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Protein
Submitted name:

Neuronal PAS domain protein 3 isoform A

Gene

NPAS3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Neuronal PAS domain protein 3 isoform AImported
Gene namesi
Name:NPAS3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiX5D2Q4.

Expressioni

Gene expression databases

ExpressionAtlasiX5D2Q4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348460.

Structurei

3D structure databases

ProteinModelPortaliX5D2Q4.
SMRiX5D2Q4. Positions 52-437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 10454BHLH (basic helix-loop-helix)InterPro annotationAdd
BLAST
Domaini153 – 21765PAS (PER-ARNT-SIM)InterPro annotationAdd
BLAST
Domaini334 – 38956PAS (PER-ARNT-SIM)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation
Contains bHLH (basic helix-loop-helix) domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.
KOiK09098.
PhylomeDBiX5D2Q4.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]
PfamiPF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

X5D2Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTKPSFQQ DPSRRERITA QHPLPNQSEC RKIYRYDGIY CESTYQNLQA
60 70 80 90 100
LRKEKSRDAA RSRRGKENFE FYELAKLLPL PAAITSQLDK ASIIRLTISY
110 120 130 140 150
LKMRDFANQG DPPWNLRMEG PPPNTSVKVI GAQRRRSPSA LAIEVFEAHL
160 170 180 190 200
GSHILQSLDG FVFALNQEGK FLYISETVSI YLGLSQVELT GSSVFDYVHP
210 220 230 240 250
GDHVEMAEQL GMKLPPGRGL LSQGTAEDGA SSASSSSQSE TPEPVESTSP
260 270 280 290 300
SLLTTDNTLE RSFFIRMKST LTKRGVHIKS SGYKVIHITG RLRLRVSLSH
310 320 330 340 350
GRTVPSQIMG LVVVAHALPP PTINEVRIDC HMFVTRVNMD LNIIYCENRI
360 370 380 390 400
SDYMDLTPVD IVGKRCYHFI HAEDVEGIRH SHLDLLNKGQ CVTKYYRWMQ
410 420 430 440 450
KNGGYIWIQS SATIAINAKN ANEKNIIWVN YLLSNPEYKD TPMDIAQLPH
460 470 480 490 500
LPEKTSESSE TSDSESDSKD TSGITEDNEN SKSDEKGNQS ENSEDPEPDR
510 520 530 540 550
KKSGNACDND MNCNDDGHSS SNPDSRDSDD SFEHSDFENP KAGEDGFGAL
560 570 580 590 600
GAMQIKVERY VESESDLRLQ NCESLTSDSA KDSDSAGEAG AQASSKHQKR
610 620 630 640 650
KKRRKRQKGG SASRRRLSSA SSPGGLDAGL VEPPRLLSSP NSASVLKIKT
660 670 680 690 700
EISEPINFDN DSSIWNYPPN REISRNESPY SMTKPPSSEH FPSPQGGGGG
710 720 730 740 750
GGGGGGLHVA IPDSVLTPPG ADGAAARKTQ FGASATAALA PVASDPLSPP
760 770 780 790 800
LSASPRDKHP GNGGGGGGGG GGAGGGGPSA SNSLLYTGDL EALQRLQAGN
810 820 830 840 850
VVLPLVHRVT GTLAATSTAA QRVYTTGTIR YAPAEVTLAM QSNLLPNAHA
860 870 880 890 900
VNFVDVNSPG FGLDPKTPME MLYHHVHRLN MSGPFGGAVS AASLTQMPAG
910 920 930
NVFTTAEGLF STLPFPVYSN GIHAAQTLER KED
Length:933
Mass (Da):100,805
Last modified:June 11, 2014 - v1
Checksum:i3215AC657CEDD9A9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei933 – 9331Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ534894 mRNA. Translation: AHW56534.1.
RefSeqiNP_001158221.1. NM_001164749.1.
UniGeneiHs.657892.
Hs.675437.
Hs.675475.

Genome annotation databases

GeneIDi64067.
KEGGihsa:64067.
UCSCiuc001wru.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ534894 mRNA. Translation: AHW56534.1.
RefSeqiNP_001158221.1. NM_001164749.1.
UniGeneiHs.657892.
Hs.675437.
Hs.675475.

3D structure databases

ProteinModelPortaliX5D2Q4.
SMRiX5D2Q4. Positions 52-437.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348460.

Proteomic databases

PaxDbiX5D2Q4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64067.
KEGGihsa:64067.
UCSCiuc001wru.4. human.

Organism-specific databases

CTDi64067.

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.
KOiK09098.
PhylomeDBiX5D2Q4.

Miscellaneous databases

ChiTaRSiNPAS3. human.
GenomeRNAii64067.

Gene expression databases

ExpressionAtlasiX5D2Q4. baseline and differential.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]
PfamiPF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiX5D2Q4_HUMAN
AccessioniPrimary (citable) accession number: X5D2Q4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: September 7, 2016
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.