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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

SDHA

Organism
Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:SDHAImported
OrganismiFicedula albicollis (Collared flycatcher) (Muscicapa albicollis)Imported
Taxonomic identifieri59894 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesMuscicapidaeFicedula
Proteomesi
  • UP000016665 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 458FAD_binding_2InterPro annotationAdd BLAST395
Domaini513 – 665Succ_DH_flav_CInterPro annotationAdd BLAST153

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00910000144277
KOiK00234
OMAiGDSPWEH
OrthoDBiEOG091G041Z

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

U3JHG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAARGLA KRWLRPAAAS RAWPAACQAP ARNLHFTVYG KKNASTKVSD
60 70 80 90 100
SISTQYPVVD HEFDAVVVGA GGAGLRAAFG LSEAGFNTAC VTKLFPTRSH
110 120 130 140 150
TVAAQGGINA ALGNMEDDNW RWHFYDTVKG SDWLGDQDAI HYMTEQAPAA
160 170 180 190 200
VIELENYGMP FSRTEEGKIY QRAFGGQSLQ FGKGGQAHRC CCVADRTGHS
210 220 230 240 250
LLHTLYGRSL RYDTSYFVEY FALDLLMENG ECRGVIALCI EDGTIHRFRA
260 270 280 290 300
KNTVIATGGY GRTYFSCTSA HTSTGDGTAM VTRAGLPCQD LEFVQFHPTG
310 320 330 340 350
IYGAGCLITE GCRGEGGILI NSQGERFMER YAPVAKDLAS RDVVSRSMTI
360 370 380 390 400
EIREGRGCGP EKDHVYLQLH HLPPQQLATR LPGISETAMI FAGVDVTKEP
410 420 430 440 450
IPVLPTVHYN MGGIPTNYKG QVITHVNGED KVVPGLYACG EAASASVHGA
460 470 480 490 500
NRLGANSLLD LVVFGRACAL TIANTCKPGE PVPPIKPNAG EESVANLDKL
510 520 530 540 550
RFADGSIRTS ELRLSMQKAM QSHAAVFRTG SVLQEGCEIL SKIYGDLAHL
560 570 580 590 600
KTFDRGIVWN TDLVETLELQ NLMLCALQTI YGAEARKESR GAHAREDYKL
610 620 630 640 650
RVDEFDYSKP LEGQQRKPFE EHWRKHTLSY VDIPTGKVTL KYRPVIDRTL
660
NEEDCQTVPP AIRSY
Length:665
Mass (Da):72,723
Last modified:November 13, 2013 - v1
Checksum:iC7AF9E5816C525BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGTO01022153 Genomic DNA No translation available.
RefSeqiXP_005041812.1, XM_005041755.2

Genome annotation databases

EnsembliENSFALT00000002232; ENSFALP00000002220; ENSFALG00000002129
GeneIDi101819469
KEGGifab:101819469

Similar proteinsi

Entry informationi

Entry nameiU3JHG6_FICAL
AccessioniPrimary (citable) accession number: U3JHG6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: May 23, 2018
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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