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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotationImported
ORF Names:ERS021858_01881Imported
OrganismiStreptococcus pneumoniaeImported
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000042664 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Transmembranei47 – 69HelicalUniRule annotationAdd BLAST23
Transmembranei75 – 95HelicalUniRule annotationAdd BLAST21
Transmembranei115 – 132HelicalUniRule annotationAdd BLAST18
Transmembranei138 – 160HelicalUniRule annotationAdd BLAST23
Transmembranei172 – 191HelicalUniRule annotationAdd BLAST20
Transmembranei197 – 214HelicalUniRule annotationAdd BLAST18
Transmembranei221 – 242HelicalUniRule annotationAdd BLAST22
Transmembranei248 – 269HelicalUniRule annotationAdd BLAST22
Transmembranei306 – 325HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

T2BRM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFISISAGIV TFLLTLVGIP AFIQFYRKAQ ITGQQMHEDV KQHQAKAGTP
60 70 80 90 100
TMGGLVFLIT SVLVAFFFAL FSSQFSNNVG MILFILVLYG LVGFLDDFLK
110 120 130 140 150
VFRKINEGLN PKQKLALQLL GGVIFYLFYE RGGDILSVFG YPVHLGFFYI
160 170 180 190 200
FFALFWLVGF SNAVNLTDGV DGLASISVVI SLFAYGVIAY VQGQMDILLV
210 220 230 240 250
ILAMIGGLLG FFIFNHKPAK VFMGDVGSLA LGGMLAAISM ALHQEWTLLI
260 270 280 290 300
IGIVYVFETT SVMMQVSYFK LTGGKRIFRM TPVHHHFELG GLSGKGNPWS
310 320
EWKVDFFFWG VGLLASLLTL AILYLM
Length:326
Mass (Da):36,063
Last modified:November 13, 2013 - v1
Checksum:i2B9E4F9393589401
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC522456 Genomic DNA Translation: AGV15779.1
CLYF01000045 Genomic DNA Translation: CJU06099.1
RefSeqiWP_000470833.1, NZ_MLHF01000053.1

Genome annotation databases

EnsemblBacteriaiCJU06099; CJU06099; ERS021858_01881
CVM31554; CVM31554; ERS367628_00076

Similar proteinsi

Entry informationi

Entry nameiT2BRM5_STREE
AccessioniPrimary (citable) accession number: T2BRM5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: March 28, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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