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Protein

Proteasome subunit alpha

Gene

prcA

Organism
Mycobacterium avium subsp. avium 10-9275
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotationSAAS annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotationSAAS annotation

Enzyme regulationi

The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Pathwayi: proteasomal Pup-dependent pathway

This protein is involved in the pathway proteasomal Pup-dependent pathway, which is part of Protein degradation.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway proteasomal Pup-dependent pathway and in Protein degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00997.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome alpha subunitUniRule annotation
Proteasome core protein PrcAUniRule annotation
Gene namesi
Name:prcAUniRule annotation
ORF Names:O972_11480Imported
OrganismiMycobacterium avium subsp. avium 10-9275Imported
Taxonomic identifieri1391991 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
Proteomesi
  • UP000018568 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation, ProteasomeUniRule annotationSAAS annotationImported

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliV7L3M2.
SMRiV7L3M2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.UniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H08XR.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00289_B. Proteasome_A_B. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR022296. Proteasome_asu_bac.
IPR001353. Proteasome_sua/b.
PANTHERiPTHR11599:SF69. PTHR11599:SF69. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03691. 20S_bact_alpha. 1 hit.
PROSITEiView protein in PROSITE
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

V7L3M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPYFISPE QAMRERSELA RKGIARGKSV VALVYAGGVL FVAENPSRSL
60 70 80 90 100
QKISELYDRV GFAAAGKFNE FDNLRRGGIQ FADTRGYAYD RRDVTGRQLA
110 120 130 140 150
NVYAQTLGTI FTEQAKPYEV ELCVAEVAHY GETKPPELYR ITYDGSIADE
160 170 180 190 200
PHFVVMGGTT EPITTALKDS YAENANLREA TRIAVRALRA GSESSNGDQS
210 220 230 240 250
ALDVGSLEVA ILDVNRPRRA FRRINRPTLE NLLRELDSNG SDGNGDAPEL

NGGSSD
Length:256
Mass (Da):28,078
Last modified:February 19, 2014 - v1
Checksum:i74B8A6ADF419D355
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AYNY01000369 Genomic DNA. Translation: ETB16745.1.
RefSeqiWP_003878079.1. NZ_AYNY01000369.1.

Genome annotation databases

EnsemblBacteriaiETB16745; ETB16745; O972_11480.
GeneIDi2720295.
PATRICifig|1391991.3.peg.2148.

Similar proteinsi

Entry informationi

Entry nameiV7L3M2_MYCAV
AccessioniPrimary (citable) accession number: V7L3M2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 19, 2014
Last sequence update: February 19, 2014
Last modified: March 28, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported