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Protein
Submitted name:

Betaine-homocysteine methyltransferase, isoform CRA_a

Gene

HEL-S-61p

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the regulation of homocysteine metabolism.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from L-homocysteine (BhmT route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. cDNA, FLJ96222, highly similar to Homo sapiens betaine-homocysteine methyltransferase (BHMT), mRNA, Betaine-homocysteine methyltransferase, isoform CRA_a (HEL-S-61p), cDNA FLJ54604, highly similar to Betaine--homocysteine S-methyltransferase (EC 2.1.1.5), S-methylmethionine--homocysteine S-methyltransferase BHMT2 (BHMT2), Betaine--homocysteine S-methyltransferase 1 (BHMT), cDNA, FLJ96586, highly similar to Homo sapiens betaine-homocysteine methyltransferase 2 (BHMT2), mRNA, Betaine-homocysteine methyltransferase 2, isoform CRA_c (BHMT2)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from L-homocysteine (BhmT route), the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi217 – 2171ZincUniRule annotation
Metal bindingi299 – 2991ZincUniRule annotation
Metal bindingi300 – 3001ZincUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationImported, Transferase

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00051; UER00083.

Names & Taxonomyi

Protein namesi
Submitted name:
Betaine-homocysteine methyltransferase, isoform CRA_aImported
Submitted name:
Epididymis secretory sperm binding protein Li 61pImported
Gene namesi
Name:HEL-S-61pImported
Synonyms:BHMTImported
ORF Names:hCG_2039815Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiV9HWA4.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000274353.

Structurei

3D structure databases

SMRiV9HWA4. Positions 8-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 314304Hcy-bindingInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1579. Eukaryota.
COG0646. LUCA.
KOiK00544.
OMAiAQPLAYH.
OrthoDBiEOG091G09QD.
PhylomeDBiV9HWA4.

Family and domain databases

Gene3Di3.20.20.330. 1 hit.
InterProiIPR017226. Betaine-hCys_S-MeTrfase_BHMT.
IPR003726. HCY_dom.
[Graphical view]
PfamiPF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF037505. Betaine_HMT. 1 hit.
SUPFAMiSSF82282. SSF82282. 1 hit.
PROSITEiPS50970. HCY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

V9HWA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPVGGKKAK KGILERLNAG EIVIGDGGFV FALEKRGYVK AGPWTPEAAV
60 70 80 90 100
EHPEAVRQLH REFLRAGSNV MQTFTFYASE DKLENRGNYV LEKISGQEVN
110 120 130 140 150
EAACDIARQV ADEGDALVAG GVSQTPSYLS CKSETEVKKV FLQQLEVFMK
160 170 180 190 200
KNVDFLIAEY FEHVEEAVWA VETLIASGKP VAATMCIGPE GDLHGVPPGE
210 220 230 240 250
CAVRLVKAGA SIIGVNCHFD PTISLKTVKL MKEGLEAARL KAHLMSQPLA
260 270 280 290 300
YHTPDCNKQG FIDLPEFPFG LEPRVATRWD IQKYAREAYN LGVRYIGGCC
310 320 330 340 350
GFEPYHIRAI AEELAPERGF LPPASEKHGS WGSGLDMHTK PWVRARARKE
360 370 380 390 400
YWENLRIASG RPYNPSMSKP DGWGVTKGTA ELMQQKEATT EQQLKELFEK

QKFKSQ
Length:406
Mass (Da):44,998
Last modified:March 19, 2014 - v1
Checksum:i557855B8CEDD0D54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU794592 mRNA. Translation: ACJ13646.1.
CH471084 Genomic DNA. Translation: EAW95831.1.
RefSeqiNP_001704.2. NM_001713.2.
UniGeneiHs.80756.

Genome annotation databases

GeneIDi635.
KEGGihsa:635.
UCSCiuc003kfu.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU794592 mRNA. Translation: ACJ13646.1.
CH471084 Genomic DNA. Translation: EAW95831.1.
RefSeqiNP_001704.2. NM_001713.2.
UniGeneiHs.80756.

3D structure databases

SMRiV9HWA4. Positions 8-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000274353.

Proteomic databases

MaxQBiV9HWA4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi635.
KEGGihsa:635.
UCSCiuc003kfu.5. human.

Organism-specific databases

CTDi635.

Phylogenomic databases

eggNOGiKOG1579. Eukaryota.
COG0646. LUCA.
KOiK00544.
OMAiAQPLAYH.
OrthoDBiEOG091G09QD.
PhylomeDBiV9HWA4.

Enzyme and pathway databases

UniPathwayiUPA00051; UER00083.

Miscellaneous databases

ChiTaRSiBHMT. human.
GenomeRNAii635.

Family and domain databases

Gene3Di3.20.20.330. 1 hit.
InterProiIPR017226. Betaine-hCys_S-MeTrfase_BHMT.
IPR003726. HCY_dom.
[Graphical view]
PfamiPF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF037505. Betaine_HMT. 1 hit.
SUPFAMiSSF82282. SSF82282. 1 hit.
PROSITEiPS50970. HCY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV9HWA4_HUMAN
AccessioniPrimary (citable) accession number: V9HWA4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: September 7, 2016
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.