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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Streptococcus agalactiae
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei599For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
ORF Names:AX245_09110Imported, DX05_05355Imported, EN72_05315Imported, GT95_05155Imported, RDF_0928Imported, SA111_01055Imported, WA34_17955Imported
OrganismiStreptococcus agalactiaeImported
Taxonomic identifieri1311 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000093122 Componenti: Unassembled WGS sequence
  • UP000095406 Componenti: Chromosome i
  • UP000031749 Componenti: Chromosome
  • UP000035620 Componenti: Unassembled WGS sequence
  • UP000028184 Componenti: Chromosome
  • UP000035305 Componenti: Chromosome
  • UP000197890 Componenti: Chromosome

Subcellular locationi

X5K1Q4:
  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi211110.gbs0933.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 218Glutamine amidotransferase type-2InterPro annotationAdd BLAST217
Domaini284 – 423SISInterPro annotationAdd BLAST140
Domaini456 – 594SISInterPro annotationAdd BLAST139

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
KOiK00820.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

X5K1Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGVVGN TNATDILIQG LEKLEYRGYD SAGIFVVGDN KSQLVKSVGR
60 70 80 90 100
IAELQAKVGD SVSGTTGIGH TRWATHGKPT EGNAHPHTSG SGRFVLVHNG
110 120 130 140 150
VIENYLQIKE TYLTKHNLKG ETDTEIAIHL VEHFVEEDNL SVLEAFKKAL
160 170 180 190 200
HIIEGSYAFA LIDSQDADTI YVAKNKSPLL IGLGNGYNMV CSDAMAMIRE
210 220 230 240 250
TSEYMEIHDK ELVIVKKDSV EVQDYDGNVI ERGSYTAELD LSDIGKGTYP
260 270 280 290 300
FYMLKEIDEQ PTVMRKLIST YANESGDMNV DSDIIKSVQE ADRLYILAAG
310 320 330 340 350
TSYHAGFAAK TMIEKLTDTP VELGVSSEWG YNMPLLSKKP MFILLSQSGE
360 370 380 390 400
TADSRQVLVK ANEMGIPSLT ITNVPGSTLS REATYTMLIH AGPEIAVAST
410 420 430 440 450
KAYTAQVATL AFLAKAVGEA NGKAEAKDFD LVHELSIVAQ SIEATLSEKD
460 470 480 490 500
VISEKVEQLL ISTRNAFYIG RGNDYYVTME AALKLKEISY IQTEGFAAGE
510 520 530 540 550
LKHGTISLIE DNTPVIALIS ADSTIAAHTR GNIQEVVSRG ANALIIVEEG
560 570 580 590 600
LEREGDDIIV NKVHPFLSAI SMVIPTQLIA YYASLQRGLD VDKPRNLAKA

VTVE
Length:604
Mass (Da):65,636
Last modified:June 11, 2014 - v1
Checksum:i1342FAF91B474081
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP007631 Genomic DNA. Translation: AIF86503.1.
CP007572 Genomic DNA. Translation: AIK75667.1.
CP010867 Genomic DNA. Translation: AKI95343.1.
CP008813 Genomic DNA. Translation: ASI66006.1.
LT545678 Genomic DNA. Translation: CZT39169.1.
LBKE01000074 Genomic DNA. Translation: KLL20727.1.
MAWT01000010 Genomic DNA. Translation: OCM72220.1.
RefSeqiWP_000334317.1. NZ_NDGA01000018.1.

Genome annotation databases

EnsemblBacteriaiAIF86503; AIF86503; EN72_05315.
AIK75667; AIK75667; DX05_05355.
AKI95343; AKI95343; RDF_0928.
AOQ20461; AOQ20461; BBP08_04020.
CND70285; CND70285; ERS039640_00408.
CZT39169; CZT39169; SA111_01055.
KLL20727; KLL20727; WA34_17955.
OCM72220; OCM72220; AX245_09110.
ODG95418; ODG95418; TH70_0223.
KEGGisage:EN72_05315.
PATRICifig|1311.1180.peg.1004.

Similar proteinsi

Entry informationi

Entry nameiX5K1Q4_STRAG
AccessioniPrimary (citable) accession number: X5K1Q4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: October 25, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported