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Protein

Ribonuclease

Gene

RNASEH2A

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotation, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
RibonucleaseUniRule annotation (EC:3.1.26.-UniRule annotation)
Gene namesi
Name:RNASEH2AImported
OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 241RNase_HIIInterPro annotationAdd BLAST211

Sequence similaritiesi

Belongs to the RNase HII family.UniRule annotation

Family and domain databases

Gene3Di1.10.10.460, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR004649 RNase_H2_suA
IPR001352 RNase_HII/HIII
IPR024567 RNase_HII/HIII_dom
IPR023160 RNase_HII_hlx-loop-hlx_cap_dom
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10954 PTHR10954, 1 hit
PfamiView protein in Pfam
PF01351 RNase_HII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00729 TIGR00729, 1 hit

Sequencei

Sequence statusi: Complete.

U3CWF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSELERDN TGRCRLSSPV PAVCGKEPCV VGVDEAGRGP VLGPMVYAIC
60 70 80 90 100
YCPLSRLADL EALKVADSKT LSESERERLL GKMQEDGNFV GWALDVLSPN
110 120 130 140 150
LISTSMLGRV KYNLNSLSHD TATGLIQYAL DQGVNVTQVF VDTVGMPETY
160 170 180 190 200
QKRLQQSFPG IEVTVKAKAD ALYPVVSAAS ICAKVARDQA VKNWQFVEKL
210 220 230 240 250
QDLDTDYGSG YPNDPKTKVW LKEHVEPVFG FPQFVRFSWR TAQTILEKEA
260 270 280 290 300
KDVIWEDSAP EDQEGLGKIT SYFFNEGSRV CPRASHRYFL ERGLESATSL
Length:300
Mass (Da):33,284
Last modified:November 13, 2013 - v1
Checksum:i83E619EBFE8FA496
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GAMS01007404 mRNA Translation: JAB15732.1
GAMR01010025 mRNA Translation: JAB23907.1
GAMQ01004840 mRNA Translation: JAB37011.1

Similar proteinsi

Entry informationi

Entry nameiU3CWF1_CALJA
AccessioniPrimary (citable) accession number: U3CWF1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: April 25, 2018
This is version 10 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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