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U5S3A4

- U5S3A4_9CLOT

UniProt

U5S3A4 - U5S3A4_9CLOT

Protein

Xylose isomerase

Gene

xylA

Organism
Clostridium autoethanogenum DSM 10061
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 8 (01 Oct 2014)
      Sequence version 1 (22 Jan 2014)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei101 – 1011UniRule annotation
    Active sitei104 – 1041UniRule annotation
    Metal bindingi232 – 2321Magnesium 1UniRule annotation
    Metal bindingi268 – 2681Magnesium 1UniRule annotation
    Metal bindingi268 – 2681Magnesium 2UniRule annotation
    Metal bindingi271 – 2711Magnesium 2UniRule annotation
    Metal bindingi296 – 2961Magnesium 1UniRule annotation
    Metal bindingi307 – 3071Magnesium 2UniRule annotation
    Metal bindingi309 – 3091Magnesium 2UniRule annotation
    Metal bindingi339 – 3391Magnesium 1UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xylose isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-HAMAP
    2. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Carbohydrate metabolism, Pentose shuntUniRule annotationSAAS annotation, Xylose metabolismUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
    Gene namesi
    Name:xylAUniRule annotation
    ORF Names:CAETHG_3932Imported
    OrganismiClostridium autoethanogenum DSM 10061Imported
    Taxonomic identifieri1341692 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000017590: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliU5S3A4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xylose isomerase family.UniRule annotation

    Phylogenomic databases

    KOiK01805.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00455. Xylose_isom_A.
    InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PRINTSiPR00688. XYLOSISMRASE.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
    PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    U5S3A4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEYFNNVSK INYEGPDSKN PYSFKYYNPD EVIGGKKMRD HLRFSMSYWH    50
    TLTANGTDQF GSGTMVRPWD NVNDKMELAK ARMEAAFEFM NKLDIDYFCF 100
    HDRDIAPEGK DLAETNKNLD EIVAMCKDLM KKNNKKLLWG TANLFNNPRF 150
    VHGAGTTCNA NVYAYSAAQL KKAIEVTNEL GGENYVFWGG REGYETLLNT 200
    DMGFEMDNFA RILQMAVDYA KKIGFKGQFL IEPKPKEPTK HQYDFDVATV 250
    LGFLRKYKLE DYFKINIEAN HATLAGHTFQ HEICLARNNN ALGSLDANQG 300
    DPHLGWDTDQ FPTNVYDTTL SMYEVLKNGG IAPGGLNFDA KVRRASFEPE 350
    DLFLAYIAGM DSFAKGLRVA YKLLQDAPIE NFIKERYSSF STGIGKDIVD 400
    GKVGFDELEK YALENNVINN KSGRQEYLES VVNQYILEDK 440
    Length:440
    Mass (Da):50,112
    Last modified:January 22, 2014 - v1
    Checksum:iA76171A640A04875
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP006763 Genomic DNA. Translation: AGY78133.1.
    RefSeqiYP_008701389.1. NC_022592.1.

    Genome annotation databases

    EnsemblBacteriaiAGY78133; AGY78133; CAETHG_3932.
    GeneIDi17337349.
    KEGGicah:CAETHG_3932.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP006763 Genomic DNA. Translation: AGY78133.1 .
    RefSeqi YP_008701389.1. NC_022592.1.

    3D structure databases

    ProteinModelPortali U5S3A4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AGY78133 ; AGY78133 ; CAETHG_3932 .
    GeneIDi 17337349.
    KEGGi cah:CAETHG_3932.

    Phylogenomic databases

    KOi K01805.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00455. Xylose_isom_A.
    InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00688. XYLOSISMRASE.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
    PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of single-molecule sequencing and hybrid approaches for finishing the genome of Clostridium autoethanogenum and analysis of CRISPR systems in industrial relevant Clostridia."
      Brown S.D., Nagaraju S., Utturkar S., De Tissera S., Segovia S., Mitchell W., Land M.L., Dassanayake A., Kopke M.
      Biotechnol. Biofuels 7:40-40(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 10061Imported.

    Entry informationi

    Entry nameiU5S3A4_9CLOT
    AccessioniPrimary (citable) accession number: U5S3A4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 22, 2014
    Last sequence update: January 22, 2014
    Last modified: October 1, 2014
    This is version 8 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3