caiC

Functionⁱ

Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle.UniRule annotation

Pathwayⁱ: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

GO - Molecular functionⁱ

acid-thiol ligase activity Source: InterPro
carnitine-CoA ligase activity Source: InterPro
crotonobetaine-CoA ligase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carnitine metabolic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	LigaseUniRule annotationImported

Molecular function

LigaseUniRule annotationImported

Enzyme and pathway databases

UniPathwayⁱ	UPA00117.

UniPathwayⁱ

UPA00117.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable crotonobetaine/carnitine-CoA ligaseUniRule annotation (EC:6.2.1.-UniRule annotation)
Gene namesⁱ	Name:caiCUniRule annotation ORF Names:G736_00035Imported
Organismⁱ	Escherichia coli HVH 70 (4-2963531)Imported
Taxonomic identifierⁱ	1281011 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000016096 Componentⁱ: Unassembled WGS sequence

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	T6IHB9.
SMRⁱ	T6IHB9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	17 – 426	AMP-bindingInterPro annotationAdd BLAST		410
Domainⁱ	435 – 510	AMP-binding_CInterPro annotationAdd BLAST		76

Sequence similaritiesⁱ

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Family and domain databases

HAMAPⁱ	MF_01524. CaiC. 1 hit.
InterProⁱ	View protein in InterPro IPR025110. AMP-bd_C. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. IPR023456. CaiC.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00501. AMP-binding. 1 hit. PF13193. AMP-binding_C. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00455. AMP_BINDING. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

T6IHB9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDIIGGQHLR QMWDDLADVY GHKTALICES SSGVVNRYSY LELNQEINRT 
        60         70         80         90        100
ANLFYTLGIR KGDKVALHLD NCPEFIFCWF GLAKIGAIMV PINARLLREE 
       110        120        130        140        150
STWILQNSQA CLLVTSAQFY PMYQQIQQED ASQLRHICLT DMVLPADDGV 
       160        170        180        190        200
SSFTQLKNQQ PATLCYAPPL STDDTAEILF TSGTTSRPKG VVITHYNLRF 
       210        220        230        240        250
AGYYSAWQCA LRDDDVYLTV MPAFHIDCQC TAAMAAFSAG ATFVLVEKYS 
       260        270        280        290        300
ARAFWGQVQK YRATITECIP MMIRTLMVQP LSANDQQHRL REVMFYLNLS 
       310        320        330        340        350
EQEKDAFCER FSVRLLTSYG MTETIVGIIG DRPGDKRRWP SIGRAGFCYE 
       360        370        380        390        400
AEIRDDHNRP LPAGELGEIC IKGVPGKTIF KEYFLNPKAT AKVLEADGWL 
       410        420        430        440        450
HTGDTGYRDE EGFFYFVDRR CNMIKRGGEN VSCVELENII ATHPKIQDIV 
       460        470        480        490        500
VVGIKDSIRD EAIKAFVVLN EGETLSEEEF FCFCEQNMAK FKVPSYLEIR 
       510 
KDLPRNCSGK IIRKNLK

Length:517

Mass (Da):58,655

Last modified:November 13, 2013 - v1

Checksum:ⁱC66E32D6A3BD27F6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AVUW01000001 Genomic DNA. Translation: EQP60455.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_001298634.1. NZ_KE699408.1.

Genome annotation databases

EnsemblBacteriaⁱ	EQP60455; EQP60455; G736_00035.
PATRICⁱ	fig\|1281011.3.peg.36.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
T6IHB9	Q0TLV2 Q8FLA5 A0A192ELI7 S1NX22 A0A0H3ECQ9 UPI0005A9D98E	Escherichia coli O6:K15:H31 (strain 536 / UPEC) Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) Escherichia coli Escherichia coli KTE182 Escherichia coli O83:H1 (strain NRG 857C / AIEC)	517	UniRef100_Q0TLV2	Cluster: Crotonobetaine/carnitine--CoA ligase	7

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
T6IHB9	Q8XA34 B5YYD1 A0A2J9N146 A0A152UP26 A0A0H3PW02 A0A0F6F0L6 C3TRB8 A0A0F6BYN3 UPI0007A60997 A0A1Q6AE35 +744	Escherichia coli O157:H7 Escherichia coli O157:H7 (strain EC4115 / EHEC) Escherichia coli O157 Escherichia coli Escherichia coli O157:H7 (strain EC869) Escherichia coli O157:H7 str. SS52 Escherichia coli Xuzhou21 uncultured bacterium Escherichia coli UMEA 3718-1 Escherichia coli O174:H8 str. 04-3038 And more	517	UniRef90_Q8XA34	Cluster: Crotonobetaine/carnitine--CoA ligase	755

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
T6IHB9	Q8XA34 B5YYD1 A0A2J9N146 A0A152UP26 A0A0H3PW02 A0A0F6F0L6 C3TRB8 A0A0F6BYN3 UPI0007A60997 V0Y2I0 +913	Escherichia coli O157:H7 Escherichia coli O157:H7 (strain EC4115 / EHEC) Escherichia coli O157 Escherichia coli Escherichia coli O157:H7 (strain EC869) Escherichia coli O157:H7 str. SS52 Escherichia coli Xuzhou21 Escherichia coli 908525 Escherichia coli H605 Escherichia coli TW10509 And more	517	UniRef50_Q8XA34	Cluster: Crotonobetaine/carnitine--CoA ligase	924

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AVUW01000001 Genomic DNA. Translation: EQP60455.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_001298634.1. NZ_KE699408.1.

3D structure databases

ProteinModelPortalⁱ	T6IHB9.
SMRⁱ	T6IHB9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	EQP60455; EQP60455; G736_00035.
PATRICⁱ	fig\|1281011.3.peg.36.

Enzyme and pathway databases

UniPathwayⁱ	UPA00117.

UniPathwayⁱ

UPA00117.

Family and domain databases

HAMAPⁱ	MF_01524. CaiC. 1 hit.
InterProⁱ	View protein in InterPro IPR025110. AMP-bd_C. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. IPR023456. CaiC.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00501. AMP-binding. 1 hit. PF13193. AMP-binding_C. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00455. AMP_BINDING. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	T6IHB9_ECOLX
Accessionⁱ	T6IHB9Primary (citable) accession number: T6IHB9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 13, 2013
	Last sequence update:	November 13, 2013
	Last modified:	June 7, 2017
	This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termⁱ

Complete proteomeImported

UniProtKB - T6IHB9 (T6IHB9_ECOLX)

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Probable crotonobetaine/carnitine-CoA ligase

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Functionⁱ

Pathwayⁱ: carnitine metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Caution

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - T6IHB9 (T6IHB9_ECOLX)

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Probable crotonobetaine/carnitine-CoA ligase

caiC

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: carnitine metabolism

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

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Functionⁱ

Pathwayⁱ: carnitine metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ