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Protein

Probable crotonobetaine/carnitine-CoA ligase

Gene

caiC

Organism
Escherichia coli HVH 70 (4-2963531)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle.UniRule annotation

Pathwayi: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported

Enzyme and pathway databases

UniPathwayiUPA00117.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable crotonobetaine/carnitine-CoA ligaseUniRule annotation (EC:6.2.1.-UniRule annotation)
Gene namesi
Name:caiCUniRule annotation
ORF Names:G736_00035Imported
OrganismiEscherichia coli HVH 70 (4-2963531)Imported
Taxonomic identifieri1281011 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000016096 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliT6IHB9.
SMRiT6IHB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 426AMP-bindingInterPro annotationAdd BLAST410
Domaini435 – 510AMP-binding_CInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Family and domain databases

HAMAPiMF_01524. CaiC. 1 hit.
InterProiView protein in InterPro
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023456. CaiC.
PfamiView protein in Pfam
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PROSITEiView protein in PROSITE
PS00455. AMP_BINDING. 1 hit.

Sequencei

Sequence statusi: Complete.

T6IHB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIIGGQHLR QMWDDLADVY GHKTALICES SSGVVNRYSY LELNQEINRT
60 70 80 90 100
ANLFYTLGIR KGDKVALHLD NCPEFIFCWF GLAKIGAIMV PINARLLREE
110 120 130 140 150
STWILQNSQA CLLVTSAQFY PMYQQIQQED ASQLRHICLT DMVLPADDGV
160 170 180 190 200
SSFTQLKNQQ PATLCYAPPL STDDTAEILF TSGTTSRPKG VVITHYNLRF
210 220 230 240 250
AGYYSAWQCA LRDDDVYLTV MPAFHIDCQC TAAMAAFSAG ATFVLVEKYS
260 270 280 290 300
ARAFWGQVQK YRATITECIP MMIRTLMVQP LSANDQQHRL REVMFYLNLS
310 320 330 340 350
EQEKDAFCER FSVRLLTSYG MTETIVGIIG DRPGDKRRWP SIGRAGFCYE
360 370 380 390 400
AEIRDDHNRP LPAGELGEIC IKGVPGKTIF KEYFLNPKAT AKVLEADGWL
410 420 430 440 450
HTGDTGYRDE EGFFYFVDRR CNMIKRGGEN VSCVELENII ATHPKIQDIV
460 470 480 490 500
VVGIKDSIRD EAIKAFVVLN EGETLSEEEF FCFCEQNMAK FKVPSYLEIR
510
KDLPRNCSGK IIRKNLK
Length:517
Mass (Da):58,655
Last modified:November 13, 2013 - v1
Checksum:iC66E32D6A3BD27F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AVUW01000001 Genomic DNA. Translation: EQP60455.1.
RefSeqiWP_001298634.1. NZ_KE699408.1.

Genome annotation databases

EnsemblBacteriaiEQP60455; EQP60455; G736_00035.
PATRICifig|1281011.3.peg.36.

Similar proteinsi

Entry informationi

Entry nameiT6IHB9_ECOLX
AccessioniPrimary (citable) accession number: T6IHB9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: June 7, 2017
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported