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Protein
Submitted name:

Potassium channel subfamily k member 2 variant 1

Gene

KCNK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotationImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel subfamily k member 2 variant 1Imported
Gene namesi
Name:KCNK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000082482.13

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei60 – 79HelicalSequence analysisAdd BLAST20
Transmembranei135 – 156HelicalSequence analysisAdd BLAST22
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei219 – 240HelicalSequence analysisAdd BLAST22
Transmembranei252 – 270HelicalSequence analysisAdd BLAST19
Transmembranei285 – 307HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSG00000082482
ExpressionAtlasiU3N834 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliU3N834
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 191Ion_trans_2InterPro annotationAdd BLAST64
Domaini230 – 308Ion_trans_2InterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418 Eukaryota
COG1226 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003976 2pore_dom_K_chnl_TREK
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PRINTSiPR01333 2POREKCHANEL
PR01499 TREKCHANNEL

Sequencei

Sequence statusi: Complete.

U3N834-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNPRAKRDF YLAAPDLLDP KSAAQNSKPR LSFSTKPTVL ASRVESDTTI
60 70 80 90 100
NVMKWKTVST IFLVVVLYLI IGATVFKALE QPHEISQRTT IVIQKQTFIS
110 120 130 140 150
QHSCVNSTEL DELIQQIVAA INAGIIPLGN TSNQISHWDL GSSFFFAGTV
160 170 180 190 200
ITTIGFGNIS PRTEGGKIFC IIYALLGIPL FGFLLAGVGD QLGTIFGKGI
210 220 230 240 250
AKVEDTFIKW NVSQTKIRII STIIFILFGC VLFVALPAII FKHIEGWSAL
260 270 280 290 300
DAIYFVVITL TTIGFGDYVA GGSDIEYLDF YKPVVWFWIL VGLAYFAAVL
310 320 330 340 350
SMIGDWLRVI SKKTKEEVGE FRAHAAEWTA NVTAEFKETR RRLSVEIYDK
360 370 380 390 400
FQRATSIKRK LSAELAGNHN QELTPCRRTL SVNHLTSERD VLPPLLKTES
410 420
IYLNGLTPHC AGEEIAVIEN IK
Length:422
Mass (Da):46,888
Last modified:December 11, 2013 - v1
Checksum:i1AD4E0B5C1B6CBE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF182338 mRNA Translation: AGW27105.1
RefSeqiNP_001017424.1, NM_001017424.2
XP_016856737.1, XM_017001248.1
UniGeneiHs.497745

Genome annotation databases

GeneIDi3776
UCSCiuc001hko.4 human

Similar proteinsi

Entry informationi

Entry nameiU3N834_HUMAN
AccessioniPrimary (citable) accession number: U3N834
Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2013
Last sequence update: December 11, 2013
Last modified: March 28, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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