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Reviewed, UniProtKB/Swiss-Prot Q14139 (UBE4A_HUMAN)

Last modified November 4, 2008. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ubiquitin conjugation factor E4 A
Gene names
Name: UBE4A
Synonyms: KIAA0126
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length1066 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3 By similarity.

Sequence similarities

Belongs to the ubiquitin conjugation factor E4 family.

Contains 1 U-box domain.

Sequence caution

The sequence AAH52643.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

The sequence AAH62695.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

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Ontologies

Keywords

   Biological processUbl conjugation pathway
   Coding sequence diversityAlternative splicing
   Technical term3D-structure
Direct protein sequencing

Gene Ontology (GO)

   Biological processubiquitin-dependent protein catabolic process

Traceable author statement. Source: ProtInc

   Cellular componentubiquitin ligase complex

Traceable author statement. Source: ProtInc

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

PTP4A3O753651EBI-1048119,EBI-1043866

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q14139-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q14139-2)

The sequence of this isoform differs from the canonical sequence as follows:
     241-241: H → REYMNKIY
Notes: No experimental confirmation available.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10661066Ubiquitin conjugation factor E4 A
PRO_0000194990

Regions

Domain991 – 105464U-box

Natural variations

Alternative sequence2411H → REYMNKIY in isoform 2.
VSP_013673

Experimental info

Sequence conflict2171P → L in BAA09475. Ref.1

Secondary structure

1 .................... 1066
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 10, 2005. Version 2.
Checksum: A735D670220F9DDA

FASTA1,066122,561
        10         20         30         40         50         60 
MTDQENNNNI SSNPFAALFG SLADAKQFAA IQKEQLKQQS DELPASPDDS DNSVSESLDE 

        70         80         90        100        110        120 
FDYSVAEISR SFRSQQEICE QLNINHMIQR IFLITLDNSD PSLKSGNGIP SRCVYLEEMA 

       130        140        150        160        170        180 
VELEDQDWLD MSNVEQALFA RLLLQDPGNH LINMTSSTTL NLSADRDAGE RHIFCYLYSC 

       190        200        210        220        230        240 
FQRAKEEITK VPENLLPFAV QCRNLTVSNT RTVLLTPEIY VDQNIHEQLV DLMLEAIQGA 

       250        260        270        280        290        300 
HFEDVTEFLE EVIEALILDE EVRTFPEVMI PVFDILLGRI KDLELCQILL YAYLDILLYF 

       310        320        330        340        350        360 
TRQKDMAKVF VEYIQPKDPT NGQMYQKTLL GVILSISCLL KTPGVVENHG YFLNPSRSSP 

       370        380        390        400        410        420 
QEIKVQEANI HQFMAQFHEK IYQMLKNLLQ LSPETKHCIL SWLGNCLHAN AGRTKIWANQ 

       430        440        450        460        470        480 
MPEIFFQMYA SDAFFLNLGA ALLKLCQPFC KPRSSRLLTF NPTYCALKEL NDEERKIKNV 

       490        500        510        520        530        540 
HMRGLDKETC LIPAVQEPKF PQNYNLVTEN LALTEYTLYL GFHRLHDQMV KINQNLHRLQ 

       550        560        570        580        590        600 
VAWRDAQQSS SPAADNLREQ FERLMTIYLS TKTAMTEPQM LQNCLNLQVS MAVLLVQLAI 

       610        620        630        640        650        660 
GNEGSQPIEL TFPLPDGYSS LAYVPEFFAD NLGDFLIFLR RFADDILETS ADSLEHVLHF 

       670        680        690        700        710        720 
ITIFTGSIER MKNPHLRAKL AEVLEAVMPH LDQTPNPLVS SVFHRKRVFC NFQYAPQLAE 

       730        740        750        760        770        780 
ALIKVFVDIE FTGDPHQFEQ KFNYRRPMYP ILRYMWGTDT YRESIKDLAD YASKNLEAMN 

       790        800        810        820        830        840 
PPLFLRFLNL LMNDAIFLLD EAIQYLSKIK IQQIEKDRGE WDSLTPEARR EKEAGLQMFG 

       850        860        870        880        890        900 
QLARFHNIMS NETIGTLAFL TSEIKSLFVH PFLAERIISM LNYFLQHLVG PKMGALKVKD 

       910        920        930        940        950        960 
FSEFDFKPQQ LVSDICTIYL NLGDEENFCA TVPKDGRSYS PTLFAQTVRV LKKINKPGNM 

       970        980        990       1000       1010       1020 
IMAFSNLAER IKSLADLQQQ EEETYADACD EFLDPIMSTL MCDPVVLPSS RVTVDRSTIA 

      1030       1040       1050       1060 
RHLLSDQTDP FNRSPLTMDQ IRPNTELKEK IQRWLAERKQ QKEQLE

« Hide

Isoform 2 [UniParc].

Checksum: 11AC6B62DD4076E7
Show »

1,073123,522

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References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
DNA Res. 2:167-174(1995) [PubMed: 8590280] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Bone marrow.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
Nat. Biotechnol. 21:566-569(2003) [PubMed: 12665801] [Abstract]
Cited for: PROTEIN SEQUENCE OF 545-558.
Tissue: Platelet.
[4]"Solution structure of the U-box in human ubiquitin conjugation factor E4A."
RIKEN structural genomics initiative (RSGI)
Submitted (MAY-2004) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 977-1061.
+Additional computationally mapped references.

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Cross-references

Sequence databases

D50916 mRNA. Translation: BAA09475.2. Different initiation.
BC052643 mRNA. Translation: AAH52643.1. Sequence problems.
BC062695 mRNA. Translation: AAH62695.1. Sequence problems.
BC111417 mRNA. Translation: AAI11418.1.
BC112367 mRNA. Translation: AAI12368.1.
RefSeqNP_004779.2.
UniGeneHs.602967
Hs.75275

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1WGMNMR-A977-1061[»]
ModBaseSearch...

Protein-protein interaction databases

IntActQ14139.

PTM databases

PhosphoSiteQ14139.

Genome annotation databases

EnsemblENSG00000110344. Homo sapiens. [Contig view]
GeneID9354.
KEGGhsa:9354.

Organism-specific databases

H-InvDBHIX0010181.
HGNCHGNC:12499. UBE4A.
MIM603753. gene.
PharmGKBPA37147.
HUGESearch...
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ14139.
HOVERGENQ14139.

Gene expression databases

ArrayExpressQ14139.
CleanExHS_UBE4A.
GermOnlineENSG00000110344. Homo sapiens.

Family and domain databases

InterProIPR003613. Ubox.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
Gene3DG3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
PfamPF04564. U-box. 1 hit.
[Graphical view]
SMARTSM00504. Ubox. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio35029.
SOURCESearch...

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Entry information

Entry nameUBE4A_HUMAN
AccessionPrimary (citable) accession number: Q14139
Secondary accession number(s): Q2M1H0, Q6P5T4, Q7Z639
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 10, 2005
Last modified: November 4, 2008
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents