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Protein
Submitted name:

Epididymis luminal protein 60

Gene

HEL60

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Note: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Epididymis luminal protein 60Imported
Gene namesi
Name:HEL60Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000122729.18.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiV9HWB7.
PaxDbiV9HWB7.

Expressioni

Gene expression databases

BgeeiENSG00000122729.
ExpressionAtlasiV9HWB7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliV9HWB7.
SMRiV9HWB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 564AconitaseInterPro annotationAdd BLAST499
Domaini693 – 818Aconitase_CInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the aconitase/IPM isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0452. Eukaryota.
COG1048. LUCA.
KOiK01681.
OMAiMRIIPPG.
OrthoDBiEOG091G01IX.
PhylomeDBiV9HWB7.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProiView protein in InterPro
IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR006249. Aconitase/IRP2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR036008. Aconitase_4Fe-4S_dom.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR029784. IRE-BP1.
PANTHERiPTHR11670. PTHR11670. 1 hit.
PTHR11670:SF32. PTHR11670:SF32. 1 hit.
PfamiView protein in Pfam
PF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR01341. aconitase_1. 1 hit.
PROSITEiView protein in PROSITE
PS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

V9HWB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPFAHLAE PLDPVQPGKK FFNLNKLEDS RYGRLPFSIR VLLEAAIRNC
60 70 80 90 100
DEFLVKKQDI ENILHWNVTQ HKNIEVPFKP ARVILQDFTG VPAVVDFAAM
110 120 130 140 150
RDAVKKLGGD PEKINPVCPA DLVIDHSIQV DFNRRADSLQ KNQDLEFERN
160 170 180 190 200
RERFEFLKWG SQAFHNMRII PPGSGIIHQV NLEYLARVVF DQDGYYYPDS
210 220 230 240 250
LVGTDSHTTM IDGLGILGWG VGGIEAEAVM LGQPISMVLP QVIGYRLMGK
260 270 280 290 300
PHPLVTSTDI VLTITKHLRQ VGVVGKFVEF FGPGVAQLSI ADRATIANMC
310 320 330 340 350
PEYGATAAFF PVDEVSITYL VQTGRDEEKL KYIKKYLQAV GMFRDFNDPS
360 370 380 390 400
QDPDFTQVVE LDLKTVVPCC SGPKRPQDKV AVSDMKKDFE SCLGAKQGFK
410 420 430 440 450
GFQVAPEHHN DHKTFIYDNT EFTLAHGSVV IAAITSCTNT SNPSVMLGAG
460 470 480 490 500
LLAKKAVDAG LNVMPYIKTS LSPGSGVVTY YLQESGVMPY LSQLGFDVVG
510 520 530 540 550
YGCMTCIGNS GPLPEPVVEA ITQGDLVAVG VLSGNRNFEG RVHPNTRANY
560 570 580 590 600
LASPPLVIAY AIAGTIRIDF EKEPLGVNAK GQQVFLKDIW PTRDEIQAVE
610 620 630 640 650
RQYVIPGMFK EVYQKIETVN ESWNALATPS DKLFFWNSKS TYIKSPPFFE
660 670 680 690 700
NLTLDLQPPK SIVDAYVLLN LGDSVTTDHI SPAGNIARNS PAARYLTNRG
710 720 730 740 750
LTPREFNSYG SRRGNDAVMA RGTFANIRLL NRFLNKQAPQ TIHLPSGEIL
760 770 780 790 800
DVFDAAERYQ QAGLPLIVLA GKEYGAGSSR DWAAKGPFLL GIKAVLAESY
810 820 830 840 850
ERIHRSNLVG MGVIPLEYLP GENADALGLT GQERYTIIIP ENLKPQMKVQ
860 870 880
VKLDTGKTFQ AVMRFDTDVE LTYFLNGGIL NYMIRKMAK
Length:889
Mass (Da):98,399
Last modified:March 19, 2014 - v1
Checksum:iE1A05AF701D46DCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU794627 mRNA. Translation: ACJ13681.1.
RefSeqiNP_001265281.1. NM_001278352.1.
NP_002188.1. NM_002197.2.
XP_005251533.1. XM_005251476.1.
XP_011516190.1. XM_011517888.1.
UniGeneiHs.567229.

Genome annotation databases

GeneIDi48.
KEGGihsa:48.
UCSCiuc003zqw.5. human.

Similar proteinsi

Entry informationi

Entry nameiV9HWB7_HUMAN
AccessioniPrimary (citable) accession number: V9HWB7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: October 25, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.