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Protein

ATP-dependent RNA helicase DbpA

Gene

dbpA

Organism
Escherichia coli
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseUniRule annotationImported, Hydrolase, RNA-bindingUniRule annotation
Biological processRibosome biogenesisUniRule annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DbpAUniRule annotation (EC:3.6.4.13UniRule annotation)
Gene namesi
Name:dbpAUniRule annotationImported
ORF Names:A8C65_19820Imported, A9R57_00760Imported, ACU57_03180Imported, AM266_06865Imported, AM408_12060Imported, AUQ13_15600Imported, BHS87_08505Imported, BJJ90_11745Imported, BMT91_21590Imported, BUE81_14670Imported, BW690_11350Imported, BZL33_09410Imported, CA593_21090Imported, EC3234A_27c00310Imported, ERS085365_01924Imported, ERS085416_03060Imported, ERS139211_04742Imported, ERS150873_03851Imported, PGD_01899Imported, SK85_01554Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000036012 Componenti: Unassembled WGS sequence
  • UP000044893 Componenti: Unassembled WGS sequence
  • UP000051850 Componenti: Unassembled WGS sequence
  • UP000193530 Componenti: Unassembled WGS sequence
  • UP000186204 Componenti: Unassembled WGS sequence
  • UP000196282 Componenti: Chromosome
  • UP000188855 Componenti: Unassembled WGS sequence
  • UP000050556 Componenti: Unassembled WGS sequence
  • UP000196822 Componenti: Unassembled WGS sequence
  • UP000188724 Componenti: Unassembled WGS sequence
  • UP000070045 Componenti: Unassembled WGS sequence
  • UP000095183 Componenti: Unassembled WGS sequence
  • UP000077380 Componenti: Unassembled WGS sequence
  • UP000194199 Componenti: Chromosome
  • UP000041959 Componenti: Unassembled WGS sequence
  • UP000195107 Componenti: Unassembled WGS sequence
  • UP000042305 Componenti: Unassembled WGS sequence
  • UP000040934 Componenti: Unassembled WGS sequence
  • UP000185422 Componenti: Chromosome

Subcellular locationi

W8TF60:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 31Q_MOTIFInterPro annotationAdd BLAST29
Domaini34 – 205Helicase ATP-bindingInterPro annotationAdd BLAST172
Domaini230 – 376Helicase C-terminalInterPro annotationAdd BLAST147

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni383 – 457Involved in 23S rRNA bindingUniRule annotationAdd BLAST75

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi3 – 31Q motifPROSITE-ProRule annotationAdd BLAST29

Domaini

Contains an N-terminal domain that binds non-specifically to RNA and a C-terminal domain that binds specifically and tightly to hairpin 92 of 23S rRNA.UniRule annotation

Sequence similaritiesi

Belongs to the DEAD box helicase family. DbpA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1J. Bacteria.
COG0513. LUCA.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
HAMAPiMF_00965. DEAD_helicase_DbpA. 1 hit.
InterProiView protein in InterPro
IPR005580. DbpA/CsdA_RNA-bd_dom.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR028619. DEAD_helicase_DbpA.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
PfamiView protein in Pfam
PF03880. DbpA. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.

Sequencei

Sequence statusi: Complete.

W8TF60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAFSTLNVL PPAQLTNLNE LGYLTMTPVQ AAALPAILAG KDVRVQAKTG
60 70 80 90 100
SGKTAAFGLG LLQQIDASLF QTQALVLCPT RELADQVAGE LRRLARFLPN
110 120 130 140 150
TKILTLCGGQ PFGMQRDSLQ HAPHIIVATP GRLLDHLQKG TVSLDALNTL
160 170 180 190 200
VMDEADRMLD MGFSDAIDDV IRFAPASRQT LLFSATWPEA IAAISGRVQR
210 220 230 240 250
DPLAIEIDST DALPPIEQQF YETSSKGKIP LLQRLLSLHQ PSSCVVFCNT
260 270 280 290 300
KKDCQAVCDA LNEVGQSALS LHGDLEQRDR DQTLVRFANG SARVLVATDV
310 320 330 340 350
AARGLDIKSL ELVVNFELAW DPEVHVHRIG RTARAGNSGL AISFCAPEEA
360 370 380 390 400
QRANIISDML QIKLNWQTPP ANSSIATLEA EMATLCIDGG KKAKMRPGDV
410 420 430 440 450
LGALTGDIGL DGADIGKIAV HPAHVYVAVR QAVAHKAWKQ LQGGKIKGKT

CRVRLLK
Length:457
Mass (Da):49,188
Last modified:May 14, 2014 - v1
Checksum:iD9198B1FABA4D38A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017631 Genomic DNA. Translation: APT02631.1.
CP021175 Genomic DNA. Translation: ARR35394.1.
CP021683 Genomic DNA. Translation: ARX14375.1.
HG976952 Genomic DNA. Translation: CDU38818.1.
CYAQ01000014 Genomic DNA. Translation: CTS53197.1.
CYCX01000023 Genomic DNA. Translation: CTW31318.1.
CYDH01000098 Genomic DNA. Translation: CTW91657.1.
CYFX01000032 Genomic DNA. Translation: CTZ69743.1.
LEUM01000011 Genomic DNA. Translation: KLX98438.1.
LDYI01000028 Genomic DNA. Translation: KPO17982.1.
LIVE01000008 Genomic DNA. Translation: KQJ17342.1.
LOOZ01000023 Genomic DNA. Translation: KXR89260.1.
LCVH01000027 Genomic DNA. Translation: OAC44419.1.
LZEH01000112 Genomic DNA. Translation: OEI65468.1.
MSEK01000093 Genomic DNA. Translation: OLR86679.1.
MTKH01000082 Genomic DNA. Translation: ONG29106.1.
MPAF01000053 Genomic DNA. Translation: OOK24991.1.
NAFT01000042 Genomic DNA. Translation: ORT05220.1.
MUAC01000014 Genomic DNA. Translation: OUK53848.1.
LYBG01001170 Genomic DNA. Translation: OWD57962.1.
RefSeqiWP_000123737.1. NZ_NIZE01000094.1.

Genome annotation databases

EnsemblBacteriaiCDU38818; CDU38818; PGD_01899.
CTS53197; CTS53197; ERS085365_01924.
CTW31318; CTW31318; ERS085416_03060.
CTW91657; CTW91657; ERS139211_04742.
CTZ69743; CTZ69743; ERS150873_03851.
KLX98438; KLX98438; SK85_01554.
KPO17982; KPO17982; ACU57_03180.
KQJ17342; KQJ17342; AM266_06865.
KXQ42461; KXQ42461; AUQ01_02030.
OAC44419; OAC44419; EC3234A_27c00310.
OCO22260; OCO22260; AN669_0206110.
ODH29935; ODH29935; A6803_12245.
OEI65468; OEI65468; A9R57_00760.
PATRICifig|562.10472.peg.1123.

Similar proteinsi

Entry informationi

Entry nameiW8TF60_ECOLX
AccessioniPrimary (citable) accession number: W8TF60
Entry historyiIntegrated into UniProtKB/TrEMBL: May 14, 2014
Last sequence update: May 14, 2014
Last modified: October 25, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported