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X5D2H2

- X5D2H2_HUMAN

UniProt

X5D2H2 - X5D2H2_HUMAN

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Protein
Submitted name:

Forkhead box P2 isoform B

Gene

FOXP2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl

GO - Biological processi

  1. camera-type eye development Source: Ensembl
  2. cerebellum development Source: Ensembl
  3. growth Source: Ensembl
  4. lung alveolus development Source: Ensembl
  5. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
  6. positive regulation of mesenchymal cell proliferation Source: Ensembl
  7. post-embryonic development Source: Ensembl
  8. righting reflex Source: Ensembl
  9. skeletal muscle tissue development Source: Ensembl
  10. smooth muscle tissue development Source: Ensembl
  11. vocal learning Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Forkhead box P2 isoform BImported
Submitted name:
Forkhead box P2, isoform CRA_eImported
Gene namesi
Name:FOXP2Imported
ORF Names:hCG_1813384Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Expressioni

Gene expression databases

ExpressionAtlasiX5D2H2. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Contains fork-head DNA-binding domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00750000117475.
KOiK09409.
PhylomeDBiX5D2H2.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

X5D2H2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL
60 70 80 90 100
HLQQQQALQA ARQLLLQQQT SGLKSPKSSD KQRPLQELLP ETKLCICGHS
110 120 130 140 150
SGDGHPHNTF AVPVSVAMMT PQVITPQQMQ QILQQQVLSP QQLQALLQQQ
160 170 180 190 200
QAVMLQQQQL QEFYKKQQEQ LHLQLLQQQQ QQQQQQQQQQ QQQQQQQQQQ
210 220 230 240 250
QQQQQQQQQQ QQQQQQHPGK QAKEQQQQQQ QQQQLAAQQL VFQQQLLQMQ
260 270 280 290 300
QLQQQQHLLS LQRQGLISIP PGQAALPVQS LPQAGLSPAE IQQLWKEVTG
310 320 330 340 350
VHSMEDNGIK HGGLDLTTNN SSSTTSSNTS KASPPITHHS IVNGQSSVLS
360 370 380 390 400
ARRDSSSHEE TGASHTLYGH GVCKWPGCES ICEDFGQFLK HLNNEHALDD
410 420 430 440 450
RSTAQCRVQM QVVQQLEIQL SKERERLQAM MTHLHMRPSE PKPSPKPLNL
460 470 480 490 500
VSSVTMSKNM LETSPQSLPQ TPTTPTAPVT PITQGPSVIT PASVPNVGAI
510 520 530 540 550
RRRHSDKYNI PMSSEIAPNY EFYKNADVRP PFTYATLIRQ AIMESSDRQL
560 570 580 590 600
TLNEIYSWFT RTFAYFRRNA ATWKNAVRHN LSLHKCFVRV ENVKGAVWTV
610 620 630 640 650
DEVEYQKRRS QKITGSPTLV KNIPTSLGYG AALNASLQAA LAESSLPLLS
660 670 680 690 700
NPGLINNASS GLLQAVHEDL NGSLDHIDSN GNSSPGCSPQ PHIHSIHVKE
710 720 730 740
EPVIAEDEDC PMSLVTTANH SPELEDDREI EEEPLSEDLE
Length:740
Mass (Da):82,565
Last modified:June 11, 2014 - v1
Checksum:i423EC421368FCD94
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei740 – 7401Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ534839 mRNA. Translation: AHW56479.1.
CH471070 Genomic DNA. Translation: EAW83483.1.
RefSeqiNP_683696.2. NM_148898.3.
UniGeneiHs.282787.

Genome annotation databases

GeneIDi93986.
KEGGihsa:93986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ534839 mRNA. Translation: AHW56479.1 .
CH471070 Genomic DNA. Translation: EAW83483.1 .
RefSeqi NP_683696.2. NM_148898.3.
UniGenei Hs.282787.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 93986.
KEGGi hsa:93986.

Organism-specific databases

CTDi 93986.

Phylogenomic databases

GeneTreei ENSGT00750000117475.
KOi K09409.
PhylomeDBi X5D2H2.

Miscellaneous databases

ChiTaRSi FOXP2. human.

Gene expression databases

ExpressionAtlasi X5D2H2. baseline and differential.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
PROSITEi PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism."
    Corominas R., Yang X., Lin G.N., Kang S., Shen Y., Ghamsari L., Broly M., Rodriguez M., Tam S., Wanamaker S.A., Fan C., Yi S., Tasan M., Lemmens I., Kuang X., Zhao N., Malhotra D., Michaelson J.J.
    , Vacic V., Calderwood M.A., Roth F.P., Tavernier J., Horvath S., Salehi-Ashtiani K., Korkin D., Sebat J., Hill D.E., Hao T., Vidal M., Iakoucheva L.M.
    Nat. Commun. 5:3650-3650(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Adult whole brainImported.

Entry informationi

Entry nameiX5D2H2_HUMAN
AccessioniPrimary (citable) accession number: X5D2H2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: November 26, 2014
This is version 6 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.