Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene
N/A
Organism
Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
OrganismiAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)Imported
Taxonomic identifieri7994 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCharaciformesCharacoideiCharacidaeCharacidae incertae sedisAstyanax cladeAstyanax
Proteomesi
  • UP000018467 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 455FAD_binding_2InterPro annotationAdd BLAST395
Domaini510 – 662Succ_DH_flav_CInterPro annotationAdd BLAST153

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00910000144277
KOiK00234
OMAiGDSPWEH
OrthoDBiEOG091G041Z

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

W5L342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAALAAYRV LGKRVLSYKT VPAVFPEGIR KLHFSIHGKR GEAKISDAIS
60 70 80 90 100
TQYPVVDHEF DAVVVGAGGA GLRAAFGLSE AGFNTACVTK LFPTRSHTVA
110 120 130 140 150
AQGGINAALG NMEEDDWRWH FYDTVKGSDW LGDQDAIHYM TEQAPAAVVE
160 170 180 190 200
LENFGMPFSR TEDGKIYQRA FGGQSLKYGK GGQAHRCCCV ADRTGHSLLH
210 220 230 240 250
TLYGRSLRYD TSYFVEYFAL DLLMEDGECK GVIALCMEDG SIHRIRAKNT
260 270 280 290 300
VIATGGYGRT YFSCTSAHTS TGDGNAMVTR AGLPCQDLEF VQFHPTGIYG
310 320 330 340 350
AGCLITEGCR GEGGILINSE GERFMERYAP NAKDLASRDV VSRSMTIEIR
360 370 380 390 400
EGRGVGPEKD HVYLQLHHLP PQQLATRLPG ISETAMIFAG VDVTKEPIPV
410 420 430 440 450
LPTVHYNMGG IPTNYKGQAI TYKDGKDQVV PGLYACGEAG CASVHGANRL
460 470 480 490 500
GANSLLDLVV FGRACALTIA ENDKPGEKLS PLKPNAGEES VANLDKIRFA
510 520 530 540 550
KGSMRTSEIR LNMQKTMQAH AAVFRTGDVL KEGCVKMDAI YQTLDDVKTF
560 570 580 590 600
DRGIVWNTDL VETLELQNLM LNAVQTINAA EARKESRGAH AREDFKERVD
610 620 630 640 650
EYDYSKPLQG QEKKPFEQHW RKHTLSYVDP KTGKVTLEYR PVIDDSLNNE
660
DCAAIPPAIR SY
Length:662
Mass (Da):72,571
Last modified:April 16, 2014 - v1
Checksum:i8717084D177F30D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
APWO01098178 Genomic DNA No translation available.
APWO01098179 Genomic DNA No translation available.
RefSeqiXP_007253128.1, XM_007253066.2

Genome annotation databases

EnsembliENSAMXT00000014254; ENSAMXP00000014254; ENSAMXG00000013857
GeneIDi103022581
KEGGiamex:103022581

Similar proteinsi

Entry informationi

Entry nameiW5L342_ASTMX
AccessioniPrimary (citable) accession number: W5L342
Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: March 28, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health