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Protein

Xanthine phosphoribosyltransferase

Gene

gpt

Organism
Roseivivax atlanticus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts on guanine, xanthine and to a lesser extent hypoxanthine.UniRule annotationSAAS annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: XMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from xanthine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Xanthine phosphoribosyltransferase (gpt)
This subpathway is part of the pathway XMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from xanthine, the pathway XMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi102MagnesiumUniRule annotation1
Binding sitei105XanthineUniRule annotation1
Binding sitei148Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processPurine salvageUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00602; UER00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
Alternative name(s):
Xanthine-guanine phosphoribosyltransferaseUniRule annotation
Short name:
XGPRTUniRule annotation
Gene namesi
Name:gptUniRule annotation
ORF Names:ATO8_00135Imported
OrganismiRoseivivax atlanticusImported
Taxonomic identifieri1317118 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseivivax
Proteomesi
  • UP000019063 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliW4HQI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 158PribosyltranInterPro annotationAdd BLAST146

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 475-phosphoribose 1-diphosphate bindingUniRule annotation2
Regioni105 – 1095-phosphoribose 1-diphosphate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.UniRule annotationSAAS annotation

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
HAMAPiMF_01903. XGPRT. 1 hit.
InterProiView protein in InterPro
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023747. Xanthine_Guanine_PRibTrfase.
PANTHERiPTHR39563. PTHR39563. 1 hit.
PfamiView protein in Pfam
PF00156. Pribosyltran. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

W4HQI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRLPHEKGF HVSWDQLHRD ARALAWRLQG HGPADGGWKA VVAITRGGMA
60 70 80 90 100
PAMIVSRELD IRTVDTISVK SYNHQTQAEP RIIKSPDAEV VGDGTGILIV
110 120 130 140 150
DDLVDTGKTL EVVRAAMPNA HVATVYAKPQ GKPQVDTFVT EVSQDTWIFF
160
PWDMALQYVK PYHGADD
Length:167
Mass (Da):18,484
Last modified:March 19, 2014 - v1
Checksum:iB5D9CA94454A163B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQQW01000001 Genomic DNA. Translation: ETW14270.1.
RefSeqiWP_043841061.1. NZ_AQQW01000001.1.

Genome annotation databases

EnsemblBacteriaiETW14270; ETW14270; ATO8_00135.
PATRICifig|1317118.6.peg.26.

Similar proteinsi

Entry informationi

Entry nameiW4HQI6_9RHOB
AccessioniPrimary (citable) accession number: W4HQI6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: December 20, 2017
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported