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Protein

Glycine N-methyltransferase

Gene

HEL-S-182mP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei22S-adenosyl-L-methionineUniRule annotation1
Binding sitei31S-adenosyl-L-methionineUniRule annotation1
Binding sitei34SubstrateUniRule annotation1
Binding sitei41S-adenosyl-L-methionineUniRule annotation1
Binding sitei65S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei86S-adenosyl-L-methionineUniRule annotation1
Binding sitei139S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei141SubstrateUniRule annotation1
Binding sitei178SubstrateUniRule annotation1
Binding sitei223SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationImported, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine N-methyltransferaseUniRule annotation (EC:2.1.1.20UniRule annotation)
Gene namesi
Name:HEL-S-182mPImported
Synonyms:GNMTImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiV9HW60.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361894.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni117 – 118S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IF1C. Eukaryota.
ENOG410ZWXN. LUCA.
KOiK00552.
OMAiMITLDYT.
OrthoDBiEOG091G0J3Z.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR014369. Gly/Sar_N_MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR16458. PTHR16458. 1 hit.
PIRSFiPIRSF000385. Gly_N-mtase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51600. SAM_GNMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

V9HW60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDSVYRTRS LGVAAEGLPD QYADGEAARV WQLYIGDTRS RTAEYKAWLL
60 70 80 90 100
GLLRQHGCQR VLDVACGTGV DSIMLVEEGF SVTSVDASDK MLKYALKERW
110 120 130 140 150
NRRHEPAFDK WVIEEANWMT LDKDVPQSAE GGFDAVICLG NSFAHLPDCK
160 170 180 190 200
GDQSEHRLAL KNIASMVRAG GLLVIDHRNY DHILSTGCAP PGKNIYYKSD
210 220 230 240 250
LTKDVTTSVL IVNNKAHMVT LDYTVQVPGA GQDGSPGLSK FRLSYYPHCL
260 270 280 290
ASFTELLQAA FGGKCQHSVL GDFKPYKPGQ TYIPCYFIHV LKRTD
Length:295
Mass (Da):32,742
Last modified:March 19, 2014 - v1
Checksum:i34F4546136FD27ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei295Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ224320 mRNA. Translation: ACI46012.1.
KU178603 mRNA. Translation: ALQ34061.1.
RefSeqiNP_061833.1. NM_018960.5.
UniGeneiHs.144914.

Genome annotation databases

GeneIDi27232.
KEGGihsa:27232.
UCSCiuc003otd.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ224320 mRNA. Translation: ACI46012.1.
KU178603 mRNA. Translation: ALQ34061.1.
RefSeqiNP_061833.1. NM_018960.5.
UniGeneiHs.144914.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361894.

Proteomic databases

PaxDbiV9HW60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi27232.
KEGGihsa:27232.
UCSCiuc003otd.4. human.

Organism-specific databases

CTDi27232.

Phylogenomic databases

eggNOGiENOG410IF1C. Eukaryota.
ENOG410ZWXN. LUCA.
KOiK00552.
OMAiMITLDYT.
OrthoDBiEOG091G0J3Z.

Miscellaneous databases

GenomeRNAii27232.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR014369. Gly/Sar_N_MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR16458. PTHR16458. 1 hit.
PIRSFiPIRSF000385. Gly_N-mtase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51600. SAM_GNMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV9HW60_HUMAN
AccessioniPrimary (citable) accession number: V9HW60
Entry historyi
Integrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: November 2, 2016
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.