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Protein

V-type proton ATPase subunit a

Gene

NECAME_15715

Organism
Necator americanus (Human hookworm)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
Gene namesi
ORF Names:NECAME_15715Imported
OrganismiNecator americanus (Human hookworm)Imported
Taxonomic identifieri51031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaStrongylidaAncylostomatoideaAncylostomatidaeBunostominaeNecator
Proteomesi
  • UP000053676 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei236 – 257HelicalUniRule annotationAdd BLAST22
Transmembranei355 – 384HelicalUniRule annotationAdd BLAST30

Keywords - Cellular componenti

Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

KOiK02154.

Family and domain databases

InterProiView protein in InterPro
IPR002490. V-ATPase_116kDa_su.
PANTHERiPTHR11629. PTHR11629. 4 hits.
PfamiView protein in Pfam
PF01496. V_ATPase_I. 3 hits.

Sequencei

Sequence statusi: Complete.

W2SIB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSQISNFAG VGVKLAKLLF VEVYKVSFLL QQDTFTKSIT SGGHISGQND
60 70 80 90 100
VPLTPLLNDE KGENAWFVAG VIPLDKKNTF ERVLWRACRR TAFVRISDIT
110 120 130 140 150
LTLEDPVTLA PIMKCVFIVF FKGESLKLII DKKASGCDVS PILNEMARQT
160 170 180 190 200
APPTFHRTNK FTSVFQSIVD SYGVASYREI NPGSYCAPSL LIGLINMFML
210 220 230 240 250
KERPVGYMLE NNSTAHHPTC YLNQWYPEQA FVEKCLIFTA LGCIPVMLLG
260 270 280 290 300
RPLAAYLDQK KMAGRRKFLN GILADDSEHL IAIDRYLHEH SLADAFVNQA
310 320 330 340 350
IHTIEFVLGC VSHTASYLRL WALSLAHAQL SEVLWHMVLI PGISSEGNIL
360 370 380 390 400
TTSAATYVVF FFFAIMSLSI LVMMEGLSAF LHALRLHWVE FQSKFYQGAG
410 420 430
HPFRPYSLQE CLETAQHLSE VTEDHTQCSE VTDEL
Length:435
Mass (Da):48,834
Last modified:March 19, 2014 - v1
Checksum:i1B4B33A65DC12EDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KI669228 Genomic DNA. Translation: ETN68626.1.
RefSeqiXP_013290853.1. XM_013435399.1.

Genome annotation databases

GeneIDi25355741.
KEGGinai:NECAME_15715.

Entry informationi

Entry nameiW2SIB7_NECAM
AccessioniPrimary (citable) accession number: W2SIB7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: October 25, 2017
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported