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Protein

Pantothenate synthetase

Gene

panC

Organism
Staphylococcus aureus subsp. aureus CN1
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotationSAAS annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43Proton donorUniRule annotation1
Binding sitei67Beta-alanineUniRule annotation1
Binding sitei67PantoateUniRule annotation1
Binding sitei159PantoateUniRule annotation1
Binding sitei182ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 43ATPUniRule annotation8
Nucleotide bindingi153 – 156ATPUniRule annotation4
Nucleotide bindingi190 – 193ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processPantothenate biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
ORF Names:SAKOR_02591Imported
OrganismiStaphylococcus aureus subsp. aureus CN1Imported
Taxonomic identifieri1193576 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000016220 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01918.

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC. 1 hit.
InterProiView protein in InterPro
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiView protein in Pfam
PF02569. Pantoate_ligase. 1 hit.
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

T1YBT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLITMTKLI TTVKEMQHIV KAAKRSGTTI GFIPTMGALH DGHLTMVRES
60 70 80 90 100
VSTNDITVVS VFVNPLQFGP NEDFDAYPRQ IDKDLELVSE VGADIVFHPA
110 120 130 140 150
VEDMYPGELG IDVKVGPLAD VLEGAKRPGH FDGVVTVVNK LFNIVMPDYA
160 170 180 190 200
YFGKKDAQQL AIVEQMVKDF NHAVEIIGID IVREADGLAK SSRNVYLTEK
210 220 230 240 250
ERQEAVHLSK SLLLAQALYQ DGERQSKVII DRVTEYLESH ISGRIEEVAV
260 270 280
YSYPQLVEQH EITGRIFISL AVKFSKARLI DNIIIGAE
Length:288
Mass (Da):32,063
Last modified:November 13, 2013 - v1
Checksum:i1F6674A9FD5017C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003979 Genomic DNA. Translation: AGU62731.1.

Genome annotation databases

EnsemblBacteriaiAGU62731; AGU62731; SAKOR_02591.
KEGGisaun:SAKOR_02591.
PATRICifig|1193576.3.peg.2444.

Similar proteinsi

Entry informationi

Entry nameiT1YBT9_STAAU
AccessioniPrimary (citable) accession number: T1YBT9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: October 25, 2017
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported