UniProtKB - V9HVY3 (V9HVY3_HUMAN)
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Protein
Protein disulfide-isomerase
Gene
HEL-S-269
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Catalyzes the rearrangement of -S-S- bonds in proteins.UniRule annotation
GO - Molecular functioni
- protein disulfide isomerase activity Source: UniProtKB-EC
GO - Biological processi
- cell redox homeostasis Source: InterPro
- positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Keywordsi
Molecular function | IsomeraseUniRule annotationImported |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:HEL-S-269Imported Synonyms:HEL-S-93nImported, PDIA3Imported ORF Names:hCG_38001Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167004.12 |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | UniRule annotationAdd BLAST | 24 | |
ChainiPRO_5014206131 | 25 – 505 | Protein disulfide-isomeraseUniRule annotationAdd BLAST | 481 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 57 ↔ 60 | Redox-activeUniRule annotation | ||
Disulfide bondi | 406 ↔ 409 | Redox-activeUniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationSAAS annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 133 | ThioredoxinInterPro annotationAdd BLAST | 115 | |
Domaini | 343 – 485 | ThioredoxinInterPro annotationAdd BLAST | 143 |
Sequence similaritiesi
Keywords - Domaini
Redox-active centerUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotationPhylogenomic databases
eggNOGi | KOG0190 Eukaryota COG0526 LUCA |
KOi | K08056 |
OMAi | VAIVKMD |
OrthoDBi | EOG091G05J9 |
Family and domain databases
InterProi | View protein in InterPro IPR005788 Disulphide_isomerase IPR005792 Prot_disulphide_isomerase IPR036249 Thioredoxin-like_sf IPR017937 Thioredoxin_CS IPR013766 Thioredoxin_domain |
Pfami | View protein in Pfam PF00085 Thioredoxin, 2 hits |
SUPFAMi | SSF52833 SSF52833, 4 hits |
TIGRFAMsi | TIGR01130 ER_PDI_fam, 1 hit TIGR01126 pdi_dom, 2 hits |
PROSITEi | View protein in PROSITE PS00194 THIOREDOXIN_1, 2 hits PS51352 THIOREDOXIN_2, 2 hits |
i Sequence
Sequence statusi: Complete.
V9HVY3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLRRLALFP GVALLLAAAR LAAASDVLEL TDDNFESRIS DTGSAGLMLV
60 70 80 90 100
EFFAPWCGHC KRLAPEYEAA ATRLKGIVPL AKVDCTANTN TCNKYGVSGY
110 120 130 140 150
PTLKIFRDGE EAGAYDGPRT ADGIVSHLKK QAGPASVPLR TEEEFKKFIS
160 170 180 190 200
DKDASIVGFF DDSFSEAHSE FLKAASNLRD NYRFAHTNVE SLVNEYDDNG
210 220 230 240 250
EGIILFRPSH LTNKFEDKTV AYTEQKMTSG KIKKFIQENI FGICPHMTED
260 270 280 290 300
NKDLIQGKDL LIAYYDVDYE KNAKGSNYWR NRVMMVAKKF LDAGHKLNFA
310 320 330 340 350
VASRKTFSHE LSDFGLESTA GEIPVVAIRT AKGEKFVMQE EFSRDGKALE
360 370 380 390 400
RFLQDYFDGN LKRYLKSEPI PESNDGPVKV VVAENFDEIV NNENKDVLIE
410 420 430 440 450
FYAPWCGHCK NLEPKYKELG EKLSKDPNIV IAKMDATAND VPSPYEVRGF
460 470 480 490 500
PTIYFSPANK KLNPKKYEGG RELSDFISYL QREATNPPVI QEEKPKKKKK
AQEDL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU668338 mRNA Translation: ACF94491.1 FJ224330 mRNA Translation: ACI46022.1 CH471082 Genomic DNA Translation: EAW77236.1 |
RefSeqi | NP_005304.3, NM_005313.4 |
UniGenei | Hs.591095 |
Genome annotation databases
GeneIDi | 2923 |
KEGGi | hsa:2923 |
UCSCi | uc001zsu.4 human |
Similar proteinsi
Entry informationi
Entry namei | V9HVY3_HUMAN | |
Accessioni | V9HVY3Primary (citable) accession number: V9HVY3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 19, 2014 |
Last sequence update: | March 19, 2014 | |
Last modified: | April 25, 2018 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |