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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Klebsiella pneumoniae
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotationImported
ORF Names:AGG09_23545Imported, AM447_21675Imported, B5G58_05020Imported, BCB67_24475Imported, BL102_0010370Imported, BN49_3494Imported, KpST82_2601Imported, PMK1_04750Imported, SAMEA3304008_00213Imported, SAMEA3531778_01180Imported, SM57_02591Imported
OrganismiKlebsiella pneumoniaeImported
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000067608 Componenti: Chromosome
  • UP000053587 Componenti: Unassembled WGS sequence
  • UP000193429 Componenti: Chromosome
  • UP000037134 Componenti: Unassembled WGS sequence
  • UP000190083 Componenti: Chromosome
  • UP000029666 Componenti: Chromosome
  • UP000092889 Componenti: Unassembled WGS sequence
  • UP000032739 Componenti: Chromosome
  • UP000191926 Componenti: Unassembled WGS sequence
  • UP000186660 Componenti: Unassembled WGS sequence
  • UP000094167 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 87Arg_tRNA_synt_NInterPro annotationAdd BLAST87
Domaini460 – 577DALR_1InterPro annotationAdd BLAST118

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi122 – 132"HIGH" regionUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C75. Bacteria.
COG0018. LUCA.
KOiK01887.

Family and domain databases

CDDicd00671. ArgRS_core. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR035684. ArgRS_core.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiView protein in Pfam
PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
PRINTSiPR01038. TRNASYNTHARG.
SMARTiView protein in SMART
SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

W9B9W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIQALLSEK VSQALIAAGA PADCEPQVRQ SAKVQFGDYQ ANGVMAVAKK
60 70 80 90 100
LGMAPRQLAE QVLSHLDLNG IANKVEIAGP GFINIFLDPA FLADNVNRAL
110 120 130 140 150
QSERLGVTKP QAQTIVVDYS APNVAKEMHV GHLRSTIIGD ASVRTLEFLG
160 170 180 190 200
HKVIRANHVG DWGTQFGMLI AYLEKQQQEN AGEMALADLE GFYREAKKHY
210 220 230 240 250
DEDEAFAERA RSYVVKLQGG DEYFLQMWRK LVDITMSQNQ ITYDRLNVTL
260 270 280 290 300
TRDDVMGESL YNPMLPGIVA DLKAKGLAVE SEGATVVFLD EYKNKEGEPM
310 320 330 340 350
GVIIQKKDGG YLYTTTDIAC AKYRYETLHA DRVLYYIDSR QHQHLMQAWT
360 370 380 390 400
IVRKAGYVPD SVPLEHHMFG MMLGKDGKPF KTRAGGTVKL ADLLDEALER
410 420 430 440 450
ARRLVAEKNP DMSADELENL AKVVGIGAVK YADLSKNRTT DYVFDWDNML
460 470 480 490 500
AFEGNTAPYM QYAYTRVLSV FRKAGIDENA MIDAPVVIAE DREAQLAARL
510 520 530 540 550
LQFEETLSVV AREGTPHVMC AYLYDLAGLF SGFYEHCPIL SAESEETRNS
560 570
RLKLALLTAK TLKLGLDTLG IETVERM
Length:577
Mass (Da):64,242
Last modified:May 14, 2014 - v1
Checksum:i93D42215E0585926
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP008929 Genomic DNA. Translation: AIT04187.1.
CP013322 Genomic DNA. Translation: ALR27073.1.
CP020067 Genomic DNA. Translation: ARA48599.1.
CP020901 Genomic DNA. Translation: ARM21338.1.
FO834906 Genomic DNA. Translation: CDO15246.1.
LK022720 Genomic DNA. Translation: CDQ55376.1.
LGJJ01000011 Genomic DNA. Translation: KMW86368.1.
MCNO01000065 Genomic DNA. Translation: ODN19143.1.
MPXL03000035 Genomic DNA. Translation: OSW43640.1.
FLVW01000002 Genomic DNA. Translation: SBX63279.1.
FWGB01000001 Genomic DNA. Translation: SLN79827.1.
RefSeqiWP_004151452.1. NZ_NELT01000025.1.

Genome annotation databases

EnsemblBacteriaiAIT04187; AIT04187; PMK1_04750.
ALR27073; ALR27073; AGG09_23545.
CDO15246; CDO15246; BN49_3494.
ODN19143; ODN19143; BCB67_24475.
SBX63279; SBX63279; SAMEA3531778_01180.
KEGGikpne:KU54_009360.
kpnu:LI86_09315.
kpx:PMK1_04750.
PATRICifig|573.1346.peg.3171.

Similar proteinsi

Entry informationi

Entry nameiW9B9W2_KLEPN
AccessioniPrimary (citable) accession number: W9B9W2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 14, 2014
Last sequence update: May 14, 2014
Last modified: September 27, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported