Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

X5DR79

- X5DR79_HUMAN

UniProt

X5DR79 - X5DR79_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Parkinson protein 2 isoform A

Gene

PARK2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ubiquitin-protein transferase activity Source: Ensembl
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. cellular protein catabolic process Source: Ensembl
  3. dopamine metabolic process Source: Ensembl
  4. dopamine uptake involved in synaptic transmission Source: Ensembl
  5. learning Source: Ensembl
  6. norepinephrine metabolic process Source: Ensembl
  7. regulation of neurotransmitter secretion Source: Ensembl
  8. startle response Source: Ensembl
  9. synaptic transmission, glutamatergic Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Parkinson protein 2 isoform AImported
Gene namesi
Name:PARK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: InterPro
  2. mitochondrion Source: InterPro
  3. neuron projection Source: Ensembl
  4. nucleus Source: Ensembl
  5. protein complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiX5DR79. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliX5DR79.
SMRiX5DR79. Positions 1-76, 141-465.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00390000011034.
KOiK04556.
PhylomeDBiX5DR79.

Family and domain databases

InterProiIPR003977. Parkin.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR002867. Znf_C6HC.
[Graphical view]
PfamiPF01485. IBR. 2 hits.
PF00240. ubiquitin. 1 hit.
[Graphical view]
PIRSFiPIRSF037880. Parkin. 1 hit.
PRINTSiPR01475. PARKIN.
SMARTiSM00647. IBR. 2 hits.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

X5DR79-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL
60 70 80 90 100
RNDWTVQNCD LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ
110 120 130 140 150
SLTRVDLSSS VLPGDSVGLA VILHTDSRKD SPPAGSPAGR SIYNSFYVYC
160 170 180 190 200
KGPCQRVQPG KLRVQCSTCR QATLTLTQGP SCWDDVLIPN RMSGECQSPH
210 220 230 240 250
CPGTSAEFFF KCGAHPTSDK ETSVALHLIA TNSRNITCIT CTDVRSPVLV
260 270 280 290 300
FQCNSRHVIC LDCFHLYCVT RLNDRQFVHD PQLGYSLPCV AGCPNSLIKE
310 320 330 340 350
LHHFRILGEE QYNRYQQYGA EECVLQMGGV LCPRPGCGAG LLPEPDQRKV
360 370 380 390 400
TCEGGNGLGC GFAFCRECKE AYHEGECSAV FEASGTTTQA YRVDERAAEQ
410 420 430 440 450
ARWEAASKET IKKTTKPCPR CHVPVEKNGG CMHMKCPQPQ CRLEWCWNCG
460
CEWNRVCMGD HWFDV
Length:465
Mass (Da):51,641
Last modified:June 11, 2014 - v1
Checksum:i9A8BB802A3FC84C3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei465 – 4651Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ534912 mRNA. Translation: AHW56552.1.
RefSeqiNP_004553.2. NM_004562.2.
UniGeneiHs.132954.

Genome annotation databases

GeneIDi5071.
KEGGihsa:5071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ534912 mRNA. Translation: AHW56552.1 .
RefSeqi NP_004553.2. NM_004562.2.
UniGenei Hs.132954.

3D structure databases

ProteinModelPortali X5DR79.
SMRi X5DR79. Positions 1-76, 141-465.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5071.
KEGGi hsa:5071.

Organism-specific databases

CTDi 5071.

Phylogenomic databases

GeneTreei ENSGT00390000011034.
KOi K04556.
PhylomeDBi X5DR79.

Gene expression databases

ExpressionAtlasi X5DR79. baseline and differential.

Family and domain databases

InterProi IPR003977. Parkin.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR002867. Znf_C6HC.
[Graphical view ]
Pfami PF01485. IBR. 2 hits.
PF00240. ubiquitin. 1 hit.
[Graphical view ]
PIRSFi PIRSF037880. Parkin. 1 hit.
PRINTSi PR01475. PARKIN.
SMARTi SM00647. IBR. 2 hits.
SM00213. UBQ. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS50053. UBIQUITIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism."
    Corominas R., Yang X., Lin G.N., Kang S., Shen Y., Ghamsari L., Broly M., Rodriguez M., Tam S., Wanamaker S.A., Fan C., Yi S., Tasan M., Lemmens I., Kuang X., Zhao N., Malhotra D., Michaelson J.J.
    , Vacic V., Calderwood M.A., Roth F.P., Tavernier J., Horvath S., Salehi-Ashtiani K., Korkin D., Sebat J., Hill D.E., Hao T., Vidal M., Iakoucheva L.M.
    Nat. Commun. 5:3650-3650(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Fetal whole brainImported.

Entry informationi

Entry nameiX5DR79_HUMAN
AccessioniPrimary (citable) accession number: X5DR79
Entry historyi
Integrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: November 26, 2014
This is version 6 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.