Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Potassium channel subfamily k member 2 variant 1

Gene

KCNK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel subfamily k member 2 variant 1Imported
Gene namesi
Name:KCNK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei60 – 79HelicalSequence analysisAdd BLAST20
Transmembranei135 – 156HelicalSequence analysisAdd BLAST22
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei219 – 240HelicalSequence analysisAdd BLAST22
Transmembranei252 – 270HelicalSequence analysisAdd BLAST19
Transmembranei285 – 307HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiU3N834.

Expressioni

Gene expression databases

BgeeiENSG00000082482.
ExpressionAtlasiU3N834. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000394033.

Structurei

3D structure databases

ProteinModelPortaliU3N834.
SMRiU3N834.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 191Ion_trans_2InterPro annotationAdd BLAST64
Domaini230 – 308Ion_trans_2InterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003976. 2pore_dom_K_chnl_TREK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.

Sequencei

Sequence statusi: Complete.

U3N834-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNPRAKRDF YLAAPDLLDP KSAAQNSKPR LSFSTKPTVL ASRVESDTTI
60 70 80 90 100
NVMKWKTVST IFLVVVLYLI IGATVFKALE QPHEISQRTT IVIQKQTFIS
110 120 130 140 150
QHSCVNSTEL DELIQQIVAA INAGIIPLGN TSNQISHWDL GSSFFFAGTV
160 170 180 190 200
ITTIGFGNIS PRTEGGKIFC IIYALLGIPL FGFLLAGVGD QLGTIFGKGI
210 220 230 240 250
AKVEDTFIKW NVSQTKIRII STIIFILFGC VLFVALPAII FKHIEGWSAL
260 270 280 290 300
DAIYFVVITL TTIGFGDYVA GGSDIEYLDF YKPVVWFWIL VGLAYFAAVL
310 320 330 340 350
SMIGDWLRVI SKKTKEEVGE FRAHAAEWTA NVTAEFKETR RRLSVEIYDK
360 370 380 390 400
FQRATSIKRK LSAELAGNHN QELTPCRRTL SVNHLTSERD VLPPLLKTES
410 420
IYLNGLTPHC AGEEIAVIEN IK
Length:422
Mass (Da):46,888
Last modified:December 11, 2013 - v1
Checksum:i1AD4E0B5C1B6CBE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF182338 mRNA. Translation: AGW27105.1.
RefSeqiNP_001017424.1. NM_001017424.2.
XP_016856737.1. XM_017001248.1.
UniGeneiHs.497745.

Genome annotation databases

GeneIDi3776.
UCSCiuc001hko.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF182338 mRNA. Translation: AGW27105.1.
RefSeqiNP_001017424.1. NM_001017424.2.
XP_016856737.1. XM_017001248.1.
UniGeneiHs.497745.

3D structure databases

ProteinModelPortaliU3N834.
SMRiU3N834.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000394033.

Proteomic databases

PaxDbiU3N834.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3776.
UCSCiuc001hko.4. human.

Organism-specific databases

CTDi3776.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.

Miscellaneous databases

ChiTaRSiKCNK2. human.
GenomeRNAii3776.

Gene expression databases

BgeeiENSG00000082482.
ExpressionAtlasiU3N834. baseline and differential.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003976. 2pore_dom_K_chnl_TREK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiU3N834_HUMAN
AccessioniPrimary (citable) accession number: U3N834
Entry historyi
Integrated into UniProtKB/TrEMBL: December 11, 2013
Last sequence update: December 11, 2013
Last modified: November 2, 2016
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.