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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Chlamydia avium 10DC88
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotationSAAS annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9MagnesiumUniRule annotation1
Metal bindingi70MagnesiumUniRule annotation1
Metal bindingi145MagnesiumUniRule annotation1
Metal bindingi148MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, NucleaseUniRule annotationSAAS annotation
Biological processDNA damage, DNA recombinationUniRule annotationSAAS annotation, DNA repairUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvCUniRule annotationSAAS annotation (EC:3.1.22.4UniRule annotationSAAS annotation)
Alternative name(s):
Holliday junction nuclease RuvCUniRule annotation
Holliday junction resolvase RuvCUniRule annotation
Gene namesi
Name:ruvCUniRule annotationImported
ORF Names:M832_09210Imported
OrganismiChlamydia avium 10DC88Imported
Taxonomic identifieri1229831 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000019433 Componenti: Chromosome Chlamydia_sp_10DC88

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01159.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00034. RuvC. 1 hit.
InterProiView protein in InterPro
IPR012337. RNaseH-like_sf.
IPR036397. RNaseH_sf.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
PANTHERiPTHR30194. PTHR30194. 1 hit.
PfamiView protein in Pfam
PF02075. RuvC. 1 hit.
PRINTSiPR00696. RSOLVASERUVC.
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00228. ruvC. 1 hit.
PROSITEiView protein in PROSITE
PS01321. RUVC. 1 hit.

Sequencei

Sequence statusi: Complete.

W8JSF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQLIMGIDP GTLASGYAVI VKEKRHQIRA HSYGVIRLSQ KQTLSQRYEK
60 70 80 90 100
LFSTISEIVD TVRPDVVVLE TQYVHKNPQS TIKLGMARGV LLLAAALRKI
110 120 130 140 150
PIFEYAPNVA KRAVIGKGNA SKYQIQLMVS KMLHIPNILQ PDCEDIADAF
160
ALAICHAHTS SYS
Length:163
Mass (Da):18,101
Last modified:May 14, 2014 - v1
Checksum:i657309C59C4CC7E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP006571 Genomic DNA. Translation: AHK63768.1.
RefSeqiWP_038501184.1. NZ_CP006571.1.

Genome annotation databases

EnsemblBacteriaiAHK63768; AHK63768; M832_09210.
KEGGicav:M832_09210.
PATRICifig|1229831.3.peg.921.

Similar proteinsi

Entry informationi

Entry nameiW8JSF2_9CHLA
AccessioniPrimary (citable) accession number: W8JSF2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 14, 2014
Last sequence update: May 14, 2014
Last modified: October 25, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported