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Protein
Submitted name:

Hydroxysteroid 11-beta dehydrogenase 1 isoform A

Gene

HSD11B1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Hydroxysteroid 11-beta dehydrogenase 1 isoform AImported
Gene namesi
Name:HSD11B1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2317HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiX5D2L1.
PaxDbiX5D2L1.

Expressioni

Gene expression databases

ExpressionAtlasiX5D2L1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000261465.

Structurei

3D structure databases

ProteinModelPortaliX5D2L1.
SMRiX5D2L1. Positions 24-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00840000129712.
KOiK15680.
OMAiGLFMAYY.
PhylomeDBiX5D2L1.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

X5D2L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFMKKYLLP ILGLFMAYYY YSANEEFRPE MLQGKKVIVT GASKGIGREM
60 70 80 90 100
AYHLAKMGAH VVVTARSKET LQKVVSHCLE LGAASAHYIA GTMEDMTFAE
110 120 130 140 150
QFVAQAGKLM GGLDMLILNH ITNTSLNLFH DDIHHVRKSM EVNFLSYVVL
160 170 180 190 200
TVAALPMLKQ SNGSIVVVSS LAGKVAYPMV AAYSASKFAL DGFFSSIRKE
210 220 230 240 250
YSVSRVNVSI TLCVLGLIDT ETAMKAVSGI VHMQAAPKEE CALEIIKGGA
260 270 280 290
LRQEEVYYDS SLWTTLLIRN PCRKILEFLY STSYNMDRFI NK
Length:292
Mass (Da):32,401
Last modified:June 11, 2014 - v1
Checksum:i4632D0F3BBEFC474
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei292 – 2921Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ534869 mRNA. Translation: AHW56509.1.
RefSeqiNP_001193670.1. NM_001206741.1.
NP_005516.1. NM_005525.3.
NP_861420.1. NM_181755.2.
UniGeneiHs.195040.

Genome annotation databases

GeneIDi3290.
KEGGihsa:3290.
UCSCiuc001hhk.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ534869 mRNA. Translation: AHW56509.1.
RefSeqiNP_001193670.1. NM_001206741.1.
NP_005516.1. NM_005525.3.
NP_861420.1. NM_181755.2.
UniGeneiHs.195040.

3D structure databases

ProteinModelPortaliX5D2L1.
SMRiX5D2L1. Positions 24-292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000261465.

Proteomic databases

MaxQBiX5D2L1.
PaxDbiX5D2L1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3290.
KEGGihsa:3290.
UCSCiuc001hhk.4. human.

Organism-specific databases

CTDi3290.

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00840000129712.
KOiK15680.
OMAiGLFMAYY.
PhylomeDBiX5D2L1.

Miscellaneous databases

ChiTaRSiHSD11B1. human.
GenomeRNAii3290.

Gene expression databases

ExpressionAtlasiX5D2L1. baseline and differential.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism."
    Corominas R., Yang X., Lin G.N., Kang S., Shen Y., Ghamsari L., Broly M., Rodriguez M., Tam S., Wanamaker S.A., Fan C., Yi S., Tasan M., Lemmens I., Kuang X., Zhao N., Malhotra D., Michaelson J.J.
    , Vacic V., Calderwood M.A., Roth F.P., Tavernier J., Horvath S., Salehi-Ashtiani K., Korkin D., Sebat J., Hill D.E., Hao T., Vidal M., Iakoucheva L.M.
    Nat. Commun. 5:3650-3650(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Adult whole brainImported.

Entry informationi

Entry nameiX5D2L1_HUMAN
AccessioniPrimary (citable) accession number: X5D2L1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: May 11, 2016
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.