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Protein

Pantothenate synthetase

Gene

panC

Organism
Klebsiella pneumoniae IS39
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotationSAAS annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton donorUniRule annotation1
Binding sitei61Beta-alanineUniRule annotation1
Binding sitei61PantoateUniRule annotation1
Binding sitei155PantoateUniRule annotation1
Binding sitei178ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37ATPUniRule annotation8
Nucleotide bindingi149 – 152ATPUniRule annotation4
Nucleotide bindingi186 – 189ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processPantothenate biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
OrganismiKlebsiella pneumoniae IS39Imported
Taxonomic identifieri1432561 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000019190 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliW1HSW8.
SMRiW1HSW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC. 1 hit.
InterProiView protein in InterPro
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiView protein in Pfam
PF02569. Pantoate_ligase. 1 hit.
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

W1HSW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIIESVLLL RQHIRRLRQE GKRIALVPTM GNLHDGHMKL VDEAKASADV
60 70 80 90 100
VVVSIFVNPM QFDRVDDLAR YPRTLQDDCE KLNKRHVDFV FAPTPAEVYP
110 120 130 140 150
QGTEGQTYVD VPGLSTMLEG ASRPGHFRGV STIVSKLFNL VQPDVACFGE
160 170 180 190 200
KDFQQLALIR KMVADMGYDI EIIGVPIVRA KDGLALSSRN GYLTADQRKI
210 220 230 240 250
APGLYKVLSA VAEKLAAGDR QLDEIIAIAE QELNEKGFRA DDIQIRDADT
260 270 280
LLELTDASQR AVILMAAWLG QARLIDNRIV TLAQ
Length:284
Mass (Da):31,532
Last modified:March 19, 2014 - v1
Checksum:i0A41C231D4B72F0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CBWU010000438 Genomic DNA. Translation: CDL62010.1.

Genome annotation databases

EnsemblBacteriaiCDL62010; CDL62010; CDL62010.

Similar proteinsi

Entry informationi

Entry nameiW1HSW8_KLEPN
AccessioniPrimary (citable) accession number: W1HSW8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: October 25, 2017
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported