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Protein
Submitted name:

Epididymis secretory sperm binding protein Li 67p

Gene

HEL-S-67p

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. glyoxalase (glycolic acid-forming) activity Source: Ensembl
  2. glyoxalase III activity Source: Ensembl
  3. peroxiredoxin activity Source: Ensembl

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. cellular response to glyoxal Source: Ensembl
  3. cellular response to hydrogen peroxide Source: Ensembl
  4. dopamine uptake involved in synaptic transmission Source: Ensembl
  5. enzyme active site formation via L-cysteine sulfinic acid Source: Ensembl
  6. hydrogen peroxide metabolic process Source: Ensembl
  7. membrane depolarization Source: Ensembl
  8. membrane hyperpolarization Source: Ensembl
  9. methylglyoxal catabolic process to D-lactate Source: Ensembl
  10. mitochondrion organization Source: Ensembl
  11. negative regulation of apoptotic process Source: Ensembl
  12. negative regulation of hydrogen peroxide-induced neuron death Source: Ensembl
  13. negative regulation of protein catabolic process Source: Ensembl
  14. negative regulation of protein ubiquitination Source: Ensembl
  15. positive regulation of mitochondrial electron transport, NADH to ubiquinone Source: Ensembl
  16. positive regulation of oxidative phosphorylation uncoupler activity Source: Ensembl
  17. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  18. protein stabilization Source: Ensembl
  19. regulation of inflammatory response Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Epididymis secretory sperm binding protein Li 67pImported
Gene namesi
Name:HEL-S-67pImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell body Source: Ensembl
  2. cytosol Source: Ensembl
  3. mitochondrial intermembrane space Source: Ensembl
  4. mitochondrial matrix Source: Ensembl
  5. neuron projection Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiV9HWC2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliV9HWC2.
SMRiV9HWC2. Positions 3-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000001231.
KOiK05687.
OMAiMAGDHYK.
PhylomeDBiV9HWC2.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR006287. DJ1.
IPR002818. ThiJ/PfpI.
[Graphical view]
PfamiPF01965. DJ-1_PfpI. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01383. not_thiJ. 1 hit.

Sequencei

Sequence statusi: Complete.

V9HWC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKRALVIL AKGAEEMETV IPVDVMRRAG IKVTVAGLAG KDPVQCSRDV
60 70 80 90 100
VICPDASLED AKKEGPYDVV VLPGGNLGAQ NLSESAAVKE ILKEQENRKG
110 120 130 140 150
LIAAICAGPT ALLAHEIGFG SKVTTHPLAK DKMMNGGHYT YSENRVEKDG
160 170 180
LILTSRGPGT SFEFALAIVE ALNGKEVAAQ VKAPLVLKD
Length:189
Mass (Da):19,891
Last modified:March 19, 2014 - v1
Checksum:i4B21661B3A76BC67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU794641 mRNA. Translation: ACJ13695.1.
RefSeqiNP_001116849.1. NM_001123377.1.
NP_009193.2. NM_007262.4.
XP_005263481.1. XM_005263424.2.
UniGeneiHs.419640.

Genome annotation databases

GeneIDi11315.
KEGGihsa:11315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU794641 mRNA. Translation: ACJ13695.1.
RefSeqiNP_001116849.1. NM_001123377.1.
NP_009193.2. NM_007262.4.
XP_005263481.1. XM_005263424.2.
UniGeneiHs.419640.

3D structure databases

ProteinModelPortaliV9HWC2.
SMRiV9HWC2. Positions 3-188.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11315.
KEGGihsa:11315.

Organism-specific databases

CTDi11315.

Phylogenomic databases

GeneTreeiENSGT00390000001231.
KOiK05687.
OMAiMAGDHYK.
PhylomeDBiV9HWC2.

Miscellaneous databases

ChiTaRSiPARK7. human.
GenomeRNAii11315.

Gene expression databases

ExpressionAtlasiV9HWC2. baseline and differential.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR006287. DJ1.
IPR002818. ThiJ/PfpI.
[Graphical view]
PfamiPF01965. DJ-1_PfpI. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR01383. not_thiJ. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Li J.Y., Wang H.Y., Liu F.J., Liu J.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiV9HWC2_HUMAN
AccessioniPrimary (citable) accession number: V9HWC2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: April 29, 2015
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.