ID   T1ZC06_STRIT            Unreviewed;       920 AA.
AC   T1ZC06;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   Name=nanA {ECO:0000313|EMBL:AGU75433.1};
GN   ORFNames=SIR_0015 {ECO:0000313|EMBL:AGU75433.1};
OS   Streptococcus intermedius B196.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus; Streptococcus anginosus group.
OX   NCBI_TaxID=862967 {ECO:0000313|EMBL:AGU75433.1, ECO:0000313|Proteomes:UP000016233};
RN   [1] {ECO:0000313|EMBL:AGU75433.1, ECO:0000313|Proteomes:UP000016233}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B196 {ECO:0000313|EMBL:AGU75433.1,
RC   ECO:0000313|Proteomes:UP000016233};
RX   PubMed=24341328; DOI=10.1186/1471-2164-14-895;
RA   Olson A.B., Kent H., Sibley C.D., Grinwis M.E., Mabon P., Ouellette C.,
RA   Tyson S., Graham M., Tyler S.D., Van Domselaar G., Surette M.G.,
RA   Corbett C.R.;
RT   "Phylogenetic relationship and virulence inference of Streptococcus
RT   Anginosus Group: curated annotation and whole-genome comparative analysis
RT   support distinct species designation.";
RL   BMC Genomics 14:895-895(2013).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; CP003857; AGU75433.1; -; Genomic_DNA.
DR   RefSeq; WP_021002265.1; NZ_UZBH01000005.1.
DR   AlphaFoldDB; T1ZC06; -.
DR   KEGG; sib:SIR_0015; -.
DR   PATRIC; fig|862967.3.peg.15; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_002070_0_0_9; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000016233; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR004124; Glyco_hydro_33_N.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR023364; Trans_sialidase_dom3.
DR   NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF02973; Sialidase; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000313|EMBL:AGU75433.1};
KW   Hydrolase {ECO:0000313|EMBL:AGU75433.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016233};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        897..915
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          81..271
FT                   /note="Glycoside hydrolase family 33 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02973"
FT   DOMAIN          501..724
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   REGION          849..878
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        858..878
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   920 AA;  103075 MW;  E0A5A9AF72788B0E CRC64;
     MNWSFFNWKK QDKIRKLVVG ATFIVIGIAI FLALSGLKQV NTVLANTKKV ESGINNSIAD
     LLKETNVIPR DYYARQLENV QTIFEKENVV TNDSNNQRID LSGELDKLKQ LQTATIHIEF
     KADANAPRFY NLFSVSSDKV KNEYFTMAVY NNTAIVEGRD KDGKQFYNSY NDAPLKIKSG
     QWNSVTFTVD GPNSDHPNGQ VRLYVNGVLS RTSKLSGRFI KDMPDVNHVQ IGKTNRARSM
     MWGSNLHVRN LTVYNRALTS EEVQKRSQLF KRSDLEKRLP EGALLTEKTD VFKSGYNNQP
     NSEGINSYRI PALLRTDKGT LIAGADQRRL HHADYGDIGM VVRRSEDNGK TWGDKKVLSN
     LRDNPDAKDP VAPSPLNIDM TLVQDPTTKR IFAIYDMFPE GKGIFGMPKN NEKAYEQVGD
     KTYQILYKQG EFGHYTIREN GEVYDANNQK TDYRVVVNPT KADYRDKGDI YKGQELVGNI
     YFAQSKKNPF RIAYTSYLWM SYSDDDGKTW SAPRDITSGV RKDWMKFLGT GPGTGIVLRT
     GKHKGRILIP VYTTNNVSHL NGSQSSRLIY SDDHGETWHA GEAVNDNRQV GGQKIHSSTM
     NNRNAQNTES TVVQLNNGDI KLFMRGLTGD LQVATSKDGG ATWEKEIKRY PQVKDVYVQM
     SAIHTMHDGI EYVVLSNAGG PERTNGLVHL ARVEKNGELT WLKHNLIQKG EFAYNSLQDL
     GNGEYGLFYE HRENGQNPYT LSYKKFNWDF LSKDLISPKE VKVKKAVDRG KGVVGLEFDS
     EVLVNQAPTL ELTNGKIATF ITQYDSKTLL FKVDKGAIGQ KITGLASGSI ESIHNLPVNL
     TGASIPGGVN GGEGTVNEVP EYKEKKSTKK PATEKKQANK VLTNHHNLPS TGSTTNVPVL
     FLGIATIILG LLTMINKRKQ
//