HEL-S-269

Functionⁱ

Catalytic activityⁱ

Catalyzes the rearrangement of -S-S- bonds in proteins.UniRule annotation

GO - Molecular functionⁱ

protein disulfide isomerase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell redox homeostasis Source: InterPro
positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	IsomeraseUniRule annotationImported

Molecular function

IsomeraseUniRule annotationImported

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein disulfide-isomeraseUniRule annotation (EC:5.3.4.1UniRule annotation)
Gene namesⁱ	Name:HEL-S-269Imported Synonyms:HEL-S-93nImported, PDIA3Imported ORF Names:hCG_38001Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167004.12

EuPathDBⁱ

HostDB:ENSG00000167004.12

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	UniRule annotationAdd BLAST		24
ChainⁱPRO_5014206131	25 – 505	Protein disulfide-isomeraseUniRule annotationAdd BLAST		481

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	57 ↔ 60	Redox-activeUniRule annotation
Disulfide bondⁱ	406 ↔ 409	Redox-activeUniRule annotation

Keywords - PTMⁱ

Disulfide bondUniRule annotationSAAS annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000167004

Bgeeⁱ

ENSG00000167004

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	19 – 133	ThioredoxinInterPro annotationAdd BLAST		115
Domainⁱ	343 – 485	ThioredoxinInterPro annotationAdd BLAST		143

Sequence similaritiesⁱ

Belongs to the protein disulfide isomerase family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Redox-active centerUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0190 Eukaryota COG0526 LUCA
KEGG Orthology (KO) More...KOⁱ	K08056
OMAⁱ	VAIVKMD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05J9

Family and domain databases

InterProⁱ	View protein in InterPro IPR005788 Disulphide_isomerase IPR005792 Prot_disulphide_isomerase IPR036249 Thioredoxin-like_sf IPR017937 Thioredoxin_CS IPR013766 Thioredoxin_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00085 Thioredoxin, 2 hits
SUPFAMⁱ	SSF52833 SSF52833, 4 hits
TIGRFAMsⁱ	TIGR01130 ER_PDI_fam, 1 hit TIGR01126 pdi_dom, 2 hits
PROSITEⁱ	View protein in PROSITE PS00194 THIOREDOXIN_1, 2 hits PS51352 THIOREDOXIN_2, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

V9HVY3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLRRLALFP GVALLLAAAR LAAASDVLEL TDDNFESRIS DTGSAGLMLV 
        60         70         80         90        100
EFFAPWCGHC KRLAPEYEAA ATRLKGIVPL AKVDCTANTN TCNKYGVSGY 
       110        120        130        140        150
PTLKIFRDGE EAGAYDGPRT ADGIVSHLKK QAGPASVPLR TEEEFKKFIS 
       160        170        180        190        200
DKDASIVGFF DDSFSEAHSE FLKAASNLRD NYRFAHTNVE SLVNEYDDNG 
       210        220        230        240        250
EGIILFRPSH LTNKFEDKTV AYTEQKMTSG KIKKFIQENI FGICPHMTED 
       260        270        280        290        300
NKDLIQGKDL LIAYYDVDYE KNAKGSNYWR NRVMMVAKKF LDAGHKLNFA 
       310        320        330        340        350
VASRKTFSHE LSDFGLESTA GEIPVVAIRT AKGEKFVMQE EFSRDGKALE 
       360        370        380        390        400
RFLQDYFDGN LKRYLKSEPI PESNDGPVKV VVAENFDEIV NNENKDVLIE 
       410        420        430        440        450
FYAPWCGHCK NLEPKYKELG EKLSKDPNIV IAKMDATAND VPSPYEVRGF 
       460        470        480        490        500
PTIYFSPANK KLNPKKYEGG RELSDFISYL QREATNPPVI QEEKPKKKKK 

AQEDL

Length:505

Mass (Da):56,782

Last modified:March 19, 2014 - v1

Checksum:ⁱ529E5B6692D0D7E9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EU668338 mRNA Translation: ACF94491.1 FJ224330 mRNA Translation: ACI46022.1 CH471082 Genomic DNA Translation: EAW77236.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005304.3, NM_005313.4
UniGeneⁱ	Hs.591095

Genome annotation databases

GeneIDⁱ	2923
KEGGⁱ	hsa:2923
UCSC genome browser More...UCSCⁱ	uc001zsu.4 human

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
V9HVY3	P30101 Q5RDG4 G2HFN6 A0A2J8NTU6 UPI000C2102F4 G3SC18 UPI0000DBEC6F	Homo sapiens (Human) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla)	505	UniRef100_P30101	Cluster: Protein disulfide-isomerase A3	8

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
V9HVY3	P30101 Q5RDG4 G2HFN6 A0A2J8NTU6 UPI000C2102F4 G3SC18 UPI0000DBEC6F UPI0002C45977 K9IT02 A0A0H2UHM5 +129	Homo sapiens (Human) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla) Trichechus manatus latirostris (Florida manatee) Desmodus rotundus (Vampire bat) Rattus norvegicus (Rat) Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli) Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur) Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) And more	505	UniRef90_P30101	Cluster: Protein disulfide-isomerase A3	140

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
V9HVY3	P30101 Q5RDG4 G2HFN6 A0A2J8NTU6 UPI000C2102F4 G3SC18 UPI0000DBEC6F UPI0002C45977 K9IT02 A0A0H2UHM5 +160	Homo sapiens (Human) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla) Trichechus manatus latirostris (Florida manatee) Desmodus rotundus (Vampire bat) Rattus norvegicus (Rat) Camelus dromedarius (Dromedary) (Arabian camel) Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur) Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli) And more	505	UniRef50_P30101	Cluster: Protein disulfide-isomerase A3	171

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EU668338 mRNA Translation: ACF94491.1 FJ224330 mRNA Translation: ACI46022.1 CH471082 Genomic DNA Translation: EAW77236.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005304.3, NM_005313.4
UniGeneⁱ	Hs.591095

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	2923
KEGGⁱ	hsa:2923
UCSC genome browser More...UCSCⁱ	uc001zsu.4 human

Organism-specific databases

CTDⁱ	2923
EuPathDBⁱ	HostDB:ENSG00000167004.12

Phylogenomic databases

eggNOGⁱ	KOG0190 Eukaryota COG0526 LUCA
KEGG Orthology (KO) More...KOⁱ	K08056
OMAⁱ	VAIVKMD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05J9

Miscellaneous databases

ChiTaRSⁱ	PDIA3 human
GenomeRNAiⁱ	2923

Gene expression databases

Bgeeⁱ	ENSG00000167004

Bgeeⁱ

ENSG00000167004

Family and domain databases

InterProⁱ	View protein in InterPro IPR005788 Disulphide_isomerase IPR005792 Prot_disulphide_isomerase IPR036249 Thioredoxin-like_sf IPR017937 Thioredoxin_CS IPR013766 Thioredoxin_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00085 Thioredoxin, 2 hits
SUPFAMⁱ	SSF52833 SSF52833, 4 hits
TIGRFAMsⁱ	TIGR01130 ER_PDI_fam, 1 hit TIGR01126 pdi_dom, 2 hits
PROSITEⁱ	View protein in PROSITE PS00194 THIOREDOXIN_1, 2 hits PS51352 THIOREDOXIN_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	V9HVY3_HUMAN
Accessionⁱ	V9HVY3Primary (citable) accession number: V9HVY3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 19, 2014
	Last sequence update:	March 19, 2014
	Last modified:	April 25, 2018
	This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - V9HVY3 (V9HVY3_HUMAN)

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Protein disulfide-isomerase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ