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Protein

Thymidine kinase

Gene

tdk

Organism
Leptotrichia sp. oral taxon 215 str. W9775
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96Proton acceptorUniRule annotation1
Metal bindingi152ZincUniRule annotation1
Metal bindingi155ZincUniRule annotation1
Metal bindingi190ZincUniRule annotation1
Metal bindingi193ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27ATPUniRule annotation8
Nucleotide bindingi95 – 98ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
ORF Names:HMPREF1984_02013Imported
OrganismiLeptotrichia sp. oral taxon 215 str. W9775Imported
Taxonomic identifieri1321779 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesLeptotrichiaceaeLeptotrichia
Proteomesi
  • UP000016640 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

U2SU76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFQINKNIV SMGSLEVITG SMFSGKSEEL IRRLRRAKYA KQKIVVFSPS
60 70 80 90 100
IDNRYGEKGI YSHGKESLEA YSVNSVNQME EIMTENIDAQ VIGIDEVQFL
110 120 130 140 150
GEDVVRFCKK YVEYGKRIIV AGLDLSFRAE PYHPVPELMS ISDRVDKLNA
160 170 180 190 200
ICTVCGKPAY ASQRLINGEP AYYDDPLVMV GASENYEARC RRHHIVKHKE
210 220 230 240 250
EEKGKILFVI GTEIDAGKKE VEENYREKFL KGKKCETLII KSRINEFEEN
260 270 280 290 300
ASEVSKNDFS LVDLRNKVGK AISENDCVFI RIIGGLLLPL EGYYSILDFI
310 320 330 340 350
CEYRKKSEIV IVAKNKKGLL NQVLLTVDLL KKSDLNIGKI IYKNGNDEKE
360 370
HEEVLEEIKD ITHLEYEFVN
Length:370
Mass (Da):42,300
Last modified:November 13, 2013 - v1
Checksum:i7A3458E50A9D7C2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AWVR01000075 Genomic DNA Translation: ERK66072.1

Genome annotation databases

EnsemblBacteriaiERK66072; ERK66072; HMPREF1984_02013
PATRICifig|1321779.3.peg.1905

Similar proteinsi

Entry informationi

Entry nameiU2SU76_9FUSO
AccessioniPrimary (citable) accession number: U2SU76
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: March 28, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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