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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Clostridioides difficile T5
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processAntibiotic resistanceUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotationImported
ORF Names:BN163_830003Imported
OrganismiClostridioides difficile T5Imported
Taxonomic identifieri1215059 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000018344 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 35HelicalUniRule annotationAdd BLAST24
Transmembranei47 – 69HelicalUniRule annotationAdd BLAST23
Transmembranei90 – 109HelicalUniRule annotationAdd BLAST20
Transmembranei115 – 136HelicalUniRule annotationAdd BLAST22
Transmembranei148 – 169HelicalUniRule annotationAdd BLAST22
Transmembranei189 – 211HelicalUniRule annotationAdd BLAST23
Transmembranei223 – 244HelicalUniRule annotationAdd BLAST22
Transmembranei256 – 273HelicalUniRule annotationAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Structurei

3D structure databases

ProteinModelPortaliU3UL53.
SMRiU3UL53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiView protein in InterPro
IPR003824. UppP.
PANTHERiPTHR30622. PTHR30622. 1 hit.
PfamiView protein in Pfam
PF02673. BacA. 1 hit.
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

U3UL53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METFSLLEIF KAVILGIVQG ITEWLPVSST GHMILVDEFI KLNFSNTFIS
60 70 80 90 100
TFLVVIQFGS ILAVLVIFFR KLNPFDSAKN IKQKKETVRL WLKVIIAVIP
110 120 130 140 150
SGVIGILFED DIDRLFFNST VVAIALIVYG IIMIGLEKRN KRPKYKDFSQ
160 170 180 190 200
VTYKLALCIG LFQCLALIPG TSRSGSTIIG AVLLGTSRYV AAEFSFFLAI
210 220 230 240 250
PTMLGASALK LLKAGFGFTG FEWLILGVGS VVAFVVSIVV IKFFMDYIKK
260 270
HDFKVFGYYR IVLGIVVLAY FFLL
Length:274
Mass (Da):30,560
Last modified:December 11, 2013 - v1
Checksum:i7724B00549DC8F98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAMB01000210 Genomic DNA. Translation: CCK90125.1.
RefSeqiWP_009905410.1. NZ_HF677356.1.

Genome annotation databases

EnsemblBacteriaiCCK90125; CCK90125; BN163_830003.
GeneIDi31352920.

Similar proteinsi

Entry informationi

Entry nameiU3UL53_CLODI
AccessioniPrimary (citable) accession number: U3UL53
Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2013
Last sequence update: December 11, 2013
Last modified: September 27, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported