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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

gid

Organism
Streptococcus mitis 27/7
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotationSAAS annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotationSAAS annotation

Cofactori

FADUniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 37FADUniRule annotation6

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processtRNA processingUniRule annotationSAAS annotation
LigandFADUniRule annotationSAAS annotation, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotationSAAS annotation (EC:2.1.1.74UniRule annotationSAAS annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:gidImported
Synonyms:trmFOUniRule annotation
ORF Names:U758_06870Imported
OrganismiStreptococcus mitis 27/7Imported
Taxonomic identifieri1415766 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000018726 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_01037. TrmFO. 1 hit.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
IPR004417. TrmFO.
PANTHERiPTHR11806. PTHR11806. 1 hit.
PTHR11806:SF2. PTHR11806:SF2. 1 hit.
PfamiView protein in Pfam
PF01134. GIDA. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
PROSITEiView protein in PROSITE
PS01281. GIDA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

V8I9Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNKPVPCFD MNLGSTQRGI SVVSQSYINV IGAGLAGSEA AYQIAERGIP
60 70 80 90 100
VKLYEMRGVK STPQHKTDNF AELVCSNSLR GDALTNAVGL LKEEMRRLGS
110 120 130 140 150
VILESAEATR VPAGGALAVD RDGFSQMVTE KVANHPLIEV VRDEITELPT
160 170 180 190 200
DVITVVATGP LTSDALAEKI HSLNDGDGFY FYDAAAPIID VNTIDMSKVY
210 220 230 240 250
LKSRYDKGEA AYLNAPMTKQ EFMDFHEALV NAEEAPLNSF EKEKYFEGCM
260 270 280 290 300
PIEVMAKRGI KTMLYGPMKP VGLEYPDDYT GPRDGEFKTP YAVVQLRQDN
310 320 330 340 350
AAGSLYNIVG FQTHLKWGEQ KRVFQMIPGL ENAEFVRYGV MHRNSYMDSP
360 370 380 390 400
NLLEQTYRSK KQPNLFFAGQ MTGVEGYVES AASGLVAGIN AARLFKGESE
410 420 430 440 450
AIFPETTAIG SLAHYITHAD SKHFQPMNVN FGIIKELEGE RIRDKKARYE
460
KIAERALSDL EEFLTV
Length:466
Mass (Da):51,563
Last modified:February 19, 2014 - v1
Checksum:i40807A12113A340E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AYRS01000012 Genomic DNA. Translation: ETD97879.1.

Genome annotation databases

EnsemblBacteriaiETD97879; ETD97879; U758_06870.
PATRICifig|1415766.3.peg.1322.

Similar proteinsi

Entry informationi

Entry nameiV8I9Y9_STRMT
AccessioniPrimary (citable) accession number: V8I9Y9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 19, 2014
Last sequence update: February 19, 2014
Last modified: February 28, 2018
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported