HEL-S-269

Functionⁱ

Catalytic activityⁱ

Catalyzes the rearrangement of -S-S- bonds in proteins.UniRule annotation

GO - Molecular functionⁱ

protein disulfide isomerase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

cell redox homeostasis Source: InterPro
positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	IsomeraseUniRule annotationImported

Molecular function

IsomeraseUniRule annotationImported

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein disulfide-isomeraseUniRule annotation (EC:5.3.4.1UniRule annotation)
Gene namesⁱ	Name:HEL-S-269Imported Synonyms:HEL-S-93nImported, PDIA3Imported ORF Names:hCG_38001Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

GO - Cellular componentⁱ

cell surface Source: Ensembl
endoplasmic reticulum Source: HPA
myelin sheath Source: Ensembl

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	UniRule annotationAdd BLAST		24
ChainⁱPRO_5009999480	25 – 505	Protein disulfide-isomeraseUniRule annotationAdd BLAST		481

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	57 ↔ 60	Redox-activeUniRule annotation
Disulfide bondⁱ	406 ↔ 409	Redox-activeUniRule annotation

Keywords - PTMⁱ

Disulfide bondUniRule annotationSAAS annotation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	V9HVY3.

MaxQBⁱ

V9HVY3.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000167004.
ExpressionAtlasⁱ	V9HVY3. baseline and differential.

Structureⁱ

3D structure databases

SMRⁱ	V9HVY3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	19 – 133	ThioredoxinInterPro annotationAdd BLAST		115
Domainⁱ	343 – 485	ThioredoxinInterPro annotationAdd BLAST		143

Sequence similaritiesⁱ

Belongs to the protein disulfide isomerase family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Redox-active centerUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0190. Eukaryota. COG0526. LUCA.
KEGG Orthology (KO) More...KOⁱ	K08056.
OMAⁱ	VAIVKMD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05J9.

Family and domain databases

InterProⁱ	View protein in InterPro IPR005788. Disulphide_isomerase. IPR005792. Prot_disulphide_isomerase. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00085. Thioredoxin. 2 hits.
SUPFAMⁱ	SSF52833. SSF52833. 4 hits.
TIGRFAMsⁱ	TIGR01130. ER_PDI_fam. 1 hit. TIGR01126. pdi_dom. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00194. THIOREDOXIN_1. 2 hits. PS51352. THIOREDOXIN_2. 2 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

V9HVY3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLRRLALFP GVALLLAAAR LAAASDVLEL TDDNFESRIS DTGSAGLMLV 
        60         70         80         90        100
EFFAPWCGHC KRLAPEYEAA ATRLKGIVPL AKVDCTANTN TCNKYGVSGY 
       110        120        130        140        150
PTLKIFRDGE EAGAYDGPRT ADGIVSHLKK QAGPASVPLR TEEEFKKFIS 
       160        170        180        190        200
DKDASIVGFF DDSFSEAHSE FLKAASNLRD NYRFAHTNVE SLVNEYDDNG 
       210        220        230        240        250
EGIILFRPSH LTNKFEDKTV AYTEQKMTSG KIKKFIQENI FGICPHMTED 
       260        270        280        290        300
NKDLIQGKDL LIAYYDVDYE KNAKGSNYWR NRVMMVAKKF LDAGHKLNFA 
       310        320        330        340        350
VASRKTFSHE LSDFGLESTA GEIPVVAIRT AKGEKFVMQE EFSRDGKALE 
       360        370        380        390        400
RFLQDYFDGN LKRYLKSEPI PESNDGPVKV VVAENFDEIV NNENKDVLIE 
       410        420        430        440        450
FYAPWCGHCK NLEPKYKELG EKLSKDPNIV IAKMDATAND VPSPYEVRGF 
       460        470        480        490        500
PTIYFSPANK KLNPKKYEGG RELSDFISYL QREATNPPVI QEEKPKKKKK 

AQEDL

Length:505

Mass (Da):56,782

Last modified:March 19, 2014 - v1

Checksum:ⁱ529E5B6692D0D7E9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EU668338 mRNA. Translation: ACF94491.1. FJ224330 mRNA. Translation: ACI46022.1. CH471082 Genomic DNA. Translation: EAW77236.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_005304.3. NM_005313.4.
UniGeneⁱ	Hs.591095.

Genome annotation databases

GeneIDⁱ	2923.
KEGGⁱ	hsa:2923.
UCSC genome browser More...UCSCⁱ	uc001zsu.4. human.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
V9HVY3	P30101 Q5RDG4 G2HFN6	Homo sapiens (Human) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee)	505	UniRef100_P30101	Cluster: Protein disulfide-isomerase A3	4

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
V9HVY3	P30101 Q5RDG4 G2HFN6 UPI0002C45977 A0A0H2UHM5 UPI00057B8988 UPI0006438C3E UPI00063F3F2E G1R041 UPI0004401151 +79	Homo sapiens (Human) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Trichechus manatus latirostris (Florida manatee) Rattus norvegicus (Rat) Camelus dromedarius (Dromedary) (Arabian camel) Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur) Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni) And more	505	UniRef90_P30101	Cluster: Protein disulfide-isomerase A3	90

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
V9HVY3	P30101 Q5RDG4 G2HFN6 UPI0002C45977 A0A0H2UHM5 UPI00057B8988 UPI0006438C3E UPI00063F3F2E Q4VIT4 A9X1C0 +104	Homo sapiens (Human) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Trichechus manatus latirostris (Florida manatee) Rattus norvegicus (Rat) Camelus dromedarius (Dromedary) (Arabian camel) Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur) Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli) Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) Papio anubis (Olive baboon) And more	505	UniRef50_P30101	Cluster: Protein disulfide-isomerase A3	115

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EU668338 mRNA. Translation: ACF94491.1. FJ224330 mRNA. Translation: ACI46022.1. CH471082 Genomic DNA. Translation: EAW77236.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_005304.3. NM_005313.4.
UniGeneⁱ	Hs.591095.

3D structure databases

SMRⁱ	V9HVY3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	V9HVY3.

MaxQBⁱ

V9HVY3.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	2923.
KEGGⁱ	hsa:2923.
UCSC genome browser More...UCSCⁱ	uc001zsu.4. human.

Organism-specific databases

CTDⁱ	2923.

CTDⁱ

2923.

Phylogenomic databases

eggNOGⁱ	KOG0190. Eukaryota. COG0526. LUCA.
KEGG Orthology (KO) More...KOⁱ	K08056.
OMAⁱ	VAIVKMD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05J9.

Miscellaneous databases

ChiTaRSⁱ	PDIA3. human.
GenomeRNAiⁱ	2923.

Gene expression databases

Bgeeⁱ	ENSG00000167004.
ExpressionAtlasⁱ	V9HVY3. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR005788. Disulphide_isomerase. IPR005792. Prot_disulphide_isomerase. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00085. Thioredoxin. 2 hits.
SUPFAMⁱ	SSF52833. SSF52833. 4 hits.
TIGRFAMsⁱ	TIGR01130. ER_PDI_fam. 1 hit. TIGR01126. pdi_dom. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00194. THIOREDOXIN_1. 2 hits. PS51352. THIOREDOXIN_2. 2 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	V9HVY3_HUMAN
Accessionⁱ	V9HVY3Primary (citable) accession number: V9HVY3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 19, 2014
	Last sequence update:	March 19, 2014
	Last modified:	August 30, 2017
	This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - V9HVY3 (V9HVY3_HUMAN)

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Protein disulfide-isomerase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ