱ	230 – 234	ATPUniRule annotation	5

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-UniRule
tryptophan-tRNA ligase activity Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

tryptophanyl-tRNA aminoacylation Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase
Biological process	Protein biosynthesisUniRule annotationSAAS annotation
Ligand	ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation) Alternative name(s): Tryptophanyl-tRNA synthetaseUniRule annotation Short name: TrpRSUniRule annotation
Gene namesⁱ	Name:trpSUniRule annotation ORF Names:P746_00790Imported
Organismⁱ	Enterococcus faecalis CBRD01Imported
Taxonomic identifierⁱ	1400521 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Lactobacillales › Enterococcaceae › Enterococcus › Enterococcus faecalis
Proteomesⁱ	UP000025027 Componentⁱ: Unassembled WGS sequence

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_00140

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	42 – 50	"HIGH" regionUniRule annotation		9
Motifⁱ	230 – 234	"KMSKS" regionUniRule annotation		5

Sequence similaritiesⁱ

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotationSAAS annotation

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00806. TrpRS_core. 1 hit.
Gene3Dⁱ	3.40.50.620. 2 hits.
HAMAPⁱ	MF_00140_B. Trp_tRNA_synth_B. 1 hit.
InterProⁱ	View protein in InterPro IPR001412. aa-tRNA-synth_I_CS. IPR002305. aa-tRNA-synth_Ic. IPR014729. Rossmann-like_a/b/a_fold. IPR002306. Trp-tRNA-ligase. IPR024109. Trp-tRNA-ligase_bac-type.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00579. tRNA-synt_1b. 1 hit.
PRINTSⁱ	PR01039. TRNASYNTHTRP.
TIGRFAMsⁱ	TIGR00233. trpS. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

X5NYC2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVIFQEVPMY FFLIKCIIEL FTILSLKSGG YLMKTIFSGI QPSGTPTIGN 
        60         70         80         90        100
YIGAMKQFIE LQNEYNCYFC IVDEHAITVP QEPQKLRQQI RSLAALYLAV 
       110        120        130        140        150
GLDPQKATIF IQSEVSAHAE AGWIIQCNTS IGELERMTQF KDKSQKNGRA 
       160        170        180        190        200
GVSAGLLTYP PLMVGDIVLY NADLVPVGDD QKQHLELTRD FVERFNKRYA 
       210        220        230        240        250
QKNQEILTMP EVKIAEQGSR IMSLQEPTKK MSKSDTNVKG FISMLDEPAV 
       260        270        280        290        300
IRKKIRSAVT DSTGVIEYNK EEKPGITNLL NIYSAATGQT VEELVQAYEG 
       310        320        330        340        350
KGYGDFKADL AEAVVALLEP IQVRYQELLA SEELDMILDE GAENARLVAN 
       360 
KTLQRMKNAV GLGRKVRR

Length:368

Mass (Da):41,204

Last modified:June 11, 2014 - v1

Checksum:ⁱB1722DBA28979B94

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AWYG01000006 Genomic DNA. Translation: ESU75121.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AWYG01000006 Genomic DNA. Translation: ESU75121.1.

Genome annotation databases

EnsemblBacteriaⁱ	ESU75121; ESU75121; P746_00790.

EnsemblBacteriaⁱ

ESU75121; ESU75121; P746_00790.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
X5NYC2	A0A2G9QSN1 A0A0E9EFX6 C7VB55 A0A0M2A985	Enterococcus faecalis (Streptococcus faecalis) Chlamydia trachomatis Enterococcus faecalis CH188 Enterococcus faecalis EnGen0302	368	UniRef100_X5NYC2	Cluster: Tryptophan--tRNA ligase	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
X5NYC2	Q830U2 A0A0U1ALT8 A0A2I2BZZ7 U6S5N2 S4FSH9 E6IAH7 E6H6L8 E6GXT3 A0A059N2D3 S4FAV6 +64	Enterococcus faecalis (strain ATCC 700802 / V583) Mycobacterium abscessus Enterococcus faecalis (Streptococcus faecalis) Enterococcus faecalis VC1B-1 Enterococcus faecalis WKS-26-18-2 Enterococcus faecalis TX0645 Enterococcus faecalis TX0309B Enterococcus faecalis TX0309A Enterococcus faecalis 918 Enterococcus faecium SB2C-2 And more	336	UniRef90_Q830U2	Cluster: Tryptophan--tRNA ligase	75

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
X5NYC2	P00953 UPI0002380B67 A0A178U0E7 UPI000716C81A UPI0001927A9E V6VIU1 A0A0K2HBK2 S7T126 A0A1V9CEY8 A0A250DWL1 +2817	Geobacillus stearothermophilus (Bacillus stearothermophilus) synthetic construct Geobacillus sp. MAS1 Geobacillus stearothermophilus 10 Geobacillus sp. WSUCF1 Geobacillus thermocatenulatus Geobacillus jurassicus Geobacillus sp. FJAT-46040 Geobacillus sp. GHH01 Geobacillus sp. 1017 And more	328	UniRef50_P00953	Cluster: Tryptophan--tRNA ligase	2,828

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AWYG01000006 Genomic DNA. Translation: ESU75121.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AWYG01000006 Genomic DNA. Translation: ESU75121.1.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ESU75121; ESU75121; P746_00790.

EnsemblBacteriaⁱ

ESU75121; ESU75121; P746_00790.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00806. TrpRS_core. 1 hit.
Gene3Dⁱ	3.40.50.620. 2 hits.
HAMAPⁱ	MF_00140_B. Trp_tRNA_synth_B. 1 hit.
InterProⁱ	View protein in InterPro IPR001412. aa-tRNA-synth_I_CS. IPR002305. aa-tRNA-synth_Ic. IPR014729. Rossmann-like_a/b/a_fold. IPR002306. Trp-tRNA-ligase. IPR024109. Trp-tRNA-ligase_bac-type.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00579. tRNA-synt_1b. 1 hit.
PRINTSⁱ	PR01039. TRNASYNTHTRP.
TIGRFAMsⁱ	TIGR00233. trpS. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00178. AA_TRNA_LIGASE_I. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	X5NYC2_ENTFL
Accessionⁱ	X5NYC2Primary (citable) accession number: X5NYC2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 11, 2014
	Last sequence update:	June 11, 2014
	Last modified:	March 28, 2018
	This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termⁱ

Complete proteomeImported

UniProtKB - X5NYC2 (X5NYC2_ENTFL)

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Tryptophan--tRNA ligase

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

Sites

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

Subunit structureⁱ

Family & Domainsⁱ

Motif

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Caution

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - X5NYC2 (X5NYC2_ENTFL)

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Tryptophan--tRNA ligase

trpS

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ