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Protein

Gap junction protein

Gene

GJA5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction proteinUniRule annotation
Gene namesi
Name:GJA5Imported
ORF Names:hCG_1770483Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000265107.2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 41HelicalSequence analysisAdd BLAST22
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei205 – 227HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Gap junctionUniRule annotationSAAS annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSG00000265107.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.UniRule annotationSAAS annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 76CNXInterPro annotationAdd BLAST34
Domaini163 – 229Connexin_CCCInterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the connexin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IF3Z. Eukaryota.
ENOG410ZC96. LUCA.
KOiK07614.
OMAiYLLYGIF.
OrthoDBiEOG091G0FKH.

Family and domain databases

Gene3Di1.20.1440.80. 1 hit.
InterProiView protein in InterPro
IPR000500. Connexin.
IPR002264. Connexin40.
IPR034634. Connexin_C.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
IPR038359. Connexin_N_sf.
IPR031862. Cx40_C.
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF13. PTHR11984:SF13. 1 hit.
PfamiView protein in Pfam
PF00029. Connexin. 1 hit.
PF16791. Connexin40_C. 1 hit.
PRINTSiPR00206. CONNEXIN.
PR01135. CONNEXINA5.
SMARTiView protein in SMART
SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
SUPFAMiSSF118220. SSF118220. 1 hit.
PROSITEiView protein in PROSITE
PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

X5D2H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSFLGNF LEEVHKHSTV VGKVWLTVLF IFRMLVLGTA AESSWGDEQA
60 70 80 90 100
DFRCDTIQPG CQNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV
110 120 130 140 150
RMQEKRKLRE AERAKEVRGS GSYEYPVAEK AELSCWEEGN GRIALQGTLL
160 170 180 190 200
NTYVCSILIR TTMEVGFIVG QYFIYGIFLT TLHVCRRSPC PHPVNCYVSR
210 220 230 240 250
PTEKNVFIVF MLAVAALSLL LSLAELYHLG WKKIRQRFVK PRQHMAKCQL
260 270 280 290 300
SGPSVGIVQS CTPPPDFNQC LENGPGGKFF NPFSNNMASQ QNTDNLVTEQ
310 320 330 340 350
VRGQEQTPGE GFIQVRYGQK PEVPNGVSPG HRLPHGYHSD KRRLSKASSK

ARSDDLSV
Length:358
Mass (Da):40,380
Last modified:June 11, 2014 - v1
Checksum:iDE9DD863C130229A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei358Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ534844 mRNA. Translation: AHW56484.1.
CH471223 Genomic DNA. Translation: EAW50929.1.
CH471223 Genomic DNA. Translation: EAW50930.1.
RefSeqiNP_005257.2. NM_005266.6.
NP_859054.1. NM_181703.3.
XP_005273008.1. XM_005272951.4.
XP_016856533.1. XM_017001044.1.
UniGeneiHs.447968.

Genome annotation databases

GeneIDi2702.
KEGGihsa:2702.
UCSCiuc021ovl.2. human.

Similar proteinsi

Entry informationi

Entry nameiX5D2H9_HUMAN
AccessioniPrimary (citable) accession number: X5D2H9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: March 28, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.