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Protein

Glutamate 5-kinase

Gene

proB

Organism
Rhizobium favelukesii
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotationSAAS annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei22ATPUniRule annotation1
Binding sitei62SubstrateUniRule annotation1
Binding sitei149SubstrateUniRule annotation1
Binding sitei161Substrate; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi181 – 182ATPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
Biological processAmino-acid biosynthesis, Proline biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00098; UER00359

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
Alternative name(s):
Gamma-glutamyl kinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:proBUniRule annotationImported
ORF Names:LPU83_4131Imported
OrganismiRhizobium favelukesiiImported
Taxonomic identifieri348824 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000019443 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini287 – 364PUAInterPro annotationAdd BLAST78

Sequence similaritiesi

Belongs to the glutamate 5-kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK00931

Family and domain databases

Gene3Di2.30.130.10, 1 hit
3.40.1160.10, 1 hit
HAMAPiMF_00456 ProB, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR001048 Asp/Glu/Uridylate_kinase
IPR001057 Glu/AcGlu_kinase
IPR011529 Glu_5kinase
IPR005715 Glu_5kinase/COase_Synthase
IPR019797 Glutamate_5-kinase_CS
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PF01472 PUA, 1 hit
PIRSFiPIRSF000729 GK, 1 hit
PRINTSiPR00474 GLU5KINASE
SMARTiView protein in SMART
SM00359 PUA, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR01027 proB, 1 hit
PROSITEiView protein in PROSITE
PS00902 GLUTAMATE_5_KINASE, 1 hit
PS50890 PUA, 1 hit

Sequencei

Sequence statusi: Complete.

W6RZR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKARRMTTR KSLQRYRRVV IKIGSALLVD RKTGLKKAWL DAMCRDIAAL
60 70 80 90 100
KAKGVDILVV SSGAIALGRS VLDLPSGALK LEESQASAAV GQIALARAWS
110 120 130 140 150
ESLSRDEIVA GQILLTLGDT EERRRYLNAR ATINQLLKIG AVPIINENDT
160 170 180 190 200
VATSEIRYGD NDRLAARVAT MTGADLLILL SDIDGLYTAP PHLDPQAEFL
210 220 230 240 250
ATIAEITPEI EAMAGGAASE LSRGGMRTKI DAGKIATTAG CAMIIASGKT
260 270 280 290 300
DSPLSAIESG ARSSWFAPSG TPVTARKTWI AGQLQPAGEL HVDEGAVAAL
310 320 330 340 350
GAGKSLLPAG VRKVVGLFSR GDTVAIVGPH GREIARGLVG YDAEEARQIT
360 370 380 390
GRKSAEIEAI LGYAGRAAMI HRDDMVMTSQ IKSKSERQKK DASYA
Length:395
Mass (Da):41,781
Last modified:April 16, 2014 - v1
Checksum:iE206343387558CA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HG916852 Genomic DNA Translation: CDM59766.1

Genome annotation databases

EnsemblBacteriaiCDM59766; CDM59766; LPU83_4131
KEGGirhl:LPU83_4131
PATRICifig|348824.6.peg.4426

Similar proteinsi

Entry informationi

Entry nameiW6RZR7_9RHIZ
AccessioniPrimary (citable) accession number: W6RZR7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: May 23, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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