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Protein

Thiamine thiazole synthase

Gene

thi4

Organism
Haloquadratum walsbyi J07HQW1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42NADUniRule annotation1
Binding sitei69NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi167Iron; shared with adjacent protomerUniRule annotation1
Binding sitei167NAD; shared with adjacent protomerUniRule annotation1
Metal bindingi182IronUniRule annotation1
Binding sitei257NAD; via amide nitrogenUniRule annotation1
Binding sitei267GlycineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi61 – 62NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processThiamine biosynthesisUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation, NADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00060

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine thiazole synthaseUniRule annotation (EC:4.-.-.-UniRule annotation)
Gene namesi
Name:thi4UniRule annotation
ORF Names:J07HQW1_00496Imported
OrganismiHaloquadratum walsbyi J07HQW1Imported
Taxonomic identifieri1238424 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloquadratum
Proteomesi
  • UP000030649 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the THI4 family.UniRule annotation

Phylogenomic databases

OrthoDBiPOG093Z09PU

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00304 Thi4, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002922 Thi4_fam
IPR022828 Thi4_prok
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR00292 TIGR00292, 1 hit

Sequencei

Sequence statusi: Complete.

U1MLF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFDEFADVS EAQVTRAIAK EWGNEFIERV DTEVIIVGGG PSGLVTAKEL
60 70 80 90 100
AERGVDVTIV EKNNYLGGGF WLGGFLMNKV TVRDPAQSVL DELGVPYEES
110 120 130 140 150
DEASGLYVAD GPHAVSSLIK SACDAGAEVQ NMTEFTDVVT RENNRVGGIV
160 170 180 190 200
LNWTPVHALP RELTCVDPVA VESDLVVDST GHDAVVISKL SERGVLNAPG
210 220 230 240 250
IEHANENNTG MDNTAEDEYG APGHDSPGHD SMWVSRSEDQ VVDHTGVVHP
260 270 280 290 300
GVVATGMAVA TVEGLPRMGP TFGAMLLSGK RGAQACLNEL GREATPIDFT

SAAPADD
Length:307
Mass (Da):32,401
Last modified:November 13, 2013 - v1
Checksum:i401B5D9CE6E27CE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KE356560 Genomic DNA Translation: ERG90474.1

Similar proteinsi

Entry informationi

Entry nameiU1MLF1_9EURY
AccessioniPrimary (citable) accession number: U1MLF1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: April 25, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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