ID   U3KGF1_FICAL            Unreviewed;       398 AA.
AC   U3KGF1;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   24-JAN-2024, entry version 56.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   Name=INPP5D {ECO:0000313|Ensembl:ENSFALP00000014105.2};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000014105.2, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000014105.2, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000014105.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-
CC         (2->8)- glycosidic linkages of terminal sialic acid residues in
CC         oligosaccharides, glycoproteins, glycolipids, colominic acid and
CC         synthetic substrates.; EC=3.2.1.18;
CC         Evidence={ECO:0000256|ARBA:ARBA00000427};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   RefSeq; XP_005050993.1; XM_005050936.1.
DR   RefSeq; XP_005050994.1; XM_005050937.2.
DR   RefSeq; XP_005050995.1; XM_005050938.1.
DR   RefSeq; XP_005050996.1; XM_005050939.1.
DR   AlphaFoldDB; U3KGF1; -.
DR   STRING; 59894.ENSFALP00000014105; -.
DR   Ensembl; ENSFALT00000014163.2; ENSFALP00000014105.2; ENSFALG00000013517.2.
DR   GeneID; 101808679; -.
DR   KEGG; fab:101808679; -.
DR   CTD; 4759; -.
DR   eggNOG; ENOG502QSFT; Eukaryota.
DR   GeneTree; ENSGT00940000156202; -.
DR   HOGENOM; CLU_024620_2_1_1; -.
DR   Proteomes; UP000016665; Chromosome 9.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF6; SIALIDASE-2; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT   DOMAIN          65..357
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   398 AA;  44837 MW;  F8A2B964283BE7F1 CRC64;
     MLNCIRPRAV PQCANPCSTM AAFPVLEQET LFRNGSWSYR IPALLYLPRF SMILAFAEER
     EDLVDEHAKL IAMRRGVYDP ATQHVQWKRM ETLVSAQLEG HRSMNPCPVY DEVSGKLILF
     FIAVPGKISE QHQLRTKTNL VRLCYVTSMD QGHTWSTAQD VTDRTIRNEY KNWATFAVGP
     GHGLQLLNEA RSLVIPAYAY RILDPKKHPT PHAFCFISSD HGTTWEKGNF VGEESAVECQ
     VAEVHTCGRK VLYCNARSNR GARIQAVSYN HGLDFKGGQR VEMLVEPPSG CHGSVTAFPP
     PPDATCQDSW LLYAHPTDPR GRKDLGIYLN KSPLNPAHWT KPSILFKGLC AYSDLQYMGV
     GPDGSPLFSC LFEYGTHRQC EEIIFVMFTL KQAFPSEH
//