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Protein
Submitted name:

Metalloprotease-disintegrin 12 transmembrane isoform La

Gene

ADAM12

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi347Zinc; catalyticPROSITE-ProRule annotation1
Active sitei348PROSITE-ProRule annotation1
Metal bindingi351Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi357Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, IntegrinImported, MetalloproteaseImported, Protease
LigandMetal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Metalloprotease-disintegrin 12 transmembrane isoform LaImported
Gene namesi
Name:ADAM12Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei705 – 726HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500466292129 – 906Sequence analysisAdd BLAST878

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi479 ↔ 499PROSITE-ProRule annotation
Disulfide bondi657 ↔ 667PROSITE-ProRule annotation
Disulfide bondi675 ↔ 684PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiU5NE98.
PeptideAtlasiU5NE98.
PRIDEiU5NE98.

Structurei

3D structure databases

ProteinModelPortaliU5NE98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini211 – 413Peptidase M12BInterPro annotationAdd BLAST203
Domaini421 – 507DisintegrinInterPro annotationAdd BLAST87
Domaini653 – 685EGF-likeInterPro annotationAdd BLAST33

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.

Family and domain databases

CDDicd04269. ZnMc_adamalysin_II_like. 1 hit.
Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR000742. EGF-like_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
IPR034027. Reprolysin_adamalysin.
PfamiView protein in Pfam
PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS50026. EGF_3. 1 hit.

Sequencei

Sequence statusi: Complete.

U5NE98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVGSG
60 70 80 90 100
DLWIPVKSFD SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL
110 120 130 140 150
QDGTDVSLAR NYTGHCYYHG HVRGYSDSAV SLSTCSGLRG LIVFENESYV
160 170 180 190 200
LEPMKSATNR YKLFPAKKLK SVRGSCGSHH NTPNLAAKNV FPPPSQTWAR
210 220 230 240 250
RHKRETLKAT KYVELVIVAD NREFQRQGKD LEKVKQRLIE IANHVDKFYR
260 270 280 290 300
PLNIRIVLVG VEVWNDMDKC SVSQDPFTSL HEFLDWRKMK LLPRKSHDNA
310 320 330 340 350
QLVSGVYFQG TTIGMAPIMS MCTADQSGGI VMDHSDNPLG AAVTLAHELG
360 370 380 390 400
HNFGMNHDTL DRGCSCQMAV EKGGCIMNAS TGYPFPMVFS SCSRKDLETS
410 420 430 440 450
LEKGMGVCLF NLPEVRESFG GQKCGNRFVE EGEECDCGEP EECMNRCCNA
460 470 480 490 500
TTCTLKPDAV CAHGLCCEDC QLKPAGTACR DSSNSCDLPE FCTGASPHCP
510 520 530 540 550
ANVYLHDGHS CQDVDGYCYN GICQTHEQQC VTLWGPGAKP APGICFERVN
560 570 580 590 600
SAGDPYGNCG KVSKSSFAKC EMRDAKCGKI QCQGGASRPV IGTNAVSIET
610 620 630 640 650
NIPLQQGGRI LCRGTHVYLG DDMPDPGLVL AGTKCADGKI CLNRQCQNIS
660 670 680 690 700
VFGVHECAMQ CHGRGVCNNR KNCHCEAHWA PPFCDKFGFG GSTDSGPIRQ
710 720 730 740 750
ADNQGLTIGI LVTILCLLAA GFVVYLKRKT LIRLLFTNKK TTIEKLRCVR
760 770 780 790 800
PSRPPRGFQP CQAHLGHLGK GLMRKPPDSY PPKDNPRRLL QCQNVDISRP
810 820 830 840 850
LNGLNVPQPQ STQRVLPPLH RAPRAPSVPA RPLPAKPALR QAQGTCKPNP
860 870 880 890 900
PQKPLPADPL ARTTRLTHAL ARTPGQWETG LRLAPLRPAP QYPHQVPRST

HTAYIK
Length:906
Mass (Da):99,217
Last modified:January 22, 2014 - v1
Checksum:i123529DAF0A11D91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF444157 mRNA. Translation: AGX93290.1.
RefSeqiNP_001275902.1. NM_001288973.1.
UniGeneiHs.594351.
Hs.741333.

Genome annotation databases

GeneIDi8038.

Similar proteinsi

Entry informationi

Entry nameiU5NE98_HUMAN
AccessioniPrimary (citable) accession number: U5NE98
Entry historyiIntegrated into UniProtKB/TrEMBL: January 22, 2014
Last sequence update: January 22, 2014
Last modified: September 27, 2017
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation