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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Enterococcus faecalis CBRD01
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei166L-tryptophanUniRule annotation1
Binding sitei221ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 43ATPUniRule annotation3
Nucleotide bindingi49 – 50ATPUniRule annotation2
Nucleotide bindingi178 – 180ATPUniRule annotation3
Nucleotide bindingi230 – 234ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
ORF Names:P746_00790Imported
OrganismiEnterococcus faecalis CBRD01Imported
Taxonomic identifieri1400521 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000025027 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50"HIGH" regionUniRule annotation9
Motifi230 – 234"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00806. TrpRS_core. 1 hit.
Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00140_B. Trp_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
PfamiView protein in Pfam
PF00579. tRNA-synt_1b. 1 hit.
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

X5NYC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIFQEVPMY FFLIKCIIEL FTILSLKSGG YLMKTIFSGI QPSGTPTIGN
60 70 80 90 100
YIGAMKQFIE LQNEYNCYFC IVDEHAITVP QEPQKLRQQI RSLAALYLAV
110 120 130 140 150
GLDPQKATIF IQSEVSAHAE AGWIIQCNTS IGELERMTQF KDKSQKNGRA
160 170 180 190 200
GVSAGLLTYP PLMVGDIVLY NADLVPVGDD QKQHLELTRD FVERFNKRYA
210 220 230 240 250
QKNQEILTMP EVKIAEQGSR IMSLQEPTKK MSKSDTNVKG FISMLDEPAV
260 270 280 290 300
IRKKIRSAVT DSTGVIEYNK EEKPGITNLL NIYSAATGQT VEELVQAYEG
310 320 330 340 350
KGYGDFKADL AEAVVALLEP IQVRYQELLA SEELDMILDE GAENARLVAN
360
KTLQRMKNAV GLGRKVRR
Length:368
Mass (Da):41,204
Last modified:June 11, 2014 - v1
Checksum:iB1722DBA28979B94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AWYG01000006 Genomic DNA. Translation: ESU75121.1.

Genome annotation databases

EnsemblBacteriaiESU75121; ESU75121; P746_00790.

Similar proteinsi

Entry informationi

Entry nameiX5NYC2_ENTFL
AccessioniPrimary (citable) accession number: X5NYC2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: March 28, 2018
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported