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X5DR79

- X5DR79_HUMAN

UniProt

X5DR79 - X5DR79_HUMAN

Protein
Submitted name:

Parkinson protein 2 isoform A

Gene

PARK2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 4 (01 Oct 2014)
      Sequence version 1 (11 Jun 2014)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ubiquitin-protein transferase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Parkinson protein 2 isoform AImported
    Gene namesi
    Name:PARK2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: InterPro
    2. mitochondrion Source: InterPro

    Structurei

    3D structure databases

    SMRiX5DR79. Positions 1-76, 141-465.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    PhylomeDBiX5DR79.

    Family and domain databases

    InterProiIPR003977. Parkin.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR002867. Znf_C6HC.
    [Graphical view]
    PfamiPF01485. IBR. 2 hits.
    PF00240. ubiquitin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037880. Parkin. 1 hit.
    PRINTSiPR01475. PARKIN.
    SMARTiSM00647. IBR. 2 hits.
    SM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    X5DR79-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL    50
    RNDWTVQNCD LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ 100
    SLTRVDLSSS VLPGDSVGLA VILHTDSRKD SPPAGSPAGR SIYNSFYVYC 150
    KGPCQRVQPG KLRVQCSTCR QATLTLTQGP SCWDDVLIPN RMSGECQSPH 200
    CPGTSAEFFF KCGAHPTSDK ETSVALHLIA TNSRNITCIT CTDVRSPVLV 250
    FQCNSRHVIC LDCFHLYCVT RLNDRQFVHD PQLGYSLPCV AGCPNSLIKE 300
    LHHFRILGEE QYNRYQQYGA EECVLQMGGV LCPRPGCGAG LLPEPDQRKV 350
    TCEGGNGLGC GFAFCRECKE AYHEGECSAV FEASGTTTQA YRVDERAAEQ 400
    ARWEAASKET IKKTTKPCPR CHVPVEKNGG CMHMKCPQPQ CRLEWCWNCG 450
    CEWNRVCMGD HWFDV 465
    Length:465
    Mass (Da):51,641
    Last modified:June 11, 2014 - v1
    Checksum:i9A8BB802A3FC84C3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei465 – 4651Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    KJ534912 mRNA. Translation: AHW56552.1.
    RefSeqiNP_004553.2. NM_004562.2.

    Genome annotation databases

    GeneIDi5071.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    KJ534912 mRNA. Translation: AHW56552.1 .
    RefSeqi NP_004553.2. NM_004562.2.

    3D structure databases

    SMRi X5DR79. Positions 1-76, 141-465.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5071.

    Phylogenomic databases

    PhylomeDBi X5DR79.

    Family and domain databases

    InterProi IPR003977. Parkin.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR002867. Znf_C6HC.
    [Graphical view ]
    Pfami PF01485. IBR. 2 hits.
    PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037880. Parkin. 1 hit.
    PRINTSi PR01475. PARKIN.
    SMARTi SM00647. IBR. 2 hits.
    SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism."
      Corominas R., Yang X., Lin G.N., Kang S., Shen Y., Ghamsari L., Broly M., Rodriguez M., Tam S., Wanamaker S.A., Fan C., Yi S., Tasan M., Lemmens I., Kuang X., Zhao N., Malhotra D., Michaelson J.J.
      , Vacic V., Calderwood M.A., Roth F.P., Tavernier J., Horvath S., Salehi-Ashtiani K., Korkin D., Sebat J., Hill D.E., Hao T., Vidal M., Iakoucheva L.M.
      Nat. Commun. 5:3650-3650(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Fetal whole brainImported.

    Entry informationi

    Entry nameiX5DR79_HUMAN
    AccessioniPrimary (citable) accession number: X5DR79
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 11, 2014
    Last sequence update: June 11, 2014
    Last modified: October 1, 2014
    This is version 4 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.