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Protein

Succinate--CoA ligase [ADP-forming] subunit beta

Gene

sucC

Organism
Corynebacterium falsenii DSM 44353
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.UniRule annotationSAAS annotation

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes succinate from succinyl-CoA (ligase route).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate--CoA ligase [ADP-forming] subunit alpha (sucD), Succinate--CoA ligase [ADP-forming] subunit beta (sucC)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinate from succinyl-CoA (ligase route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPUniRule annotation1
Binding sitei94ATP; via amide nitrogenUniRule annotation1
Binding sitei99ATPUniRule annotation1
Metal bindingi191MagnesiumUniRule annotation1
Metal bindingi205MagnesiumUniRule annotation1
Binding sitei256Substrate; shared with subunit alphaUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi52 – 54ATPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotation
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER00999.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate--CoA ligase [ADP-forming] subunit betaUniRule annotation (EC:6.2.1.5UniRule annotation)
Alternative name(s):
Succinyl-CoA synthetase subunit betaUniRule annotation
Short name:
SCS-betaUniRule annotation
Gene namesi
Name:sucCUniRule annotation
ORF Names:CFAL_10115Imported
OrganismiCorynebacterium falsenii DSM 44353Imported
Taxonomic identifieri1451189 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000019232 Componenti: Chromosome

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 241ATP-graspInterPro annotationAdd BLAST233

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni319 – 321Substrate binding; shared with subunit alphaUniRule annotation3

Sequence similaritiesi

Belongs to the succinate/malate CoA ligase beta subunit family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01903.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.40.50.261. 1 hit.
HAMAPiMF_00558. Succ_CoA_beta. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013650. ATP-grasp_succ-CoA_synth-type.
IPR013815. ATP_grasp_subdomain_1.
IPR005811. CoA_ligase.
IPR017866. Succ-CoA_synthase_bsu_CS.
IPR005809. Succ_CoA_synthase_bsu.
IPR016102. Succinyl-CoA_synth-like.
PANTHERiPTHR11815. PTHR11815. 1 hit.
PfamiView protein in Pfam
PF08442. ATP-grasp_2. 1 hit.
PF00549. Ligase_CoA. 1 hit.
PIRSFiPIRSF001554. SucCS_beta. 1 hit.
SUPFAMiSSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01016. sucCoAbeta. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS01217. SUCCINYL_COA_LIG_3. 1 hit.

Sequencei

Sequence statusi: Complete.

W5WRQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLYEYQARD LFDKHKVPVL KGVVATSPTQ AEQAASTLGG TVVVKAQVKV
60 70 80 90 100
GGRGKAGGVK LAHSPQEAAD AADAILGLNI KGHVVRKVMV AEGADIAEEY
110 120 130 140 150
YFSILLDRTK RRYMAMLSKE GGVEIEQLAK ERPEALVRRN FSPLDGMTDT
160 170 180 190 200
LAREMAQEAG FDDEDVKKLV PVFKKLYDVY TSEDATLVEV NPLVKTASGE
210 220 230 240 250
ILALDGKVSL DDNARFRHPE HSELEDHSAV NPLELKAQKM GLNYVKLDGS
260 270 280 290 300
VGIIGNGAGL VMSTLDVVAY AGEDLPGQPK PANFLDIGGG ANAEVMANGL
310 320 330 340 350
EVILGDDQVK SVFVNVFGGI TACDEVAKGI VQAYRILEAD GITPKPLVVR
360 370 380 390
LDGNNAEKGR QILDEANVPG LQREDTMDSA ARAAAELAAD NN
Length:392
Mass (Da):41,896
Last modified:April 16, 2014 - v1
Checksum:iE269220DE905A903
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP007156 Genomic DNA. Translation: AHI03889.1.
RefSeqiWP_025403569.1. NZ_CP007156.1.

Genome annotation databases

EnsemblBacteriaiAHI03889; AHI03889; CFAL_10115.
KEGGicfn:CFAL_10115.
PATRICifig|1451189.3.peg.1980.

Similar proteinsi

Entry informationi

Entry nameiW5WRQ8_9CORY
AccessioniPrimary (citable) accession number: W5WRQ8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: September 27, 2017
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported