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Protein

DNA topoisomerase 2

Gene

D623_10006170

Organism
Myotis brandtii (Brandt's bat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, Isomerase, TopoisomeraseUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 2UniRule annotation (EC:5.99.1.3UniRule annotation)
Gene namesi
ORF Names:D623_10006170Imported
OrganismiMyotis brandtii (Brandt's bat)Imported
Taxonomic identifieri109478 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaChiropteraMicrochiropteraVespertilionidaeMyotis
Proteomesi
  • UP000052978 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini500 – 617ToprimInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the type II topoisomerase family.UniRule annotation

Family and domain databases

CDDicd03365. TOPRIM_TopoIIA. 1 hit.
Gene3Di1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
3.40.50.670. 1 hit.
3.90.199.10. 1 hit.
InterProiView protein in InterPro
IPR024946. Arg_repress_C-like.
IPR012542. DTHCT.
IPR003594. HATPase_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013760. Topo_IIA-like_dom.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013506. Topo_IIA_bsu_dom2.
IPR013759. Topo_IIA_cen_dom.
IPR018522. TopoIIA_CS.
IPR031660. TOPRIM_C.
IPR006171. TOPRIM_domain.
IPR034157. TOPRIM_TopoII.
PANTHERiPTHR10169. PTHR10169. 1 hit.
PfamiView protein in Pfam
PF00204. DNA_gyraseB. 1 hit.
PF00521. DNA_topoisoIV. 1 hit.
PF08070. DTHCT. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
PF16898. TOPRIM_C. 1 hit.
PRINTSiPR00418. TPI2FAMILY.
SMARTiView protein in SMART
SM00433. TOP2c. 1 hit.
SM00434. TOP4c. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56719. SSF56719. 1 hit.
PROSITEiView protein in PROSITE
PS00177. TOPOISOMERASE_II. 1 hit.
PS50880. TOPRIM. 1 hit.

Sequencei

Sequence statusi: Complete.

S7NVH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRIPFGNGD GGGGLSKAII LAAASSAWGL GEPGVTRPAL PVPAIYNTLF
60 70 80 90 100
DQNNAAKKEE SETANRNDSS KKLSVERVYQ KKTQLEHILL RPDTYIGSVE
110 120 130 140 150
PLTQVMWVYD EDVGMNCREV TFVPGLYKIF DEILVNAADN KQRDKNMTCI
160 170 180 190 200
KVSIDPESNI ISIWNNGKGI PVVEHKVEKV YVPALIFGQL LTSSNYDDDE
210 220 230 240 250
KKVTGGRNGY GAKLCNIFST KFTVETACKE YKHSFKQTWM NNMMKTSEAK
260 270 280 290 300
IKHFDGEDYT CITFQPDLSK FKMEKLDKDI VALMTRRAYD LAGSCKGVKV
310 320 330 340 350
MFNGKKLPVN GFRSYVDLYV KDKLDETGVA LKVIHELANE RWDVCLTLSE
360 370 380 390 400
KGFQQISFVN SIATTKGGRH VDYVVDQVVG KLIEVVKKKN KAGVSVKPFQ
410 420 430 440 450
VKNHIWVFIN CLIENPTFDS QTKENMTLQP KSFGSKCQLS EKFFKAASNC
460 470 480 490 500
GIVESILNWV KFKAQTQLNK KCSSVKYSKI KGIPKLDDAN DAGGKHSLEC
510 520 530 540 550
TLILTEGDSA KSLAVSGLGV IGRDRYGVFP LRGKILNVRE ASHKQIMENA
560 570 580 590 600
EINNIIKIVG LQYKKSYDDA ESLKTLRYGK IMIMTDQDQD GSHIKGLLIN
610 620 630 640 650
FIHHNWPSLL KHGFLEEFIT PIVKASKNKQ ELSFYSIPEF DEWKKHIENQ
660 670 680 690 700
KAWKIKYYKG LGTSTAKEAK EYFADMERHR ILFRYAGPED DAAITLAFSK
710 720 730 740 750
KKIDDRKEWL TNFMEDRRQR RLHGLPEQFL YGTATKHLTY NDFINKELIL
760 770 780 790 800
FSNSDNERSI PSLVDGFKPG QRKVLFTCFK RNDKREVKVA QLAGSVAEMS
810 820 830 840 850
AYHHGEQALM MTIVNLAQNF VGSNNINLLQ PIGQFGTRLH GGKDAASPRY
860 870 880 890 900
IFTMLSSLAR RLFPIVDDNL LKFLYDDNQR VEPEWYIPII PMVLINGAEG
910 920 930 940 950
IGTGWACKLP NYDAREIVNN VRRMLDGLDP HPMLPNYKNF KGTIQELGQN
960 970 980 990 1000
QYAVSGEIFV VDRNTVEITE LPVRTWTQVY KEQVLEPMLN GTDKTPALIS
1010 1020 1030 1040 1050
DYKEYHTDTT VKFVVKMTEE KLAQAEAAGL HKVFKLQTTL TCNSMVLFDH
1060 1070 1080 1090 1100
MGCLKKYETV QDILKEFFDL RLSYYGLRKE WLVGMLGAES TKLNNQARFI
1110 1120 1130 1140 1150
LEKIQGKITI ENRSKKDLIQ MLVQRGYESD PVKAWKEAQE KATEEEETQN
1160 1170 1180 1190 1200
QHDDSSSDSG TPSGPDFNYI LNMSLWSLTK EKVEELIKQR DSKGREVNDL
1210 1220 1230 1240 1250
KRKSPSDLWK EDLAAFVEEL DKVEAQERED LMAGMAGKAV KGKVGKPKVK
1260 1270 1280 1290 1300
KLQLEETMPS PYGRRIVPEI TAMKADASKK LLKKKKGDLD TTAVKVECDE
1310 1320 1330 1340 1350
EFSGTPVEGT GEEALIQAVP INKGPKPKRE KKEPGTRVRK RKTSTSSGKP
1360 1370 1380 1390 1400
SAKKVKKRNP WSDDESKSES DLEETEPVVI PRDSLLRRAA AERPKYTFDF
1410 1420 1430 1440 1450
SEEEDDDADD DDDNNDLEEL KVKASPITND EEDEFVPSDG LDKDEYTFSP
1460 1470 1480 1490 1500
AKSKATPEKS SHDKKPQDFG NLFSFPSYSQ KLEDDSAKFD SNEEDSASVF
1510 1520 1530 1540 1550
SPTFGLKQID KVPSKTAAAK KGKPSSDTMP KPKRTPKQKK VETMNSDSDS
1560 1570 1580 1590 1600
EFGIPKKTTT PKGKGRGARK RKASGSENEG DYNPGRKTTR PPSKKLKKTS
1610 1620 1630 1640
FDQDSDVDIF PSDFASEPPS LPRTGRARKE VKYFAESDEE DDVDFAMFN
Length:1,649
Mass (Da):186,241
Last modified:October 16, 2013 - v1
Checksum:iC8CE7D6ED119DAD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KE161086 Genomic DNA. Translation: EPQ01653.1.

Similar proteinsi

Entry informationi

Entry nameiS7NVH2_MYOBR
AccessioniPrimary (citable) accession number: S7NVH2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 16, 2013
Last sequence update: October 16, 2013
Last modified: July 5, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported