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Protein
Submitted name:

Hydroxysteroid 11-beta dehydrogenase 1 isoform A

Gene

HSD11B1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Hydroxysteroid 11-beta dehydrogenase 1 isoform AImported
Gene namesi
Name:HSD11B1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 23HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiX5D2L1.
PaxDbiX5D2L1.

Expressioni

Gene expression databases

BgeeiENSG00000117594.
ExpressionAtlasiX5D2L1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliX5D2L1.
SMRiX5D2L1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
KOiK15680.
OMAiIGREMAY.
OrthoDBiEOG091G0H0R.
PhylomeDBiX5D2L1.

Family and domain databases

InterProiView protein in InterPro
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Fragment.

X5D2L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFMKKYLLP ILGLFMAYYY YSANEEFRPE MLQGKKVIVT GASKGIGREM
60 70 80 90 100
AYHLAKMGAH VVVTARSKET LQKVVSHCLE LGAASAHYIA GTMEDMTFAE
110 120 130 140 150
QFVAQAGKLM GGLDMLILNH ITNTSLNLFH DDIHHVRKSM EVNFLSYVVL
160 170 180 190 200
TVAALPMLKQ SNGSIVVVSS LAGKVAYPMV AAYSASKFAL DGFFSSIRKE
210 220 230 240 250
YSVSRVNVSI TLCVLGLIDT ETAMKAVSGI VHMQAAPKEE CALEIIKGGA
260 270 280 290
LRQEEVYYDS SLWTTLLIRN PCRKILEFLY STSYNMDRFI NK
Length:292
Mass (Da):32,401
Last modified:June 11, 2014 - v1
Checksum:i4632D0F3BBEFC474
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei292Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ534869 mRNA. Translation: AHW56509.1.
RefSeqiNP_001193670.1. NM_001206741.1.
NP_005516.1. NM_005525.3.
NP_861420.1. NM_181755.2.
UniGeneiHs.195040.

Genome annotation databases

GeneIDi3290.
KEGGihsa:3290.
UCSCiuc001hhk.4. human.

Similar proteinsi

Entry informationi

Entry nameiX5D2L1_HUMAN
AccessioniPrimary (citable) accession number: X5D2L1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: August 30, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.