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Protein

Calponin

Gene

HEL-S-14

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.UniRule annotation

GO - Biological processi

Keywordsi

Molecular functionActin-bindingUniRule annotation, Calmodulin-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
CalponinUniRule annotation
Gene namesi
Name:HEL-S-14Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

MaxQBiV9HWA5.
PaxDbiV9HWA5.

Expressioni

Gene expression databases

ExpressionAtlasiV9HWA5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000252456.

Structurei

3D structure databases

ProteinModelPortaliV9HWA5.
SMRiV9HWA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 131Actin-bindingInterPro annotationAdd BLAST104

Sequence similaritiesi

Belongs to the calponin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
OMAiRQIFEPT.
OrthoDBiEOG091G0LY2.
PhylomeDBiV9HWA5.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiView protein in InterPro
IPR001997. Calponin/LIMCH1.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
PfamiView protein in Pfam
PF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiView protein in SMART
SM00033. CH. 1 hit.
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiView protein in PROSITE
PS01052. CALPONIN_1. 2 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.

Sequencei

Sequence statusi: Complete.

V9HWA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAHFNRGP AYGLSAEVKN KLAQKYDHQR EQELREWIEG VTGRRIGNNF
60 70 80 90 100
MDGLKDGIIL CEFINKLQPG SVKKINESTQ NWHQLENIGN FIKAITKYGV
110 120 130 140 150
KPHDIFEAND LFENTNHTQV QSTLLALASM AKTKGNKVNV GVKYAEKQER
160 170 180 190 200
KFEPGKLREG RNIIGLQMGT NKFASQQGMT AYGTRRHLYD PKLGTDQPLD
210 220 230 240 250
QATISLQMGT NKGASQAGMT APGTKRQIFE PGLGMEHCDT LNVSLQMGSN
260 270 280 290
KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LGEPAHNHHA HNYYNSA
Length:297
Mass (Da):33,170
Last modified:March 19, 2014 - v1
Checksum:iA949573543BC246C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU794601 mRNA. Translation: ACJ13655.1.
RefSeqiNP_001290.2. NM_001299.5.
UniGeneiHs.465929.

Genome annotation databases

GeneIDi1264.
KEGGihsa:1264.
UCSCiuc002msc.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU794601 mRNA. Translation: ACJ13655.1.
RefSeqiNP_001290.2. NM_001299.5.
UniGeneiHs.465929.

3D structure databases

ProteinModelPortaliV9HWA5.
SMRiV9HWA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000252456.

Proteomic databases

MaxQBiV9HWA5.
PaxDbiV9HWA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1264.
KEGGihsa:1264.
UCSCiuc002msc.2. human.

Organism-specific databases

CTDi1264.

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
OMAiRQIFEPT.
OrthoDBiEOG091G0LY2.
PhylomeDBiV9HWA5.

Miscellaneous databases

ChiTaRSiCNN1. human.
GenomeRNAii1264.

Gene expression databases

ExpressionAtlasiV9HWA5. baseline and differential.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiView protein in InterPro
IPR001997. Calponin/LIMCH1.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
PfamiView protein in Pfam
PF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiView protein in SMART
SM00033. CH. 1 hit.
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiView protein in PROSITE
PS01052. CALPONIN_1. 2 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiV9HWA5_HUMAN
AccessioniPrimary (citable) accession number: V9HWA5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: April 12, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.