Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proteasome subunit alpha

Gene

prcA

Organism
Mycobacterium avium subsp. hominissuis (strain TH135)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotationSAAS annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotationSAAS annotation

Enzyme regulationi

The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Pathwayi: proteasomal Pup-dependent pathway

This protein is involved in the pathway proteasomal Pup-dependent pathway, which is part of Protein degradation.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway proteasomal Pup-dependent pathway and in Protein degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00997.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome alpha subunitUniRule annotation
Proteasome core protein PrcAUniRule annotation
Gene namesi
Name:prcAUniRule annotationImported
ORF Names:MAH_2719Imported
OrganismiMycobacterium avium subsp. hominissuis (strain TH135)Imported
Taxonomic identifieri1229671 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
Proteomesi
  • UP000016440 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation, ProteasomeUniRule annotationSAAS annotation

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliT2GTA0.
SMRiT2GTA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00289_B. Proteasome_A_B. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR022296. Proteasome_asu_bac.
IPR001353. Proteasome_sua/b.
PANTHERiPTHR11599:SF69. PTHR11599:SF69. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03691. 20S_bact_alpha. 1 hit.
PROSITEiView protein in PROSITE
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

T2GTA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPYFISPE QAMRERSELA RKGIARGKSV VALVYAGGVL FVAENPSRSL
60 70 80 90 100
QKISELYDRV GFAAAGKFNE FDNLRRGGIQ FADTRGYAYD RRDVTGRQLA
110 120 130 140 150
NVYAQTLGTI FTEQAKPYEV ELCVAEVAHY GETKPPELYR ITYDGSIADE
160 170 180 190 200
PHFVVMGGTT EPITTALKDS YAENANLREA TRIAVRALRA GSESSNGDQS
210 220 230 240 250
ALDVGSLEVA ILDVNRPRRA FRRINRPTLE NLLRELDSNG SDGNGDAPEL

NGGSSD
Length:256
Mass (Da):28,078
Last modified:November 13, 2013 - v1
Checksum:i74B8A6ADF419D355
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012555 Genomic DNA. Translation: BAN31793.1.
RefSeqiWP_003878079.1. NZ_AP012555.1.

Genome annotation databases

EnsemblBacteriaiBAN31793; BAN31793; MAH_2719.
GeneIDi2720295.

Similar proteinsi

Entry informationi

Entry nameiT2GTA0_MYCHT
AccessioniPrimary (citable) accession number: T2GTA0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: March 28, 2018
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported