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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene
N/A
Organism
Strigamia maritima (European centipede) (Geophilus maritimus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

Protein has several cofactor binding sites:

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Ligand2Fe-2SUniRule annotation, 3Fe-4SUniRule annotation, 4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
OrganismiStrigamia maritima (European centipede) (Geophilus maritimus)Imported
Taxonomic identifieri126957 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaMyriapodaChilopodaPleurostigmophoraGeophilomorphaLinotaeniidaeStrigamia
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 1962Fe-2S ferredoxin-typeInterPro annotationAdd BLAST94
Domaini239 – 2694Fe-4S ferredoxin-typeInterPro annotationAdd BLAST31

Sequence similaritiesi

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.UniRule annotation

Phylogenomic databases

OMAiESWIHTN
PhylomeDBiT1JMB6

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

T1JMB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NVKSKRKKNL FNFWFELDLL LDTSSRPRAP RKCSFSSLVD AVQIEMAAYV
60 70 80 90 100
PFVKLGWSFG LMSINHGTII IPIRAAAAAA ASAPVAAPAS VPAPPKSSSP
110 120 130 140 150
RIKQFSIYRW NPEKKNQKPH MQTYDVDLNA CGPMVLDALI KIKNEMDPTL
160 170 180 190 200
TFRRSCREGI CGSCSMNIGG VNTLACISKI DTSLSRSTKI YPLPHMYVVK
210 220 230 240 250
DLVPDMSNFY EQYRSIEPYL KRKSNVPLGS QQYLQSETDR KKLDGLYECI
260 270 280 290 300
LCACCSTSCP SYWWNSDKYL GPAVLLQAYR WIIDSRDDFS QERLERLKDP
310 320 330 340
FSVYRCHTIM NCTKTCPKSL NPGKAIAEIK KLLSGIAKKD APELAPK
Length:347
Mass (Da):39,012
Last modified:October 16, 2013 - v1
Checksum:iD57A54398BEF1575
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH431430 Genomic DNA No translation available.

Genome annotation databases

EnsemblMetazoaiSMAR014996-RA; SMAR014996-PA; SMAR014996

Entry informationi

Entry nameiT1JMB6_STRMM
AccessioniPrimary (citable) accession number: T1JMB6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: December 20, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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