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Protein

Mitochondrial brown fat uncoupling protein 1

Gene

UCP1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:26038550). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity).By similarity1 Publication

Enzyme regulationi

Has no constitutive proton transporter activity and has to be activated by long-chain fatty acids/LCFAs. Inhibited by purine nucleotides. Both purine nucleotides and LCFAs bind the cytosolic side of the transporter and directly compete to activate or inhibit it (PubMed:26038550). Activated by noradrenaline and reactive oxygen species (By similarity).By similarity1 Publication

GO - Molecular functioni

  • cardiolipin binding Source: UniProtKB
  • GDP binding Source: UniProtKB
  • long-chain fatty acid binding Source: UniProtKB
  • oxidative phosphorylation uncoupler activity Source: UniProtKB
  • transmembrane transporter activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial brown fat uncoupling protein 1Curated
Short name:
UCP 1Curated
Alternative name(s):
Solute carrier family 25 member 7By similarity
ThermogeninBy similarity
Gene namesi
Name:UCP11 Publication
Synonyms:Slc25a7By similarity
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 17

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10Mitochondrial intermembraneBy similarity10
Transmembranei11 – 32Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini33 – 73Mitochondrial matrixBy similarityAdd BLAST41
Transmembranei74 – 96Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini97 – 114Mitochondrial intermembraneBy similarityAdd BLAST18
Transmembranei115 – 131Helical; Name=3Sequence analysisAdd BLAST17
Topological domaini132 – 176Mitochondrial matrixBy similarityAdd BLAST45
Transmembranei177 – 193Helical; Name=4Sequence analysisAdd BLAST17
Topological domaini194 – 210Mitochondrial intermembraneBy similarityAdd BLAST17
Transmembranei211 – 230Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini231 – 264Mitochondrial matrixBy similarityAdd BLAST34
Transmembranei265 – 287Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini288 – 305Mitochondrial intermembraneBy similarityAdd BLAST18

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004382461 – 305Mitochondrial brown fat uncoupling protein 1Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei252Cysteine sulfenic acid (-SOH)By similarity1

Post-translational modificationi

May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects.By similarity
May undergo ubiquitin-mediated proteasomal degradation.By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Most probably functions as a monomer (PubMed:26038550). Binds one purine nucleotide per monomer (PubMed:26038550). However, has also been suggested to function as a homodimer or a homotetramer (By similarity). Tightly associates with cardiolipin in the mitochondrion inner membrane; may stabilize and regulate its activity (PubMed:26038550).By similarity1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 102Solcar 1PROSITE-ProRule annotationAdd BLAST92
Repeati109 – 199Solcar 2PROSITE-ProRule annotationAdd BLAST91
Repeati208 – 293Solcar 3PROSITE-ProRule annotationAdd BLAST86

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119170.
OMAiRYTGTYN.
OrthoDBiEOG091G0BQ7.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002030. Mit_uncoupling_UCP-like.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

W5PSH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGHAATDVP PTMAVKIFSA GVAACVADII TFPLDTAKVR LQIQGECLTS
60 70 80 90 100
SAFRYKGVLG TIITLAKTEG PVKLYSGLPA GLQRQISFAS LRIGLYDTVQ
110 120 130 140 150
EFFTTGKEAS LGSKISAGLT TGGVAVFIGQ PTEVVKVRLQ AQSHLHGPKP
160 170 180 190 200
RYTGTYNAYR IIATTEGLTG LWKGTTPNLT RNVIINCTEL VTYDLMKEAL
210 220 230 240 250
VKNKLLADDV PCHFVSAVVA GFCTTVLSSP VDVVKTRFVN SSPGQYTSVP
260 270 280 290 300
NCAMMMLTRE GPSAFFKGFV PSFLRLGSWN IIMFVCFEQL KRELMKSRQA

MDCAT
Length:305
Mass (Da):32,952
Last modified:April 16, 2014 - v1
Checksum:i3D4BE09BF08C1E43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMGL01037664 Genomic DNA. No translation available.
UniGeneiOar.1067.

Genome annotation databases

EnsembliENSOART00000013603; ENSOARP00000013406; ENSOARG00000012510.

Similar proteinsi

Entry informationi

Entry nameiUCP1_SHEEP
AccessioniPrimary (citable) accession number: W5PSH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: April 16, 2014
Last modified: August 30, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families