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Protein
Submitted name:

Proprotein convertase subtilisin/kexin type 1

Gene

PCSK1

Organism
Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiS08.072.

Names & Taxonomyi

Protein namesi
Submitted name:
Proprotein convertase subtilisin/kexin type 1Imported
Gene namesi
Name:PCSK1Imported
OrganismiFicedula albicollis (Collared flycatcher) (Muscicapa albicollis)Imported
Taxonomic identifieri59894 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesMuscicapidaeFicedula
Proteomesi
  • UP000016665 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500464464429 – 749Sequence analysisAdd BLAST721

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 111S8_pro-domainInterPro annotationAdd BLAST77
Domaini159 – 443Peptidase S8InterPro annotationAdd BLAST285
Domaini505 – 592P_proproteinInterPro annotationAdd BLAST88
Domaini710 – 747Proho_convertInterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00750000117358.
KOiK01359.
OMAiFEPRALK.
OrthoDBiEOG091G05HI.

Family and domain databases

CDDicd04059. Peptidases_S8_Protein_converta. 1 hit.
Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiView protein in InterPro
IPR008979. Galactose-bd-like.
IPR034182. Kexin/furin.
IPR009020. Peptidase/Inhibitor_I9.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR022005. Proho_convert.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
PfamiView protein in Pfam
PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF12177. Proho_convert. 1 hit.
PF16470. S8_pro-domain. 1 hit.
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiView protein in PROSITE
PS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

U3JJX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRRWAGRC AALAVLLAAW SLPQGGSAGR LFLNEWAAEI PAGPDAARAI
60 70 80 90 100
ADELDYDLVG QIGSLKNHYL FRHKSHPRRS RRSATHMTKR LSDDERVSWA
110 120 130 140 150
EQQYEKKRTK RASVRDSAES LFNDPMWNQQ WYLQDTRITP SLPKLDLHVI
160 170 180 190 200
PVWQKGFTGK GVVITVLDDG LEWNHTDIYA NYDPKASYDF NDNDHDPFPR
210 220 230 240 250
YDPTNENKHG TRCAGEIAMQ ANNRKCGVGV AYNSRVGGIR MLDGIVTDAI
260 270 280 290 300
EASSIGFNPE HVDIYSASWG PNDDGKTVEG PGRLAQKAFE YGINQGRNGK
310 320 330 340 350
GSIFVWASGN GGRQGDNCDC DGYTDSIYTI SISSASQQGL SPWYAEKCSS
360 370 380 390 400
TLATAYSSGD YTDQRITSVD LHNECTETHT GTSASAPLAA GIFALALEAN
410 420 430 440 450
PDLTWRDMQH LVVWTSEYDP LAGNPGWKKN GAGLMVNSRF GFGLLNANAL
460 470 480 490 500
VDLADPKRWK GVPEKRECIV KDKSFEPRLL RADEEVIIEI PTKACEGQEN
510 520 530 540 550
SIASLEHVQL EATIEYSRRG DLHVTLVSPS GTSTVLLAER ERDKSPNGFK
560 570 580 590 600
NWDFMSVHTW GENPAGTWIL RITDMSRRIQ NEGRIVNWKL ILHGTTTQPE
610 620 630 640 650
HMKQPRVYTS YNAVQNDRRG VEKMTDLVED HTTLESLSEK PKATEETSSS
660 670 680 690 700
SDKAEDKIPS EAMLHLLQSA FSRQMDQKQL PKKTASKKLN IPYEHFYQAL
710 720 730 740
KKLNKPSQLR GSEESLYSDY VDLFYNAKPY KHRDDRLLQA LVDIINEGN
Length:749
Mass (Da):83,839
Last modified:November 13, 2013 - v1
Checksum:i79C42B2B7597B741
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGTO01001632 Genomic DNA. No translation available.
RefSeqiXP_005061274.1. XM_005061217.1.

Genome annotation databases

EnsembliENSFALT00000003090; ENSFALP00000003077; ENSFALG00000002956.
GeneIDi101816616.
KEGGifab:101816616.

Similar proteinsi

Entry informationi

Entry nameiU3JJX3_FICAL
AccessioniPrimary (citable) accession number: U3JJX3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: August 30, 2017
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported