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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacillus sp. WSUCF1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei616ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:I656_04005Imported
OrganismiGeobacillus sp. WSUCF1Imported
Taxonomic identifieri886559 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000014961 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 207tRNA-synt_1gInterPro annotationAdd BLAST133
Domaini256 – 436tRNA-synt_1_2InterPro annotationAdd BLAST181
Domaini449 – 641tRNA-synt_1InterPro annotationAdd BLAST193
Domaini695 – 805Anticodon_1InterPro annotationAdd BLAST111

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili804 – 824Sequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi613 – 617"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 2 hits.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

S7TX92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPREARLSS LCCGDGGVFL YIFSSMMQVE LDRRSAAMSF NHREIEQKWQ
60 70 80 90 100
DYWEKNKTFR TSDDDDKPKF YVLDMFPYPS GAGLHVGHPE GYTATDILAR
110 120 130 140 150
MKRMQGYNVL HPMGWDAFGL PAEQYALDTG NDPAEFTQKN IDNFRRQIKS
160 170 180 190 200
LGFSYDWDRE INTTDPNYYK WTQWIFLKLY EKGLAYMDEV PVNWCPALGT
210 220 230 240 250
VLANEEVING RSERGGHPVI RKPMRQWMLK ITAYADRLLE DLEELDWPES
260 270 280 290 300
IKEMQRNWIG RSEGAEIEFA VDGHDETFTV FTTRPDTLFG ATYTVLAPEH
310 320 330 340 350
PLVEKITTPE QKPAVDAYLK EIQSKSDLER TDLAKEKTGV FTGAYAIHPV
360 370 380 390 400
TGDRLPIWIA DYVLMSYGTG AIMAVPAHDE RDYEFAKTFH LPIKEVVAGG
410 420 430 440 450
NIEKEAYTGD GEHINSEFLN GLNKQEAIDK MIAWLEEHGK GRKKVSYRLR
460 470 480 490 500
DWLFSRQRYW GEPIPIIHWE DGTMTPVPEE ELPLVLPKTD EIKPSGTGES
510 520 530 540 550
PLANIEEWVN VVDPKTGKKG RRETNTMPQW AGSCWYYLRY IDPHNDKQLA
560 570 580 590 600
DPEKLKKWLP VDVYIGGAEH AVLHLLYARF WHKFLYDLGI VPTKEPFQKL
610 620 630 640 650
FNQGMILGEN NEKMSKSKGN VVNPDDIIES HGADTLRLYE MFMGPLEASI
660 670 680 690 700
AWSTKGLDGA RRFLDRVWRL FVTENGELNP NIVDEPANDT LERIYHQTVK
710 720 730 740 750
KVTEDYESLR FNTAISQLMV FINEAYKAEQ MKKEYMEGFV KLLSPVCPHI
760 770 780 790 800
GEELWQKLGH TDTIAYEPWP TYDETKLVED VVEIVVQING KVRSRLHVPV
810 820 830 840
DLPKEALEER ALADEKIKEQ LEGKTVRKVI AVPGKLVNIV AN
Length:842
Mass (Da):96,821
Last modified:October 16, 2013 - v1
Checksum:i443A976F4BC40628
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ATCO01000237 Genomic DNA. Translation: EPR26369.1.

Genome annotation databases

EnsemblBacteriaiEPR26369; EPR26369; I656_04005.
PATRICifig|886559.3.peg.3819.

Similar proteinsi

Entry informationi

Entry nameiS7TX92_9BACI
AccessioniPrimary (citable) accession number: S7TX92
Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: March 28, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported