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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Klebsiella pneumoniae 909957
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotationSAAS annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (HMPREF1619_00013)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processCarbohydrate metabolism, Glucose metabolismUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotationSAAS annotation (EC:3.1.1.31UniRule annotationSAAS annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
ORF Names:HMPREF1619_04897Imported
OrganismiKlebsiella pneumoniae 909957Imported
Taxonomic identifieri1269006 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000017394 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_01605 6P_gluconolactonase, 1 hit
InterProiView protein in InterPro
IPR022528 6-phosphogluconolactonase_YbhE
IPR019405 Lactonase_7-beta_prop
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit
SUPFAMiSSF50974 SSF50974, 2 hits

Sequencei

Sequence statusi: Complete.

V0AV35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYNFQGAVI LKMKIPRAVR EGVVMKQTVY TASPESQQIH VWSLEADGKL
60 70 80 90 100
TLVQVVDAPG QVQPMVVSPN KEFLYVGVRP EFRVLAYRIT PDNGALTFAG
110 120 130 140 150
EAALPGSPTH ISTDRHGRFV FSASYNQGCV SVTPLHDGLP GETITVVEGL
160 170 180 190 200
EGCHSANISP DNRTLWVPAL KQDRICLFTL SDDGFLSAQE PAEVTTVEGA
210 220 230 240 250
GPRHMVFHPN QQYGYCVNEL NSSIDVWELK DPKGNIECVQ TLDMMPPDFS
260 270 280 290 300
GVRWAADIHI TPDGRHLYAC DRTASIITVF SVSEDGSVLA VEGYQPTETQ
310 320 330 340 350
PRGFNLDHSG KYLIAAGQKS HHIAVYDIVG EQGLLQEKGR YAVGQGPMWV

VVNAH
Length:355
Mass (Da):38,845
Last modified:January 22, 2014 - v1
Checksum:i7E162A5B82C58B57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AXUL01000187 Genomic DNA Translation: ESA97750.1

Genome annotation databases

EnsemblBacteriaiESA97750; ESA97750; HMPREF1619_04897
PATRICifig|1269006.3.peg.4312

Similar proteinsi

Entry informationi

Entry nameiV0AV35_KLEPN
AccessioniPrimary (citable) accession number: V0AV35
Entry historyiIntegrated into UniProtKB/TrEMBL: January 22, 2014
Last sequence update: January 22, 2014
Last modified: November 22, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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