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Protein
Submitted name:

Neuronal PAS domain protein 3 isoform D

Gene

NPAS3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Neuronal PAS domain protein 3 isoform DImported
Gene namesi
Name:NPAS3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiX5D988.
PRIDEiX5D988.

Expressioni

Gene expression databases

ExpressionAtlasiX5D988. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348460.

Structurei

3D structure databases

ProteinModelPortaliX5D988.
SMRiX5D988.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 74BHLH (basic helix-loop-helix)InterPro annotationAdd BLAST54
Domaini123 – 187PAS (PER-ARNT-SIM)InterPro annotationAdd BLAST65
Domaini304 – 359PAS (PER-ARNT-SIM)InterPro annotationAdd BLAST56

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]
PfamiPF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

X5D988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTKPSFQQ DPSRRERLQA LRKEKSRDAA RSRRGKENFE FYELAKLLPL
60 70 80 90 100
PAAITSQLDK ASIIRLTISY LKMRDFANQG DPPWNLRMEG PPPNTSVKVI
110 120 130 140 150
GAQRRRSPSA LAIEVFEAHL GSHILQSLDG FVFALNQEGK FLYISETVSI
160 170 180 190 200
YLGLSQVELT GSSVFDYVHP GDHVEMAEQL GMKLPPGRGL LSQGTAEDGA
210 220 230 240 250
SSASSSSQSE TPEPVESTSP SLLTTDNTLE RSFFIRMKST LTKRGVHIKS
260 270 280 290 300
SGYKVIHITG RLRLRVSLSH GRTVPSQIMG LVVVAHALPP PTINEVRIDC
310 320 330 340 350
HMFVTRVNMD LNIIYCENRI SDYMDLTPVD IVGKRCYHFI HAEDVEGIRH
360 370 380 390 400
SHLDLLNKGQ CVTKYYRWMQ KNGGYIWIQS SATIAINAKN ANEKNIIWVN
410 420 430 440 450
YLLSNPEYKD TPMDIAQLPH LPEKTSESSE TSDSESDSKD TSGITEDNEN
460 470 480 490 500
SKSDEKGNQS ENSEDPEPDR KKSGNACDND MNCNDDGHSS SNPDSRDSDD
510 520 530 540 550
SFEHSDFENP KAGEDGFGAL GAMQIKVERY VESESDLRLQ NCESLTSDSA
560 570 580 590 600
KDSDSAGEAG AQASSKHQKR KKRRKRQKGG SASRRRLSSA SSPGGLDAGL
610 620 630 640 650
VEPPRLLSSP NSASVLKIKT EISEPINFDN DSSIWNYPPN REISRNESPY
660 670 680 690 700
SMTKPPSSEH FPSPQGGGGG GGGGGGLHVA IPDSVLTPPG ADGAAARKTQ
710 720 730 740 750
FGASATAALA PVASDPLSPP LSASPRDKHP GNGGGGGGGG GGAGGGGPSA
760 770 780 790 800
SNSLLYTGDL EALQRLQAGN VVLPLVHRVT GTLAATSTAA QRVYTTGTIR
810 820 830 840 850
YAPAEVTLAM QSNLLPNAHA VNFVDVNSPG FGLDPKTPME MLYHHVHRLN
860 870 880 890 900
MSGPFGGAVS AASLTQMPAG NVFTTAEGLF STLPFPVYSN GIHAAQTLER

KED
Length:903
Mass (Da):97,231
Last modified:June 11, 2014 - v1
Checksum:iEF48D82F79966428
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei903Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ534898 mRNA. Translation: AHW56538.1.
RefSeqiNP_001159365.1. NM_001165893.1.
UniGeneiHs.657892.
Hs.675437.
Hs.675475.

Genome annotation databases

GeneIDi64067.
UCSCiuc001wrv.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ534898 mRNA. Translation: AHW56538.1.
RefSeqiNP_001159365.1. NM_001165893.1.
UniGeneiHs.657892.
Hs.675437.
Hs.675475.

3D structure databases

ProteinModelPortaliX5D988.
SMRiX5D988.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348460.

Proteomic databases

PaxDbiX5D988.
PRIDEiX5D988.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64067.
UCSCiuc001wrv.4. human.

Organism-specific databases

CTDi64067.

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.

Miscellaneous databases

ChiTaRSiNPAS3. human.
GenomeRNAii64067.

Gene expression databases

ExpressionAtlasiX5D988. baseline and differential.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]
PfamiPF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiX5D988_HUMAN
AccessioniPrimary (citable) accession number: X5D988
Entry historyi
Integrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: November 30, 2016
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.