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Protein
Submitted name:

Metalloprotease-disintegrin 12 transmembrane isoform La

Gene

ADAM12

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, IntegrinImported, MetalloproteaseImported, Protease

Names & Taxonomyi

Protein namesi
Submitted name:
Metalloprotease-disintegrin 12 transmembrane isoform LaImported
Gene namesi
Name:ADAM12Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei705 – 72622HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 906878Sequence analysisPRO_5004662921Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiU5NE98.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357668.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini211 – 413203Peptidase M12BInterPro annotationAdd
BLAST
Domaini421 – 50787DisintegrinInterPro annotationAdd
BLAST
Domaini653 – 68533EGF-likeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 disintegrin domain.UniRule annotation
Contains 1 peptidase M12B domain.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR000742. EGF-like_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

U5NE98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVGSG
60 70 80 90 100
DLWIPVKSFD SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL
110 120 130 140 150
QDGTDVSLAR NYTGHCYYHG HVRGYSDSAV SLSTCSGLRG LIVFENESYV
160 170 180 190 200
LEPMKSATNR YKLFPAKKLK SVRGSCGSHH NTPNLAAKNV FPPPSQTWAR
210 220 230 240 250
RHKRETLKAT KYVELVIVAD NREFQRQGKD LEKVKQRLIE IANHVDKFYR
260 270 280 290 300
PLNIRIVLVG VEVWNDMDKC SVSQDPFTSL HEFLDWRKMK LLPRKSHDNA
310 320 330 340 350
QLVSGVYFQG TTIGMAPIMS MCTADQSGGI VMDHSDNPLG AAVTLAHELG
360 370 380 390 400
HNFGMNHDTL DRGCSCQMAV EKGGCIMNAS TGYPFPMVFS SCSRKDLETS
410 420 430 440 450
LEKGMGVCLF NLPEVRESFG GQKCGNRFVE EGEECDCGEP EECMNRCCNA
460 470 480 490 500
TTCTLKPDAV CAHGLCCEDC QLKPAGTACR DSSNSCDLPE FCTGASPHCP
510 520 530 540 550
ANVYLHDGHS CQDVDGYCYN GICQTHEQQC VTLWGPGAKP APGICFERVN
560 570 580 590 600
SAGDPYGNCG KVSKSSFAKC EMRDAKCGKI QCQGGASRPV IGTNAVSIET
610 620 630 640 650
NIPLQQGGRI LCRGTHVYLG DDMPDPGLVL AGTKCADGKI CLNRQCQNIS
660 670 680 690 700
VFGVHECAMQ CHGRGVCNNR KNCHCEAHWA PPFCDKFGFG GSTDSGPIRQ
710 720 730 740 750
ADNQGLTIGI LVTILCLLAA GFVVYLKRKT LIRLLFTNKK TTIEKLRCVR
760 770 780 790 800
PSRPPRGFQP CQAHLGHLGK GLMRKPPDSY PPKDNPRRLL QCQNVDISRP
810 820 830 840 850
LNGLNVPQPQ STQRVLPPLH RAPRAPSVPA RPLPAKPALR QAQGTCKPNP
860 870 880 890 900
PQKPLPADPL ARTTRLTHAL ARTPGQWETG LRLAPLRPAP QYPHQVPRST

HTAYIK
Length:906
Mass (Da):99,217
Last modified:January 22, 2014 - v1
Checksum:i123529DAF0A11D91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF444157 mRNA. Translation: AGX93290.1.
RefSeqiNP_001275902.1. NM_001288973.1.
UniGeneiHs.594351.
Hs.741333.

Genome annotation databases

GeneIDi8038.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF444157 mRNA. Translation: AGX93290.1.
RefSeqiNP_001275902.1. NM_001288973.1.
UniGeneiHs.594351.
Hs.741333.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357668.

Proteomic databases

PaxDbiU5NE98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8038.

Organism-specific databases

CTDi8038.

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.

Miscellaneous databases

ChiTaRSiADAM12. human.
GenomeRNAii8038.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR000742. EGF-like_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Alternative mRNA Splicing Generates Two Distinct ADAM12 Prodomain Variants."
    Duhachek-Muggy S., Li H., Qi Y., Zolkiewska A.
    PLoS ONE 8:E75730-E75730(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiU5NE98_HUMAN
AccessioniPrimary (citable) accession number: U5NE98
Entry historyi
Integrated into UniProtKB/TrEMBL: January 22, 2014
Last sequence update: January 22, 2014
Last modified: June 8, 2016
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.