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Protein
Submitted name:

Alpha-crystallin B chain

Gene

HEL-S-101

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-crystallin B chainImported
Submitted name:
Crystallin, alpha B, isoform CRA_aImported
Submitted name:
Epididymis secretory protein Li 101Imported
Gene namesi
Name:HEL-S-101Imported
Synonyms:CRYABImported
ORF Names:hCG_1730741Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiV9HW27.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000227251.

Structurei

3D structure databases

SMRiV9HW27. Positions 1-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 14983HSP20InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
KOiK09542.
OMAiTITAPMK.
OrthoDBiEOG091G0USC.
PhylomeDBiV9HW27.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR012273. Alpha-crystallin_B.
IPR003090. Alpha-crystallin_N.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PTHR11527:SF37. PTHR11527:SF37. 1 hit.
PfamiPF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view]
PIRSFiPIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

V9HW27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR
60 70 80 90 100
PPSFLRAPSW FDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV
110 120 130 140 150
HGKHEERQDE HGFISREFHR KYRIPADVDP LTITSSLSSD GVLTVNGPRK
160 170
QVSGPERTIP ITREEKPAVT AAPKK
Length:175
Mass (Da):20,159
Last modified:March 19, 2014 - v1
Checksum:iAE08BED46B7849CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ224314 mRNA. Translation: ACI46006.1.
KM220603 mRNA. Translation: AMM63597.1.
KM220604 mRNA. Translation: AMM63598.1.
KM220605 mRNA. Translation: AMM63599.1.
KM220606 mRNA. Translation: AMM63600.1.
CH471065 Genomic DNA. Translation: EAW67163.1.
CH471065 Genomic DNA. Translation: EAW67165.1.
RefSeqiNP_001276736.1. NM_001289807.1.
NP_001276737.1. NM_001289808.1.
NP_001876.1. NM_001885.2.
XP_011540910.1. XM_011542608.1.
UniGeneiHs.53454.
Hs.703770.

Genome annotation databases

GeneIDi1410.
KEGGihsa:1410.
UCSCiuc001pmf.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ224314 mRNA. Translation: ACI46006.1.
KM220603 mRNA. Translation: AMM63597.1.
KM220604 mRNA. Translation: AMM63598.1.
KM220605 mRNA. Translation: AMM63599.1.
KM220606 mRNA. Translation: AMM63600.1.
CH471065 Genomic DNA. Translation: EAW67163.1.
CH471065 Genomic DNA. Translation: EAW67165.1.
RefSeqiNP_001276736.1. NM_001289807.1.
NP_001276737.1. NM_001289808.1.
NP_001876.1. NM_001885.2.
XP_011540910.1. XM_011542608.1.
UniGeneiHs.53454.
Hs.703770.

3D structure databases

SMRiV9HW27. Positions 1-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000227251.

Proteomic databases

MaxQBiV9HW27.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1410.
KEGGihsa:1410.
UCSCiuc001pmf.3. human.

Organism-specific databases

CTDi1410.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
KOiK09542.
OMAiTITAPMK.
OrthoDBiEOG091G0USC.
PhylomeDBiV9HW27.

Miscellaneous databases

ChiTaRSiCRYAB. human.
GenomeRNAii1410.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR012273. Alpha-crystallin_B.
IPR003090. Alpha-crystallin_N.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PTHR11527:SF37. PTHR11527:SF37. 1 hit.
PfamiPF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view]
PIRSFiPIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV9HW27_HUMAN
AccessioniPrimary (citable) accession number: V9HW27
Entry historyi
Integrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: September 7, 2016
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.